基于随机p-鲁棒优化的国家血液战略储备库选址-库存模型

以往的救灾实践对建立国家血液战略储备体系提出了迫切要求。国家血液战略储备库的建设问题亟待解决。由于血液产品特性以及应急血液保障特性的存在,使得国家血液战略储备库的选址决策具有一定的复杂性。本文将问题定位为选址-库存问题。首先,以应急条件下血液保障及时度最高为目标,构建了一个不确定环境下考虑多情景、多血型、多阶段、带提前期、有容量限制、日常随机需求、有预算约束及协同定位的国家血液战略储备库选址-库存模型。同时,为了规避应急条件下的不确定风险,进一步构建了国家血液战略储备库选址-库存问题的随机p-鲁棒优化模型。该模型为离散非线性混合整数规划模型,难以快速精确求解。故基于模型性质,设计了相应的遗传算法。最后,设计了两组算例验证模型与算法的有效性。其中,第1组算例基于我国大陆地区31个省级血液中心与省级行政区的数据,并根据不同预算值给出6个算例,得到了国家血液战略储备库的选址-库存决策方案。第2组算例为6个不同规模的模拟算例,用来测试不同规模下的算法性能。算例结果表明：遗传算法的性能更好;鲁棒解与确定性模型最优值相差不大（最大差距≤1.08%）,可降低不确定性导致的风险。实践中,可对本文所建模型稍作改进,应用于具有类似特征的易腐品（药品、粮食等）应急物资储备库选址-库存决策。     

Testing an Integrative Contextual Career Development Model With Adolescents From High‐Poverty Urban Areas

Variations in the economic recovery rate across the United States have led to even greater chasms that separate the employed, unemployed, and underemployed (DeSilver, 2017 ). Therefore, understanding and supporting the career development of future generations is critical—especially for those who live outside the context of social privilege. The authors examined the applicability of the integrative contextual model of career development (ICM; Lapan, 2004 ) to a sample of 220 adolescents (129 boys, 91 girls) from a high‐poverty urban area. Results indicated that a canonical variate comprising foundational ICM skills (e.g., career exploration, goal setting) predicted a variate composed of ICM outcomes (e.g., self‐efficacy, vocational identity), thus supporting the usefulness of the ICM framework for this population. The skill of setting viable career goals was an especially strong predictor of outcomes. Implications for career counseling with adolescents living in high‐poverty urban areas and directions for future research are discussed.     

Generalized Augmentation to Control the False Discovery Exceedance in Multiple Testing

Abstract.  A new multiple testing procedure, the generalized augmentation procedure (GAUGE), is introduced. The procedure is shown to control the false discovery exceedance and to be competitive in terms of power. It is also shown how to apply the idea of GAUGE to achieve control of other error measures. Extensions to dependence are discussed, together with a modification valid under arbitrary dependence. We present an application to an original study on prostate cancer and on a benchmark data set on colon cancer.     

A clarifying comparison of methods for controlling the false discovery rate

Traditional multiple hypothesis testing procedures fix an error rate and determine the corresponding rejection region. In 2002 Storey proposed a fixed rejection region procedure and showed numerically that it can gain more power than the fixed error rate procedure of Benjamini and Hochberg while controlling the same false discovery rate (FDR). In this paper it is proved that when the number of alternatives is small compared to the total number of hypotheses, Storey's method can be less powerful than that of Benjamini and Hochberg. Moreover, the two procedures are compared by setting them to produce the same FDR. The difference in power between Storey's procedure and that of Benjamini and Hochberg is near zero when the distance between the null and alternative distributions is large, but Benjamini and Hochberg's procedure becomes more powerful as the distance decreases. It is shown that modifying the Benjamini and Hochberg procedure to incorporate an estimate of the proportion of true null hypotheses as proposed by Black gives a procedure with superior power.     

谈高校英语专业口译测试的规范化设计

口译测试是检测考生口译能力并获取教学反馈信息的重要手段。本文分析了当前高校口译测试中存在的问题,并以交际测试理论为指导,对口译测试的原则、内容、题型和评分标准等问题进行了综合研究和探讨,在此基础上对高校口译测试的规范设计和合理实施提出了具体建议和方案。     

中国C2C电子商务网站的用户体验

通过学生用户试用在两个不同文化背景下设计出来的C2C电子商务网站——淘宝网和Ebay易趣,并进行初次网上购物体验活动,以及对测试后满意度问卷的分析,结果显示:在用户决定购买的过程中,网站概念/功能的传递和表达对用户的影响最大,它们会影响到用户的初次购买决定;而流程的跳转以及交互行为的不平衡会对用户的购买过程造成影响;对用户初次购物总体评价影响最大的是功能满足。两个网站的系统可用性与界面设计不能决定用户的总体评价,但却会影响到用户对网站的感觉。因此,创建一个对用户有用、好用和想用的购物网站就必须要满足功能、交互以及冲击三个层次的要求。     

‘Warren Buffet is my cousin’: shaping public understanding of big data biotechnology,direct-to-consumer genomics,and 23andMe on Twitter

Scholars, educators, regulators, pundits, and other observers are advocating for regulation and oversight of direct-to-consumer (DTC) genomic testing. As a result, the technology has been subject of highly visible public and regulatory controversy. In this article, we explore the nature and the shape of the sentiment of public discourse about the DTC company, 23andMe. We conduct a quantitative content analysis and qualitative framing analysis on Tweets. We find that the discourse surrounding DTC genomics and 23andMe is largely positive. We also identify a number of frames users deploy to debate, discuss, and share their experiences with DTC genomics and 23andMe. We argue that these frames create meaning around this emerging technology for its users.     

Sexual orientation differences in HIV testing motivation among college men

Objective: To investigate sexual orientation differences in college men's motivations for HIV testing. Participants: 665 male college students in the Southeastern United States from 2006 to 2014. Methods: Students completed a survey on HIV risk factors and testing motivations. Logistic regressions were conducted to determine the differences between heterosexual men (HM) and sexual minority men (SMM). Results: SMM were more motivated to get tested by concern over past condomless sex, while HM were more often cited supporting the testing program “on principle” and wanting a free t-shirt. SMM and HM differed in behaviors that impact HIV risk and other demographics. However, differences in testing motivation by concern over past condomless sex or wanting a free t-shirt persisted when controlling for these demographic and behavioral differences. Conclusions: Appropriately designed HIV prevention interventions on college campuses should target SMM's distinct concern over past condomless sex as a testing motivation.