2m − p compromise plans with strongly clear specified main effects and two-factor interactions

This article studies two-level strongly clear compromise plans. We derive some necessary conditions for the existence of four classes of two-level strongly clear compromise plans which allow the estimations of some specified main effects and two-factor interactions, with the assumption that the fourth- or higher-order effects are negligible. Also, some methods for constructing 2^{m ? p} strongly clear compromise plans are introduced.     

Two-stage phase II trials with early stopping for effectiveness and safety as well as ineffectiveness or harm

This article proposes new optimal and minimax designs, which allow early stopping not only for ineffectiveness or toxicity but also for sufficient effectiveness and safety. These designs may facilitate effective drug development by detecting sufficient effectiveness and safety at an early stage or by detecting ineffectiveness or excessive toxicity at an early stage. The proposed design has advantage over other designs in the sense that it can control the type I error rate and is robust against the real association parameter. Comparing to Jin's design, it is always advantageous in terms of expected sample size.     

A case study in identifying targeted patients population in major depressive disorder by enhanced enrichment design

Despite advances in clinical trial design, failure rates near 80% in phase 2 and 50% in phase 3 have recently been reported. The challenges to successful drug development are particularly acute in central nervous system trials such as for pain, schizophrenia, mania, and depression because high‐placebo response rates lessen assay sensitivity, diminish estimated treatment effect sizes, and thereby decrease statistical power. This paper addresses the importance of rigorous patient selection in major depressive disorder trials through an enhanced enrichment paradigm. This approach led to a redefinition of an ongoing, blinded phase 3 trial algorithm for patient inclusion (1) to eliminate further randomization of transient placebo responders and (2) to exclude previously randomized transient responders from the primary analysis of the double blind phase of the trial. It is illustrated for a case study for the comparison between brexpiprazole + antidepressant therapy and placebo + antidepressant therapy. Analysis of the primary endpoint showed that efficacy of brexpiprazole versus placebo could not be established statistically if the original algorithm for identification of placebo responders was used, but the enhanced enrichment approach did statistically demonstrate efficacy. Additionally, the enhanced enrichment approach identified a target population with a clinically meaningful treatment effect. Through its successful identification of a target population, the innovative enhanced enrichment approach enabled the demonstration of a positive treatment effect in a very challenging area of depression research.     

团体心理辅导提升留守经历大学生心理资本研究——以西南石油大学为例

为了了解团体心理辅导对留守经历大学生心理资本水平的干预和提升效果,以心理资本问卷作为评估工具,采用实验组对照组前后测的实验设计,在西南石油大学公开招募留守经历大学生作为被试。研究发现：实验组前后测的心理资本得分有显著的差异,表现为实验组的心理资本及各维度的后测得分显著高于前测得分,对照组的心理资本前后测得分无显著差异;实验组与对照组的心理资本后测得分差异显著,表现为实验组的心理资本及各维度的后测得分显著高于前测得分;实验组中,绝大多数学生对整个团体活动感到满意,认为在活动中有所收获,觉得团体辅导对重新看待自己的过去和成长经历有较大帮助。     

小组工作对学龄初期儿童的介入初探——以湖北省荆州市实验小学××班为个案

学龄初期是指儿童从六七岁到十一、二岁这一时期,这时儿童进入学校,开始以学习为主导的活动。它是儿童心理发展的一个重要时期。作为社会工作专业方法之一的小组工作能帮助学龄初期儿童树立团结互助与分享意识,培养他们团结合作的精神,提高他们独立自主的能力。笔者从小组工作专业视角出发,以湖北省荆州市实验小学××班作为个案,描述并分析了学龄初期儿童的特征,阐述了小组工作方法对学龄初期儿童介入的可行性,探讨了小组工作方法的介入、评估及个人反思。     

