A qualitative case study of a Korean former addict’s existential self‐interpretation and identity transformation

This study explored the case of a former addict, focusing on his existential self‐interpretation and identity transformation process. This study began from the question of whether philosophical processes related to existential self‐interpretation could lead to the formation of the concept of bottoming out and of identity transformation. To answer this question, the study analyzed the case of a male in his mid‐forties who was addicted to drugs for approximately 30 years and has only recently maintained abstinence. The study used the phenomenological approach to determine the meaning drugs held for him in each stage, and what drug‐related identity he had in each stage. Further, this study identified the integrative implications of these meanings in terms of existential self‐interpretation and identity transformation. The four different identities the man identified for the four stages of his life were juvenile delinquent, gang member, half‐gangster, and breadwinner, and the associated meanings drugs had for him during each period were “glue,” “filthy,” “leeches,” and “abstinence,” respectively. Finally, this study elucidated the integration of these meanings through the hermeneutic circle, identified the social welfare implications of the findings, and developed educational recommendations.     

人口较少民族经济向现代经济转变的路径分析

在阐述路径依赖理论的基础上,结合人口较少民族经济的特点对人口较少民族经济向现代经济转变的路径进行了分析,提出要辩证地看待人口较少民族传统经济在这一转变中的影响和作用,认为人口较少民族实现经济转变的首要问题是打破经济封闭和信息封闭,在此基础上,将自身的特色优势与区域优势有效结合起来,将传统经济中的积极因素与现代经济因素有效结合起来,走因地制宜、循序渐进的转变路径。     

情景依赖对消费者品牌延伸评价的影响

品牌延伸是新产品入市的重要手段。文章从信息储存和使用的角度对品牌认知结构和情景依赖水平如何影响消费者的品牌延伸评价进行了研究,并探讨了不同沟通方式(关系型和阐释型)对不同情景依赖水平消费者品牌延伸评价的影响。研究发现:情景独立的消费者,相对于情景依赖的消费者会有更积极的品牌延伸评价和更好的品牌延伸匹配度感知;关系型沟通能使情景独立者产生更积极的品牌延伸评价和更好的品牌延伸匹配度感知;阐释型沟通能使情景依赖者产生更积极的品牌延伸评价和更好的品牌延伸匹配度感知。     

走私毒品罪若干问题研究

走私毒品罪在我国司法实践中是一种比较常见、多发的犯罪,对于走私毒品犯罪进行打击非常必要.这是因为该罪不仅违反了国家对毒品管制的法律、法规,而且违反了国家海关管理法律、法规,在客观上实施了将毒品进出国(边)境的行为.因此,其对国家的外贸和毒品管制危害极大.为了有效地打击和惩治该种犯罪,从理论上弄清本罪的概念,从犯罪构成要件上来把握本罪的特征,正确地把握本罪与非罪、此罪与彼罪、犯罪的罪数形态、共犯形态和停止形态,对于司法机关正确地认定本罪具有非常重要的意义.     

取消药品加成对公立医院运行机制的影响及对策分析

取消药品加成是新医改药品领域改革的核心,历经六十余年的药品加成政策将要全面取消。文章梳理了药品加成政策的历史背景及改革变迁之路;分析了在一定历史时期药品加成政策对我国公立医院发展作出的积极贡献,以及药品加成政策造成"以药养医"、加剧"看病贵"等负面影响;总结了在新时期取消药品加成政策给公立医院的收入、运行效率和药学部门人才队伍培养等带来的挑战。针对各级公立医院在"药品零加成"的改革中遇到收入模式转变、医务人员积极性受挫等现实问题,给予了针对性的对策和建议,以便完善公立医院运行管理,谋求更加长远的发展。     

Exploring Shame,Guilt, and Risky Substance Use Among Sexual Minority Men and Women

This study examined the interrelations among shame-proneness, guilt-proneness, internalized heterosexism (IH), and problematic substance use among 389 gay, lesbian, and bisexual men and women. Problematic alcohol and drug use were positively related to shame-proneness and negatively related to guilt-proneness. Bisexuals reported riskier substance use behaviors, lower levels of guilt-proneness, and higher levels of IH than gay men and lesbians. Furthermore, study findings indicated that shame and IH are related. Additional investigations of these associations would supplement current understandings of sexual minority stress and advance the development of substance-related intervention and prevention efforts targeting sexual minorities.     

刑事诉讼法修正后毒品犯罪案件证据制度的完善

由于毒品犯罪案件有其特殊性,其证据的取得、认定、运用等多方面存在诸多困难。新颁布的《刑事诉讼法修正案》增加了电子证据种类,肯定了"控制下交付"的侦查措施,明确了证人出庭保护等制度,为今后查办和认定毒品犯罪案件提供新的保障,当然也提出了新问题。     

Adaptive phase I/II clinical trials for drug combination assessment in oncology using the outcomes of each cycle

Many new anticancer agents can be combined with existing drugs, as combining a number of drugs may be expected to have a better therapeutic effect than monotherapy owing to synergistic effects. Furthermore, to drive drug development and to reduce the associated cost, there has been a growing tendency to combine these as phase I/II trials. With respect to phase I/II oncology trials for the assessment of dose combinations, in the existing methodologies in which efficacy based on tumor response and safety based on toxicity are modeled as binary outcomes, it is not possible to enroll and treat the next cohort of patients unless the best overall response has been determined in the current cohort. Thus, the trial duration might be potentially extended to an unacceptable degree. In this study, we proposed a method that randomizes the next cohort of patients in the phase II part to the dose combination based on the estimated response rate using all the available observed data upon determination of the overall response in the current cohort. We compared the proposed method to the existing method using simulation studies. These demonstrated that the percentage of optimal dose combinations selected in the proposed method is not less than that in the existing method and that the trial duration in the proposed method is shortened compared to that in the existing method. The proposed method meets both ethical and financial requirements, and we believe it has the potential to contribute to expedite drug development.