Functional Partial Linear Single‐index Model

This paper deals with the problem of predicting the real‐valued response variable using explanatory variables containing both multivariate random variable and random curve. The proposed functional partial linear single‐index model treats the multivariate random variable as linear part and the random curve as functional single‐index part, respectively. To estimate the non‐parametric link function, the functional single‐index and the parameters in the linear part, a two‐stage estimation procedure is proposed. Compared with existing semi‐parametric methods, the proposed approach requires no initial estimation and iteration. Asymptotical properties are established for both the parameters in the linear part and the functional single‐index. The convergence rate for the non‐parametric link function is also given. In addition, asymptotical normality of the error variance is obtained that facilitates the construction of confidence region and hypothesis testing for the unknown parameter. Numerical experiments including simulation studies and a real‐data analysis are conducted to evaluate the empirical performance of the proposed method.     

An F-type test for detecting departure from monotonicity in a functional linear model

When studying associations between a functional covariate and scalar response using a functional linear model (FLM), scientific knowledge may indicate possible monotonicity of the unknown parameter curve. In this context, we propose an F-type test of monotonicity, based on a full versus reduced nested model structure, where the reduced model with monotonically constrained parameter curve is nested within an unconstrained FLM. For estimation under the unconstrained FLM, we consider two approaches: penalised least-squares and linear mixed model effects estimation. We use a smooth then monotonise approach to estimate the reduced model, within the null space of monotone parameter curves. A bootstrap procedure is used to simulate the null distribution of the test statistic. We present a simulation study of the power of the proposed test, and illustrate the test using data from a head and neck cancer study.     

Coherent mortality forecasting by the weighted multilevel functional principal component approach

In human mortality modelling, if a population consists of several subpopulations it can be desirable to model their mortality rates simultaneously while taking into account the heterogeneity among them. The mortality forecasting methods tend to result in divergent forecasts for subpopulations when independence is assumed. However, under closely related social, economic and biological backgrounds, mortality patterns of these subpopulations are expected to be non-divergent in the future. In this article, we propose a new method for coherent modelling and forecasting of mortality rates for multiple subpopulations, in the sense of nondivergent life expectancy among subpopulations. The mortality rates of subpopulations are treated as multilevel functional data and a weighted multilevel functional principal component (wMFPCA) approach is proposed to model and forecast them. The proposed model is applied to sex-specific data for nine developed countries, and the results show that, in terms of overall forecasting accuracy, the model outperforms the independent model and the Product-Ratio model as well as the unweighted multilevel functional principal component approach.     

Linear scalar-on-surface random effects regression models

Many research fields increasingly involve analyzing data of a complex structure. Models investigating the dependence of a response on a predictor have moved beyond the ordinary scalar-on-vector regression. We propose a regression model for a scalar response and a surface (or a bivariate function) predictor. The predictor has a random component and the regression model falls in the framework of linear random effects models. We estimate the model parameters via maximizing the log-likelihood with the ECME (Expectation/Conditional Maximization Either) algorithm. We use the approach to analyze a data set where the response is the neuroticism score and the predictor is the resting-state brain function image. In the simulations we tried, the approach has better performance than two other approaches, a functional principal component regression approach and a smooth scalar-on-image regression approach.     

Uniform consistency rate of kNN regression estimation for functional time series data

In this paper, we investigate the k-nearest neighbours (kNN) estimation of nonparametric regression model for strong mixing functional time series data. More precisely, we establish the uniform almost complete convergence rate of the kNN estimator under some mild conditions. Furthermore, a simulation study and an empirical application to the real data analysis of sea surface temperature (SST) are carried out to illustrate the finite sample performances and the usefulness of the kNN approach.     

Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia

Introduction: Tadalafil is a promising phosphodiesterase (PDE) 5 inhibitor prescribed for erectile dysfunction (ED). Daily low dose (5?mg) of tadalafil has also been used for the treatment of male lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH). PDE5 inhibitors induce relaxation of smooth muscle cells in the urethra, prostate, bladder neck, and blood vessels. The aim of this study was to investigate the efficacy of tadalafil on vessels endothelial function, in patients with male LUTS symptoms associated with BPH.

Methods: The Institutional Review Board (IRB) approved this clinical study and informed consents had been obtained from 81 BPH patients.

The following male LUTS parameters: international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), voiding volume, max and mean voiding flow on voiding flowmetry examination and post-voiding residual urine (RU) were compared at 0, 1, 3, 6, and 12 months after a daily dose of 5?mg tadalafil.

