Using In Vitro High‐Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards

Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high‐throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline‐based meta‐regression can be used to integrate data across multiple assay replicates to generate a concentration–response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk‐specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta‐regression, may allow risk assessors to identify points of departure and risk‐specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods.     

The role of titles in enhancing data visualization

Many in the data visualization and evaluation communities recommend conveying the message or takeaway of the visualization in the visualization's title. This study tested that recommendation by examining how informative or generic titles impact a visualization’s visual efficiency, aesthetics, credibility, and the perceived effectiveness of the hypothetical program examined. Furthermore, this study tested how simple or complex graphs, and positive, negative, or mixed results (i.e., valence of the results) affected outcomes. Participants were randomly assigned to one of 12 conditions, representing a 2 (graph: simple or complex) x 2 (title: generic or informative) x 3 (valence: positive, negative, mixed) between-subjects study. The results indicated that informative titles required less mental effort and were viewed as more aesthetically pleasing, but otherwise did not lead to greater accuracy, credibility, or perceived effectiveness. Furthermore, titles did not interact with graph type or the valence of the findings. While the results suggest it is worthwhile to consider adding an informative title to data visualizations as they can reduce mental effort for the viewer, the intended goal of the visualization should be taken into consideration. Considering the goal of the visualization can be a deciding factor of the type of graph and title that will best serve its intended purposes. Overall, this suggests that data visualization recommendations that impact evaluation reporting practices should be scrutinized more closely through research.     

Assessing emotional and social health using photographs: An innovative research method for rural studies and its applicability in a care-farming program for youth

A framework for assessing photographs for the emotional and social health of young people (SHAPE) is described and tested, within the context of a rural program. Two independent raters assessed the photographs of participants. To assess inter-rater reliability, Cohen’ K and Kendall’s W were calculated. The two reviewers’ assessments of photographs were in agreement. The assessment of emotional/behavioural display showed 82% agreement. Agreement between reviewers’ judgements of proxemics (W = .866), interaction (W = .722), engagement (W = .932) and overall impression (W = .804) were all significant (p < .005). The method yielded results indicating that participants found gardening immediately engaging but their approach to equines exhibited a change from fascination to confidence during the program. The visual-diary method is a useful and sensitive method for research: where resources are limited; to complement traditional measures; for use with people who lack appropriate verbal communication or literacy skills to complete questionnaires; young children; other underrepresented groups.     

More on plurality and authorship in science: A reply to Tang

Understanding the “political economy” of the research environment is at the core of getting clear on the ethical aspects of authorship. Questions about who should be an author on a scientific paper are complicated by the fact that authorship is used to determine credit inside science and by outside institutions whose interests and standards often differ dramatically. Much of the research ethics community seeks to impose an elite ethical consensus on scientific fields. I argue that this approach undermines the scientific autonomy of research communities. In contrast, we should develop bottom-up strategies that empower local communities and associations.     

近十年来我国旅游危机研究的回顾和反思简

2003年以来一系列外部突发事件对旅游业的影响和冲击，进一步印证了旅游业具有高敏感性和易波动性的特点，学术界愈加关注旅游危机领域的理论研究和实证分析。根据中国期刊全文数据库相关文献检索，本文回顾近十年来旅游危机研究的进展和成果，探讨当前研究现状及存在不足，为今后进一步拓展和深化该领域研究提供指导和借鉴。     

A call for action that cannot go to voicemail: Research activism to urgently improve Indigenous perinatal health and wellbeing

In this call to action, a coalition of Indigenous and non-Indigenous researchers from Australia, Aotearoa New Zealand, United States and Canada argue for the urgent need for adequately funded Indigenous-led solutions to perinatal health inequities for Indigenous families in well-resourced settler-colonial countries. Authors describe examples of successful community-driven programs making a difference and call on all peoples to support and resource Indigenous-led perinatal health services by providing practical actions for individuals and different groups.     

Fluctuating capacity of policy advice in Russia: testing theory in developing country context

ABSTRACT

Theories and concepts developed and empirically tested in the context of North American and Western European countries do not always easily transfer to another political landscape. The concept of “policy advisory system” is not an exception. On the one hand, policy processes and policy styles are not unique for each country; therefore, some generalizations can be made. On the other hand, studding particularities of policy process in a specific country can enrich theories, developed for general cases. Applying existing theories to a new context also goes a long way in verification and potential falsification – the fundamental requirement for a scientific process. This article aims to contribute to the debate on the topic of policy advisory system by comparing the development of three policies in Russia, each involving policy advisors to some extent. Based on this analysis, lessons are drawn regarding the conditions under which policy advisors can impact policy changes in an environment, alternative to “western.”     

全域旅游视角下的天府旅游名县竞争力研究——以四川省县域城市为例

天府旅游名县创建是按照全域旅游发展理念开展的，以建设世界重要旅游目的地为目标的建设工程。文章在系统整理旅游目的地竞争力主要研究成果基础上，建立15个天府旅游名县竞争力评价指标，基于可量化数据，采用主成分和聚类分析方法，对进入天府旅游名县的40个县(市、区）进行实证研究。结果显示，旅游核心竞争力、旅游发展规模、旅游综合实力、非优势资源品牌创建能力等因素是构成天府旅游名县评判的主要因子；从空间结构上看，呈现成都平原最强，川西、川北居中，川南最弱的局面；从创建动力上看，不应仅关注创建结果，而应通过创建工作，促进县域经济综合发展水平和城市发展潜力提升。     

Can Carbon Nanomaterials Improve CZTS Photovoltaic Devices? Evaluation of Performance and Impacts Using Integrated Life‐Cycle Assessment and Decision Analysis

In emergent photovoltaics, nanoscale materials hold promise for optimizing device characteristics; however, the related impacts remain uncertain, resulting in challenges to decisions on strategic investment in technology innovation. We integrate multi‐criteria decision analysis (MCDA) and life‐cycle assessment (LCA) results (LCA‐MCDA) as a method of incorporating values of a hypothetical federal acquisition manager into the assessment of risks and benefits of emerging photovoltaic materials. Specifically, we compare adoption of copper zinc tin sulfide (CZTS) devices with molybdenum back contacts to alternative devices employing graphite or graphene instead of molybdenum. LCA impact results are interpreted alongside benefits of substitution including cost reductions and performance improvements through application of multi‐attribute utility theory. To assess the role of uncertainty we apply Monte Carlo simulation and sensitivity analysis. We find that graphene or graphite back contacts outperform molybdenum under most scenarios and assumptions. The use of decision analysis clarifies potential advantages of adopting graphite as a back contact while emphasizing the importance of mitigating conventional impacts of graphene production processes if graphene is used in emerging CZTS devices. Our research further demonstrates that a combination of LCA and MCDA increases the usability of LCA in assessing product sustainability. In particular, this approach identifies the most influential assumptions and data gaps in the analysis and the areas in which either engineering controls or further data collection may be necessary.