On the Principal Component Liu-type Estimator in Linear Regression

In this article, we present a principal component Liu-type estimator (LTE) by combining the principal component regression (PCR) and LTE to deal with the multicollinearity problem. The superiority of the new estimator over the PCR estimator, the ordinary least squares estimator (OLSE) and the LTE are studied under the mean squared error matrix. The selection of the tuning parameter in the proposed estimator is also discussed. Finally, a numerical example is given to explain our theoretical results.     

Adaptive and repeated cumulative meta‐analyses of safety data during a new drug development process

During a new drug development process, it is desirable to timely detect potential safety signals. For this purpose, repeated meta‐analyses may be performed sequentially on accumulating safety data. Moreover, if the amount of safety data from the originally planned program is not enough to ensure adequate power to test a specific hypothesis (e.g., the noninferiority hypothesis of an event of interest), the total sample size may be increased by adding new studies to the program. Without appropriate adjustment, it is well known that the type I error rate will be inflated because of repeated analyses and sample size adjustment. In this paper, we discuss potential issues associated with adaptive and repeated cumulative meta‐analyses of safety data conducted during a drug development process. We consider both frequentist and Bayesian approaches. A new drug development example is used to demonstrate the application of the methods. Copyright © 2015 John Wiley & Sons, Ltd.     

The Method to Identify a Biomarker and to Evaluate Its Efficiency for Survival by Using the Joint Model of the Accelerate Failure Time and Longitudinal Data

In this article, we discuss how to identify longitudinal biomarkers in survival analysis under the accelerated failure time model and also discuss the effectiveness of biomarkers under the accelerated failure time model. Two methods proposed by Shcemper et al. are deployed to measure the efficacy of biomarkers. We use simulations to explore how the factors can influence the power of a score test to detect the association of a longitudinal biomarker and the survival time. These factors include the functional form of the random effects from the longitudinal biomarkers, in the different number of individuals, and time points per individual. The simulations are used to explore how the number of individuals, the number of time points per individual influence the effectiveness of the biomarker to predict survival at the given endpoint under the accelerated failure time model. We illustrate our methods using a prothrombin index as a predictor of survival in liver cirrhosis patients.     

Tail Behavior and Limit Distribution of Maximum of Logarithmic General Error Distribution

Logarithmic general error distribution, an extension of the log-normal distribution, is proposed. Some interesting properties of the log GED are derived. These properties are applied to establish the asymptotic behavior of the ratio of probability densities and the ratio of the tails of the logarithmic general error and log-normal distributions, and to derive the asymptotic distribution of the partial maximum of an independent and identically distributed sequence obeying the log GED.     

Nonparametric Shrinkage Estimation for Aalen's Additive Hazards Model

Aalen's nonparametric additive model in which the regression coefficients are assumed to be unspecified functions of time is a flexible alternative to Cox's proportional hazards model when the proportionality assumption is in doubt. In this paper, we incorporate a general linear hypothesis into the estimation of the time‐varying regression coefficients. We combine unrestricted least squares estimators and estimators that are restricted by the linear hypothesis and produce James‐Stein‐type shrinkage estimators of the regression coefficients. We develop the asymptotic joint distribution of such restricted and unrestricted estimators and use this to study the relative performance of the proposed estimators via their integrated asymptotic distributional risks. We conduct Monte Carlo simulations to examine the relative performance of the estimators in terms of their integrated mean square errors. We also compare the performance of the proposed estimators with a recently devised LASSO estimator as well as with ridge‐type estimators both via simulations and data on the survival of primary billiary cirhosis patients.     

Transect-spacing design of ice cores on the Antarctic continent

Chemical analyses of ice cores, drilled deep into an ice sheet, provide a historical record of the earth's atmosphere that dates back as far as 400,000–500,000 years. Although the atmosphere mixes quite well, it is recognized that spatial variability associated with ice-core locations should be allowed for. In this article, spatial statistical methodology is applied to the design question of finding the best spacing of ice-core locations on a partial transect of Antarctica.     

A new class of measurement-error models,with applications to dietary data

Measurement-error modelling occurs when one cannot observe a covariate, but instead has possibly replicated surrogate versions of this covariate measured with error. The vast majority of the literature in measurement-error modelling assumes (typically with good reason) that given the value of the true but unobserved (latent) covariate, the replicated surrogates are unbiased for latent covariate and conditionally independent. In the area of nutritional epidemiology, there is some evidence from biomarker studies that this simple conditional independence model may break down due to two causes: (a) systematic biases depending on a person's body mass index, and (b) an additional random component of bias, so that the error structure is the same as a one-way random-effects model. We investigate this problem in the context of (1) estimating distribution of usual nutrient intake, (2) estimating the correlation between a nutrient instrument and usual nutrient intake, and (3) estimating the true relative risk from an estimated relative risk using the error-prone covariate. While systematic bias due to body mass index appears to have little effect, the additional random effect in the variance structure is shown to have a potentially important effect on overall results, both on corrections for relative risk estimates and in estimating the distribution of usual nutrient intake. However, the effect of dietary measurement error on both factors is shown via examples to depend strongly on the data set being used. Indeed, one of our data sets suggests that dietary measurement error may be masking a strong risk of fat on breast cancer, while for a second data set this masking is not so clear. Until further understanding of dietary measurement is available, measurement-error corrections must be done on a study-specific basis, sensitivity analyses should be conducted, and even then results of nutritional epidemiology studies relating diet to disease risk should be interpreted cautiously.     

On the usefulness of knowledge of error variances in the consistent estimation of an unreplicated ultrastructural model

This article considers an unreplicated ultrastructural model and discusses the asymptotic properties of three consistent estimators of slope parameter arising from the knowledge of measurement error variances. Conditions are deduced when knowing the error variances associated with both the study and the explanatory variables is more/less beneficial than using a single error variance in the formulation of slope estimators.     

Out-of-sample forecast errors in misspecific perturbed long memory processes

In this paper we examine the relative increase in mean square forecast error fro fitting a weakly stationary process to the series of interest when in fact the true model is a so-called perturbed long-memory process recently introduced by Granger and Marmol (1997). This model has the property of being unidentifiable from a white noise process on the basis of the correlogram and the usual rule-of-thumbs in the Box-Jenkins methodology. We prove that this kind of missspecification can lead to serious errors in terms of forecasting. We also show that corrections based on the AR(1) model can in some cases partially solve the problem. Received: March 15, 1999; revised version: February 14, 2000     

Order statistics from non-identical right-truncated Lomax random variables with applications

In this paper, we derive some recurrence relations for the single and the product moments of order statistics from n independent and non-identically distributed Lomax and right-truncated Lomax random variables. These recurrence relations are simple in nature and could be used systematically in order to compute all the single and product moments of all order statistics in a simple recursive manner. The results for order statistics from the multiple-outlier model (with a slippage of p observations) are deduced as special cases. We then apply these results by examining the robustness of censored BLUE's to the presence of multiple outliers. Received: November 30, 1998; revised version: March 8, 2000