心理弹性研究对危机干预工作的启示

危机干预和心理弹性的研究都是从危机情境出发,前者关注危机导致个体的不适应症状,后者关注危机中积极适应的个体。本文通过对心理弹性这一领域研究成果的梳理,并探讨传统危机干预的特点和模式,总结心理弹性研究对危机干预工作的启示：打破所有经历创伤情境的人都需要干预的假设,凸显评估的重要性;将负面情绪内化的个体更需要危机干预;重视情绪表达在危机干预中的作用;加强目标、计划在危机干预中的作用;在危机干预中提升当事人的心理弹性。     

允许直达的混合轴辐式快递网络规划模型与算法研究

在快递企业的日常运营中,当两个城市之间的快递业务量达到一定规模之后会允许该城市对之间开展直达递送。但是这一规则通常仅在快递网络规划完成之后由相关子公司提请实施。为弥补这一实际规则的局部最优性缺陷,本论文将直达问题纳入网络规划决策,基于全局优化的视角构建了允许直达的混合轴幅式快递网络规划决策模型,设计了相应的求解流程,并对其中的指派关系决策构建了遗传算法。基于国内标杆企业的数值案例计算证明了该决策模型与求解方法的有效性,研究结果还说明,相对于纯轴辐式结构,允许直达的混合轴幅式网络结构有助于降低网络总成本,同时在直达线路上能够有效的降低迂回、提高服务时效性和服务水平。     

中国制造业要素配置效率的测算、变化机制与政府干预效应

本文利用改进的APG模型框架对中国各省份地区制造业部门生产效率增长进行分解和测算,并针对导致中国制造业要素配置效率低下的动因进行深入分析。主要的发现是：技术效率和企业净进入是推动中国制造业生产效率增长的主要来源,而要素配置效率对中国制造业生产效率增长的贡献非常有限,由此验证要素市场的发展滞后是造成中国经济增长乏力的重要内在因素。进一步的检验发现是,地方政府对要素市场的干预是造成制造业要素配置效率低下的主要动因,这种干预效应总体上呈现倒U型关系。更为细致的分解结果表明,政府干预对于资本要素配置效率的作用效应呈倒U型关系,而对劳动要素配置效率呈U型关系。这些检验结果均证明,全面推进要素市场的市场化导向改革,减少政府干预对微观经济部门的扭曲性影响,是维持中国制造业生产效率可持续增长的重要改革措施。     

A Hybrid Geometric Phase II/III Clinical Trial Design based on Treatment Failure Time and Toxicity

The problem of comparing several experimental treatments to a standard arises frequently in medical research. Various multi-stage randomized phase II/III designs have been proposed that select one or more promising experimental treatments and compare them to the standard while controlling overall Type I and Type II error rates. This paper addresses phase II/III settings where the joint goals are to increase the average time to treatment failure and control the probability of toxicity while accounting for patient heterogeneity. We are motivated by the desire to construct a feasible design for a trial of four chemotherapy combinations for treating a family of rare pediatric brain tumors. We present a hybrid two-stage design based on two-dimensional treatment effect parameters. A targeted parameter set is constructed from elicited parameter pairs considered to be equally desirable. Bayesian regression models for failure time and the probability of toxicity as functions of treatment and prognostic covariates are used to define two-dimensional covariate-adjusted treatment effect parameter sets. Decisions at each stage of the trial are based on the ratio of posterior probabilities of the alternative and null covariate-adjusted parameter sets. Design parameters are chosen to minimize expected sample size subject to frequentist error constraints. The design is illustrated by application to the brain tumor trial.     

Efficient circular neighbour designs for spatial interference model

We consider circular block designs for field-trials when there are two-sided spatial interference between neighbouring plots of the same blocks. The parameter of interest is total effects that is the sum of direct effect of treatment and neighbour effects, which correspond to the use of a single treatment in the whole field. We determine universally optimal approximate designs. When the number of blocks may be large, we propose efficient exact designs generated by a single sequence of treatment. We also give efficiency factors of the usual binary block neighbour balanced designs which can be used when the number of blocks is small.