Robust Bayesian nonlinear mixed‐effects modeling of time to positivity in tuberculosis trials

Early phase 2 tuberculosis (TB) trials are conducted to characterize the early bactericidal activity (EBA) of anti‐TB drugs. The EBA of anti‐TB drugs has conventionally been calculated as the rate of decline in colony forming unit (CFU) count during the first 14 days of treatment. The measurement of CFU count, however, is expensive and prone to contamination. Alternatively to CFU count, time to positivity (TTP), which is a potential biomarker for long‐term efficacy of anti‐TB drugs, can be used to characterize EBA. The current Bayesian nonlinear mixed‐effects (NLME) regression model for TTP data, however, lacks robustness to gross outliers that often are present in the data. The conventional way of handling such outliers involves their identification by visual inspection and subsequent exclusion from the analysis. However, this process can be questioned because of its subjective nature. For this reason, we fitted robust versions of the Bayesian nonlinear mixed‐effects regression model to a wide range of TTP datasets. The performance of the explored models was assessed through model comparison statistics and a simulation study. We conclude that fitting a robust model to TTP data obviates the need for explicit identification and subsequent “deletion” of outliers but ensures that gross outliers exert no undue influence on model fits. We recommend that the current practice of fitting conventional normal theory models be abandoned in favor of fitting robust models to TTP data.     

Can the welfare state replace parents? Children's cognition in the United States and Great Britain

We compare family and parental effects on child verbal facility, verbal achievement and mathematics achievement in the United States and Great Britain. We study 3,438 5–13 year-old children from the 1994 NLSY Child-Mother Data Set and 1429 same-aged children from the National Child Development Study, also known as the British Child. Multivariate analyses suggest that the processes through which families invest in child cognition are similar across societies, with factors including low birth weight, child health, maternal cognition, family size and children's home environments being consequential. We conclude that parental investments are equally important across the two societies. The more developed welfare state in Great Britain does not notably compensate for parental investments in that society, although it may play a greater role when parental resources are absent or stretched thin.     

The impact of internal communication on strategic and economic effects in Serbian companies

This paper presents the research results in relation to examining and defining dependences and the impact of internal communication on certain strategic and economic business effects. Serbian companies were the focus of this research. The data were collected by polling 100 managers from 100 companies. Afterwards, multivariate regression and correlation was carried out in the aim of the final determination of requested dependences. This research confirmed a strong positive relation between internal communication and strategic and economic business effects.     

A permutation alternative and other test procedures for spatially correlated data in one-way anova

Research in many disciplines involves data with spatially correlated observations. Spatial dependence violates the independent errors assumption required for techniques such as the standard one-way analysis of variance for a completely randomized design. The testing methodology within the correlated errors approach has not been investigated within a spatial context. For one-way fixed effects analysis of variance, a permutation test and tests associated with the correlated errors approach are investigated through simulation. No single test was superior with respect to both power and size but the standard Wald F test and a simple adjustment to it performed well overall.     

Maximum likelihood estimation for generalized conditionally autoregressive models of spatial data

Conditionally autoregressive (CAR) models are often used to analyze a spatial process observed over a lattice or a set of irregular regions. The neighborhoods within a CAR model are generally formed deterministically using the inter-distances or boundaries between the regions. To accommodate directional and inherent anisotropy variation, a new class of spatial models is proposed that adaptively determines neighbors based on a bivariate kernel using the distances and angles between the centroid of the regions. The newly proposed model generalizes the usual CAR model in a sense of accounting for adaptively determined weights. Maximum likelihood estimators are derived and simulation studies are presented for the sampling properties of the estimates on the new model, which is compared to the CAR model. Finally the method is illustrated using a data set on the elevated blood lead levels of children under the age of 72 months observed in Virginia in the year of 2000.     

The effect of sociodemographic (mis)match between interviewers and respondents on unit and item nonresponse in Belgium

Interviewer characteristics affect nonresponse and measurement errors in face-to-face surveys. Some studies have shown that mismatched sociodemographic characteristics – for example gender – affect people's behavior when interacting with an interviewer at the door and during the survey interview, resulting in more nonresponse. We investigate the effect of sociodemographic (mis)matching on nonresponse in two successive rounds of the European Social Survey in Belgium. As such, we replicate the analyses of the effect of (mis)matching gender and age on unit nonresponse on the one hand, and of gender, age and education level (mis)matching on item nonresponse on the other hand. Recurring effects of sociodemographic (mis)match are found for both unit and item nonresponse.     

Testing variance components in balanced linear growth curve models

It is well known that the testing of zero variance components is a non-standard problem since the null hypothesis is on the boundary of the parameter space. The usual asymptotic chi-square distribution of the likelihood ratio and score statistics under the null does not necessarily hold because of this null hypothesis. To circumvent this difficulty in balanced linear growth curve models, we introduce an appropriate test statistic and suggest a permutation procedure to approximate its finite-sample distribution. The proposed test alleviates the necessity of any distributional assumptions for the random effects and errors and can easily be applied for testing multiple variance components. Our simulation studies show that the proposed test has Type I error rate close to the nominal level. The power of the proposed test is also compared with the likelihood ratio test in the simulations. An application on data from an orthodontic study is presented and discussed.     

Exact and approximate distributions for linear contrasts of means and variances

A Bayesian analysis is presented for the K-group Behrens-Fisher problem. Both exact posterior distributions and approximations were developed for both a general linear contrast of the K means and the K variances, given either proper diffuse or informative conjugate priors. The contrast of variances is a unique feature of the heterogeneous variance model that enables investigators to test specific effects of experimental manipulations on variance. Finally, important-differences were observed between the heterogeneous variance model and the homogeneous model.     

On the existence of linear trend free block designs

We present a class of counerexamples for a conjecture on the existence or linear trend free block designs we will also prove a considerably weakened version of this conjecture which will determine all combinations of designs parmetres for which the class of linear trend free block designs is non empty.     

外商直接投资对民族地区经济的影响及对策

目前对于民族地区吸收FD I(外商直接投资),学界尚存在着许多错误看法,这些看法片面地夸大外国直接投资给民族地区带来的好处,低估甚至根本抹煞它对民族经济的负面影响。认为FD I对民族地区的经济发展只存在正面效应,因此主张越多越好。笔者认为,对于FD I对民族经济的影响应该从正、反两方面进行考察,应客观地剖析两大利益主体之间的博弈。