TP与GP化疗方案对肺癌患者骨髓抑制影响的Meta分析

目的通过Meta分析对紫杉醇+顺铂(TP)与吉西他滨+顺铂(GP)化疗方案对肺癌抗肿瘤药物治疗患者骨髓抑制的影响进行系统分析,探讨TP和GP的骨髓抑制差别。方法通过荟萃分析对TP与GP的骨髓抑制研究进行同质性检验和合并效应量的估计。结果同质性检验:χ2=91.84,自由度为29,P0.00001;合并效应量的估计:OR合并=1.36,OR合并95%可信限为0.90~2.04。OR合并的检验Z=1.482.41,P=0.14。结论 TP与GP化疗时对患者的骨髓抑制不良反应情况没有本质区别。     

释"毛"、"舞"

先秦典籍中,“毛”字含义有三:毛发与兽毛之类;草类;五谷。金文和《说文》中的“毛”,字形像谷子。“毛”字的基本含义就是“五谷”。甲骨文中无“毛”字而有“舞”字,“舞”字中一人所执之物非一般所释的“牛尾”,而是倒执的“毛”,即五谷。“舞”是古人在谷物成熟后执禾而舞。     

汐翁《龟甲文》与甲骨文的发现

汐翁早年发表的《龟甲文》一文在甲骨学界影响甚大。虽然部分记述出入不多,但其中关于甲骨文的发现离奇而不符合事实,还有的是信笔由之,引用者应辨析使用。     

“五字诀”优化骨髓穿刺培训体系

骨髓穿刺术是临床常用的四大穿刺术之一,对相关疾病的诊断、治疗和预后有重要意义,但其对操作者理论、技能和心理素质的要求均较高。医学实习生刚刚接触临床,如按照以往的方式教学,熟练掌握骨穿技术需要较长时间。作者以独创的“骨穿五字诀一净准好直快”为核心,实施循证教学,突破了以往的教学瓶颈,在大规模培训中取得了良好的效果。     

Quantile residual life regression based on semi-competing risks data

This paper investigates the quantile residual life regression based on semi-competing risk data. Because the terminal event time dependently censors the non-terminal event time, the inference on the non-terminal event time is not available without extra assumption. Therefore, we assume that the non-terminal event time and the terminal event time follow an Archimedean copula. Then, we apply the inverse probability weight technique to construct an estimating equation of quantile residual life regression coefficients. But, the estimating equation may not be continuous in coefficients. Thus, we apply the generalized solution approach to overcome this problem. Since the variance estimation of the proposed estimator is difficult to obtain, we use the bootstrap resampling method to estimate it. From simulations, it shows the performance of the proposed method is well. Finally, we analyze the Bone Marrow Transplant data for illustrations.     

Estimating the prevalence of low-lumbar spine bone mineral density in older men with or at risk for HIV infection using normal mixture models

Bone mineral density decreases naturally as we age because existing bone tissue is reabsorbed by the body faster than new bone tissue is synthesized. When this occurs, bones lose calcium and other minerals. What is normal bone mineral density for men 50 years and older? Suitable diagnostic cutoff values for men are less well defined than for women. In this paper, we propose using normal mixture models to estimate the prevalence of low-lumbar spine bone mineral density in men 50 years and older with or at risk for human immunodeficiency virus infection when normal values of bone mineral density are not generally known. The Box–Cox power transformation is used to determine which transformation best suits normal mixture distributions. Parametric bootstrap tests are used to determine the number of mixture components and to determine whether the mixture components are homoscedastic or heteroscedastic.     

The predictive role of bone turnover markers for BMD in middle-aged men

Measurement of bone turnover markers has been proposed as a potentially valuable clinical laboratory aid in osteoporosis risk assessment. These markers may allow quantitative evaluation of rates of bone loss, and thereby identify persons at risk for osteoporosis at an earlier stage. As far as we know, this is the longest longitudinal study on bone turnover markers conducted in adult men. The objectives of this study were to determine whether markers of bone formation (type I procollagen amino-terminal propeptide, PINP, and carboxy-terminal propeptide, PICP), and of bone resorption (type I collagen carboxy-terminal telopeptide, ICTP), are predictive of changes in lumbar spine and femoral neck BMD over a 5-year period, and to determine the ability of the bone resorption marker urine amino-terminal telopeptide (NTx) to explain the variance in BMD change over the past 5 years in a group of men 35–69 years old. In this group, NTx was the only marker to correlate significantly with BMD changes at the femoral neck (r = ?0.21), but not at the spine. The use of the biochemical markers studied to predict change in bone density in adult men in middle-aged years is of very limited value.     

Alzheimer's Disease and Older Women

The graying of America suggests that dementia will become "the epidemic of the 21st century." First described in 1907, Alzheimer's Disease (AD) accounts for an estimated two-thirds of all dementia. AD currently has no cure, thus causing a major drain on health care and family resources. Compared to men, women are uniquely affected by AD due to their gender-associated increased risk, longer life span, and roles as caregivers within families and institutions. Living successfully with dementia requires medical and behavioral interventions to manage disruptive symptoms, knowledge to optimize environmental conditions, and caregiver support and savvy to avoid burnout. Strategies for maximizing functioning in older women living with AD are provided.     

框架刚性连接梁柱节点抗震性能研究

通常认为钢框架具有良好的抗震性能,但在最近的几次大地震中许多高层钢结构房屋的梁柱连接节点处发生严重的破坏。这说明传统的刚性连接框架在某些方面存在着不足之处。对刚性节点的形式以及抗震的能力进行探讨,并作出改进的措施,给以后的设计、施工提出意见和建议。     

“王若曰”新考

“王若曰”是先秦典籍和金文材料中比较常见的词语。对该词语的释义,目前仍未取得一致意见。通过对金文、简牍和传世典籍中的相关资料进行考察和梳理,可知“王若曰”不是王一般的谈话,而主要是指王命,语感在强调其庄严性。此外,学者以往举出的殷墟甲骨文中“王若曰”的例证并不可靠,从现有材料来看,“王若曰”可能是周人的说法。