Introduction: In 2005, the International Committee of Medical Journal Editors (ICMJE) proposed that all submitted trials in all 11 member journals must be prospectively registered in order to be considered for publication. Registering drug trials was meant to reduce the likelihood of selective reporting. The aim was to determine the proportion of antipsychotic and antidepressant trials that were registered.
Methods: We searched in Pubmed for all randomized controlled trials of any antidepressant or antipsychotic published between July and December 2014. The primary objective was to determine the proportion of trials that were registered. Secondary objectives included comparing the reporting of methodological details and positive study findings between registered and unregistered trials.
Results: Of the 67 studies identified, 58% were registered. 75% of the antipsychotic trials and 51% of the antidepressant trials were registered, respectively. Registered trials were more likely to report important methodological details associated with risk of bias in RCTs. There was no significant difference in trials reporting positive outcomes for the study intervention between registered and unregistered trials.
Conclusion: Approximately 60% of published antidepressant and antipsychotic drug trials during July to December 2014 were registered. Unregistered trials were less likely to report important methodological details. 相似文献
ABSTRACTAdapting to a ‘green’ agenda requires active engagement of all relevant stakeholders such as societies, national, international and multinational corporations. Within organizations, leaders need to create a conducive organizational culture and identity to inculcate prosocial behaviours for becoming environmentally sensitive and responsible among employees through environmental citizenship. It can be argued that environmental citizenship among employees can enhance an organization’s environmental performance and impacts. Linking the notions and theories of social identity and environmental citizenship, this exploratory study examines the perceptions, attitudes and values of managers on engaging employees in green involvement. We also explore the organizational factors that were implemented across the workplace and its underpinning sustainable strategies for green engagement with an overarching research question: How can organizations promote green behaviour and identity among employees and engage them in meeting green targets for organizations? We employed a qualitative method by designing a focus group study. Our findings help us explore factors for promoting a social identity and environmental citizenship in business organizations and to understand speci?c methods that motivate green behaviours among employees, so that a culture and identity of being green becomes prominent and extends to the homes and wider society of employees. 相似文献