Orthogonally Blocked Mixture Experiments in Ellipsoidal Restricted Regions

In practical situations involving mixtures formed from several ingredients, interest is sometimes centered on the response in an ellipsoidal neighborhood around a standard formulation. We show that standard, orthogonally blocked, response surface designs, defined on a q ? 1 dimensional unit sphere, may be transformed into similarly orthogonally blocked q-ingredient mixture designs defined within an ellipsoid centered at the standard formulation. The method is illustrated using several examples of mixture experiments with three, four, and five ingredients, arranged in two, three, or four orthogonal blocks, obtained by projecting standard central composite designs and Box–Behnken designs into the ellipsoidal mixture region. Rotations of the resulting designs within the ellipsoidal regions are also considered.     

On Sharp Jensen's Inequality and Some Unusual Applications

The purpose of this article is two-fold. First, we find it very interesting to explore a kind of notion of optimality of the customary Jensen-bound among all Jensen-type bounds. Without this result, the customary Jensen-bound stood alone simply as just another bound. The proposed notion and the associated optimality are important given that in some situations the Jensen's inequality does leave us empty handed.

When it comes to highlighting Jensen's inequality, unfortunately only a handful of nearly routine applications continues to recycle time after time. Such encounters rarely produce any excitement. This article may change that outlook given its second underlying purpose, which is to introduce a variety of unusual applications of Jensen's inequality. The collection of our important and useful applications and their derivations are new.     

Lower and Upper Bounds for Rectangular Probabilities

This article presents some results showing how rectangular probabilities can be studied using copula theory. These results lead us to develop new lower and upper bounds for rectangular probabilities which can be computed efficiently. The new bounds are compared with the ones obtained from the generalized Fréchet–Hoeffding bounds and Bonferroni-type inequalities.     

Shannon Information Properties of the Endpoints of Record Coverage

This paper addresses the largest and the smallest observations, at the times when a new record of either kind (upper or lower) occurs, which are it called the current upper and lower record, respectively. We examine the entropy properties of these statistics, especially the difference between entropy of upper and lower bounds of record coverage. The results are presented for some common parametric families of distributions. Several upper and lower bounds, in terms of the entropy of parent distribution, for the entropy of current records are obtained. It is shown that mutual information, as well as Kullback–Leibler distance between the endpoints of record coverage, Kullback–Leibler distance between data distribution, and current records, are all distribution-free.     

Hypothesis Tests for Covariance Analysis Models for Circular Data

We introduce covariance analysis models for circular dependent variables. In addition, we have also developed hypothesis tests to evaluate the significance of the parameters used. One of the tests is an extension of the Watson–Williams test. The tests performances have been evaluated using simulation studies.     

IPPS Sampling Plans Excluding Adjacent Units

The concept of inclusion probability proportional to size sampling plans excluding adjacent units separated by at most a distance of m (≥ 1) units {IPPSEA plans} is introduced. IPPSEA plans ensure that the first-order inclusion probabilities of units are proportional to size measures of the units, while the second-order inclusion probabilities are zero for pairs of adjacent units separated by a distance of m units or less. IPPSEA plans have been obtained by making use of binary, proper, and unequireplicated block designs and linear programing approach. The performance of IPPSEA plans using Horvitz–Thompson estimator of population total has been compared with existing sampling plans such as simple random sampling without replacement (SRSWOR), balanced sampling plans excluding adjacent units {BSA (m) plans}, probability proportional to size with replacement, Hartley and Rao's plan (1962 Hartley , H. O. , Rao , J. N. K. ( 1962 ). Sampling with unequal probabilities and without replacement . Ann. Math. Statist. 33 : 350 – 374 .[Crossref] , [Google Scholar]), Rao et al.'s strategy (1962 Rao , J. N. K. , Hartley , H. O. , Cochran , W. G. ( 1962 ). On a simple procedure of unequal probability sampling without replacement . J. Roy. Statist. Soc. B 24 : 482 – 491 . [Google Scholar]), and Sampford's IPPS plan (1967 Sampford , M. R. ( 1967 ). On sampling without replacement with unequal probabilities of selection . Biometrika 54 ( 3 ): 499 – 513 .[Crossref], [PubMed] , [Google Scholar]) using a real life population. Unbiased estimation of Horvitz–Thompson estimator of population total is not possible in these types of plans because some of the second-order inclusion probabilities are zero. To resolve this problem, one approximate variance estimation technique has been suggested.     

Presmoothed Estimation with Left-Truncated and Right-Censored Data

We propose a new method to estimate the cumulative hazard function and the corresponding distribution function of survival times under randomly left-truncated and right-censored observations (LTRC). The new estimators are based on presmoothing ideas, the estimation of the conditional expectation m of the censoring indicator. An almost sure representation for both estimators is established, from which a strong consistency rate and asymptotic normality are derived. It is shown that the presmoothed modification leads to a gain in terms of asymptotic mean squared error. This efficiency with respect to the classical estimators is also shown in a simulation study. Finally, an application to a real data set is provided.     

Comparing Equal-Tail Probability and Unbiased Confidence Intervals for the Intraclass Correlation Coefficient

The conventional confidence interval for the intraclass correlation coefficient assumes equal-tail probabilities. In general, the equal-tail probability interval is biased and other interval procedures should be considered. Unbiased confidence intervals for the intraclass correlation coefficient are readily available. The equal-tail probability and unbiased intervals have exact coverage as they are constructed using the pivotal quantity method. In this article, confidence intervals for the intraclass correlation coefficient are built using balanced and unbalanced one-way random effects models. The expected length of confidence intervals serves as a tool to compare the two procedures. The unbiased confidence interval outperforms the equal-tail probability interval if the intraclass correlation coefficient is small and the equal-tail probability interval outperforms the unbiased interval if the intraclass correlation coefficient is large.     

Relative Curvature Measure for Heteroscedastic or Non Normal Nonlinear Regression

The Bates–Watts relative curvature measure can assess the validity of the linearized approximation in nonlinear regression models. However, it is developed based on an ordinary nonlinear regression in which the observation is assumed to be homoscedastically and normally distributed. In this article, we extend the original Bates–Watts relative curvature measure to one that can be applicable to nonlinear regression with heteroscedastic or non normal data, based on the transformation-both-sides (TBS) approach. In pharmacokinetic models, a diagnostic use of their measures is illustrated. By means of a simulation experiment, the performance of the relative curvature measure for the TBS approach is evaluated.