TWIST基因和蛋白与宫颈癌发生发展关系的研究

目的:检测TWIST基因在宫颈癌组织和宫颈正常组织中的表达,探讨其与宫颈癌发生?发展的相关性及在宫颈癌诊疗中的意义?方法:收集56例宫颈癌组织和35例宫颈正常组织,用实时定量PCR检测TWIST mRNA的表达;用Western blot检测TWIST蛋白的表达,并分析TWIST mRNA在宫颈癌中的表达水平与临床病理因素及高危型HPV病毒载量相关性?结果:实时定量PCR结果显示宫颈癌组织中TWIST mRNA表达高于宫颈正常组织,差异具有统计学意义(P < 0.01);Western blot在蛋白质水平上证实了这一点(P < 0.01)?宫颈癌组织中TWIST的表达与淋巴结转移相关(P = 0.022),但与年龄?FIGO分期?肿瘤大小?病理类型?肿瘤分化程度无关(P均> 0.05),Logistic回归分析显示,高水平的TWIST mRNA表达是淋巴结转移的独立危险因子(P < 0.05)?而TWIST基因的相对表达水平与高危型HPV病毒载量无相关性(r = 0.205,P > 0.05)?结论:宫颈癌组织中TWIST的表达上调,且与是否有淋巴结转移相关,TWIST的表达可能对宫颈癌的发生?发展及转移有重要作用?     

Being black and non-citizen in South Africa: Intersecting race,white privilege and afrophobic violence in contemporary South Africa

Post-apartheid South Africa is characterized by growing feelings of pain, anger and frustration amongst black communities triggered by pervasive social inequalities. This has given birth to a new form of political and social activism shaped by crude violence, vandalism, destruction, brutal killings of women and children as well as thuggery in different black communities. It has also led to an upsurge in violence particularly on Africans from other parts of the continent. In this article, I attempt to examine how racial politics and resilient white privilege intersect to trigger afrophobic violence in South Africa. I draw on existing literature on broad conceptions of race and xenophobia to make a set of assertions about racial valuations, the resilience of white supremacy and black on black violence. In the article, I argue that black South Africans' pain, anger and the performance of violence on African migrants are on one level a consequence of resilient structural racism and racial practices, which continue to marginalize, emasculate and dispossess blacks. These racial practices force black South Africans to look elsewhere to express their anger, pains and frustrations.     

《黄金时代》传播、接受史研究

<黄金时代>自刊出后就受到评论界和学术界的广泛关注,对它的研究经历了不同的阶段.文中通过对<黄金时代>出版发行、传播、接受过程的梳理,进而研究其传播中受阻的现象,从而发现小说中关于"性"描写和知青小说书写两方面的开创性和超越性意义,并分析与此主题相关的研究热点,最后通过近十年的研究现状的梳理,对研究的走向作出预测.     

现代智库事业的发展历程及特征研究——基于学术研究视角

学术研究是解决科学问题和社会难题、促进科学与社会均衡发展的重要途径,学术研究活动的规模与其所对应的社会事业规模、发展阶段等均存在一定的对应关系.文章在揭示该对应关系的基础上,通过对WOSTM收录的“智库”主题的学术研究文献数量的趋势变化分析,将全球现代智库事业的发展历程划分为三个不同阶段,即形成初期、低速调整期、高速成长期,并通过词频分析和内容分析的方法对现代国际智库事业三个阶段的发展特征进行揭示,最后对中国现代智库事业的发展现状进行分析.通过对比分析得出,中国现代智库事业目前虽处于起步阶段,但正在沿着一条跨越式发展道路加速前进.