In addition, erectile function was evaluated by the sexual health inventory for men (SHIM) score and vessels endothelial function and peripheral neuropathy were assessed by the brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), and vibration perception threshold (VPT) at 0, 3, 6, and 12 months after treatment.

Results: The mean age of 81 patients was 66.4?±?11.4 years old. Their prostate size was 30.2?±?22.1?ml.

Male LUTS parameters including IPSS, OABSS, and RU showed significant improvement from 1 to 12 months after tadalafil administration. Max and mean voiding flow was significantly increased at 6 months after tadalafil treatment.

The SHIM score showed significant improvement after 3 months. Whilst, the results of baPWV also showed significant improvement from 3 to 12 months. ABI was also significantly improved at 6 months. However, there was no change in the VPT at any time point.

Conclusions: Tadalafil is effective for both male LUTS and ED. It is also shown that tadalafil improves baPWV, which we can conclude that higher vessels elasticity has been obtained. This major finding of this study shows that tadalafil has the potency to improve vessels endothelial dysfunction in patients with BPH.     

Impact of metabolic status on the association of serum vitamin D with hypogonadism and lower urinary tract symptoms/benign prostatic hyperplasia

Objective: The objective of this study is to investigate the impact of metabolic status on associations of serum vitamin D with hypogonadism and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH).

Patients and methods: A total of 612 men underwent physical examination, biochemical/hormonal blood testing, and transrectal prostate ultrasound. Moreover, the subjects filled out standard questionnaires for identification and grading of LUTS and hypogonadism symptoms. Parameters were statistically compared with independent t-tests and correlation analyses.

Results: Vitamin D levels positively correlated with total testosterone (TT) but not with prostate volume or International Prostate Symptom Score (IPSS). Patients with metabolic syndrome had significantly lower vitamin D levels, which were not correlated with TT, prostate volume, or IPSS. However, vitamin D was positively correlated with TT, and negatively correlated with prostate volume and quality-of-life IPSS in subjects without metabolic syndrome.

Conclusion: The clinical usefulness of vitamin D for treatment of hypogonadism or LUTS/BPH varies according to metabolic status.     

Are urge incontinence and aging risk factors of erectile dysfunction in patients with male lower urinary tract symptoms?

Introduction: Several studies have indicated that erectile dysfunction (ED) patients also suffer from lower urinary tract symptoms (LUTS). We investigated a group of men with LUTS and assessed their sexual function with the aim of being able to predict ED risk factors and introduce ED treatments earlier for this patient group.

Methods: International Prostate Symptom Score (IPSS), Overactive Bladder Symptoms Score (OABSS) and Sexual Health Inventory for Men (SHIM) score were obtained from 236 men with LUTS at their first out-patients visit. Clinical parameters such as body mass index, prostate volume, residual urine volume and prostate specific antigen were also evaluated. The relationship between the SHIM score and other clinical data was analyzed.

Results: According to the SHIM score, ED in men with LUTS was severe 15%, moderate 19%, moderate to mild 28%, mild 17%, normal 7% and data was incomplete in 14%. Based on the results of a multivariate analysis, aging (p?p?=?0.024) were significantly correlated to severe and moderate ED. Furthermore, among OAB symptoms score items, urge urinary incontinence was a risk factor for severe and moderate ED (p?=?0.005).

Conclusion: Aging and OAB (notably urinary urge incontinence) are risk factors for severe and moderate ED in men with LUTS.     

描述译学的语言学模式

始于20世纪70年代的描述翻译学,因其具有理论和应用双重属性,有助于翻译理论研究和实践研究之间的沟通.而系统功能语言学,作为一种基于人类学、社会学、符号学的现代语言学理论,与描述翻译学具有相通的语言观、系统观和功能观.由此,系统功能语言学的系统理论、功能理论、语境理论,能够为描述翻译学提供一种更为细致、有效的研究途径.     

农村集体公益性建设用地的价值诉求与认知分析

农村集体公益性建设用地对农村公共设施的完善及农民生活水平的提高具有无可代替的作用,然现行规范对其规定甚少,集体公益性建设用地本身构造不明、价值不清造成适用模糊的困境。应明确农村集体公益性建设用地以维护集体成员利益为核心,以土地资源优化利用为重点,在具体设定上暗含公私力量的平衡。农村集体公益性建设用地使用权的主体实际上是以农民集体为核心的多元混合主体,因自身的公益属性,致使部分权能受限,应以合目的性与合规划性对其流转进行限制。