未焊透缺陷安全尺寸的评价研究

未焊透是压力管道焊接接头常见缺陷之一,严重时会导致管道的承载能力明显降低,进而引发严重的安全事故。 目前我国的《在用工业管道定期检验规程》中对未焊透管道的定级是很保守的,为了减少对未焊透缺陷的返修,文章采 用非线性有限元分析的方法,通过简化未焊透管道的影响因素,并研究在不同载荷工况下管道失效模式与缺陷尺寸的关 系,获得了未焊透管道的极限载荷曲线簇;再运用塑性力学分析方法对有限元分析结果进行筛选,得到了焊接缺陷的安 全尺寸;最终通过试验验证极限载荷数值分析结果的合理性。研究结果表明含有超标焊接缺陷（如未焊透）的管道不通 过复杂应力计算和安全评定即可在保证安全前提下最大限度地使用。     

企业技术创新投入对产品质量的影响

不同规模的企业在技术创新和产品质量上均存在着明显的差异性,因而技术创新投入对产品质量的影响也可能随着企业规模的变化而呈现差异。基于调查数据的实证研究发现：中小型企业技术创新投入对其产品质量的提升具有显著的正效应,而大型企业技术创新投入对其产品质量提升的作用并不显著,显示出中小企业在以技术创新提升产品质量方面具有后发优势。研究建议,应保障中小型企业技术创新资金的有效供给,促进中小型企业共性技术支撑平台的建设,引导中小型企业构建产学研相结合的技术创新体系,培育和发展服务于中小型企业的科技服务中介机构,从而进一步发挥技术创新投入对中小型企业产品质量的提升作用。     

When is n large enough? Looking for the right sample size to estimate proportions

The central limit theorem indicates that when the sample size goes to infinite, the sampling distribution of means tends to follow a normal distribution; it is the basis for the most usual confidence interval and sample size formulas. This study analyzes what sample size is large enough to assume that the distribution of the estimator of a proportion follows a Normal distribution. Also, we propose the use of a correction factor in sample size formulas to ensure a confidence level even when the central limit theorem does not apply for these distributions.     

The effect of small sample on optimal designs for logistic regression models

Asymptotic methods are commonly used in statistical inference for unknown parameters in binary data models. These methods are based on large sample theory, a condition which may be in conflict with small sample size and hence leads to poor results in the optimal designs theory. In this paper, we apply the second order expansions of the maximum likelihood estimator and derive a matrix formula for the mean square error (MSE) to obtain more precise optimal designs based on the MSE. Numerical results indicate the new optimal designs are more efficient than the optimal designs based on the information matrix.     

Modelling period fertility: Schooling and intervals following a birth in Eastern Africa

We describe a regression-based approach to the modelling of age-, order-, and duration-specific period fertility, using retrospective survey data. The approach produces results that are free of selection biases and can be used to study differential fertility. It is applied to Demographic and Health Survey data for Ethiopia, Kenya, Tanzania, and Zimbabwe to investigate differential trends in fertility by education. Parity progression fell and the intervals following each birth lengthened between the 1970s and 2000s in all four countries. Fertility fell most among women with secondary education. In contrast to other world regions, postponement of successive births for extended periods accounted for much of the initial drop in fertility in these African countries. However, family size limitation by women with secondary education in Ethiopia and Kenya and longer birth spacing in Zimbabwe also played significant roles. Thus, birth control is being adopted in Eastern Africa in response to diverse changes in fertility preferences.     

Effects of Firm-specific and Country-specific Advantages on Relative Acquisition Size in Service Sector Cross-Border Acquisitions: An Empirical Examination

Using a sample of 348 service sector cross-border acquisitions by U.S. firms in 44 countries during 1990–2006, our study seeks to identify factors that influence relative acquisition size (acquisition transaction value as a percentage of acquiring firm's asset value). Our findings indicate that firm-specific advantages (FSAs) in the form of available financial slack and target industry knowledge were positively associated with relative acquisition size. However, contrary to expectations, we observed a negative relationship between cross-border acquisition experience and relative acquisition size. In addition, our results suggest that country-specific advantages (CSAs) associated with higher market potential, lower political risk, and greater cultural similarity contributed to increased relative acquisition size in service industry cross-border acquisitions. Finally, our analysis reveals that the relationship between available financial slack and relative acquisition size is contingent on cultural similarity with the relationship being more pronounced when cultural similarity is high.     

Family size and educational attainment in England and Wales

In this paper, we use linked census data from England and Wales to investigate whether having a large number of siblings leads to lower educational attainment. There is a large literature suggesting that with large sibship size, parental resources will be diluted and this, in turn, will lead to lower educational attainment. Using twin births and the sex composition of the sibling group as instrumental variables, we find that the evidence of a family size effect on educational attainment is rather uncertain. Similar results are obtained when we use occupational attainment as the dependent variable. We also demonstrate the confounding of birth order and family size effects, and show that an adjusted birth order index proposed by Booth and Kee provides an effective solution to this estimation problem.     

Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation

Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics.     

Quantile dispersion graphs to compare the efficiencies of cluster randomized designs

The purpose of this article is to compare efficiencies of several cluster randomized designs using the method of quantile dispersion graphs (QDGs). A cluster randomized design is considered whenever subjects are randomized at a group level but analyzed at the individual level. A prior knowledge of the correlation existing between subjects within the same cluster is necessary to design these cluster randomized trials. Using the QDG approach, we are able to compare several cluster randomized designs without requiring any information on the intracluster correlation. For a given design, several quantiles of the power function, which are directly related to the effect size, are obtained for several effect sizes. The quantiles depend on the intracluster correlation present in the model. The dispersion of these quantiles over the space of the unknown intracluster correlation is determined, and then depicted by the QDGs. Two applications of the proposed methodology are presented.     

Parental divorce, sibship size, family resources, and children’s academic performance

Using data from 19,839 adolescents from the National Education Longitudinal Study, this study investigates whether the effects of parental divorce on adolescents’ academic test performance vary by sibship size. Analyses show that the negative effect of divorce on adolescent performance attenuates as sibship size increases. On the other side of the interaction, the inverse relationship between sibship size and test performance is weaker in disrupted than in two-biological-parent families. Trends of such interactions are evident when sibship size is examined either as a continuous or a categorical measure. Finally, the observed interactions on adolescents’ academic performance are completely explained by variations in parental financial, human, cultural, and social resources. In sum, this study underlines the importance of treating the effect of parental divorce as a variable and calls for more research to identify child and family features that may change the magnitude of such an effect.