Physiologically Based Pharmacokinetic Models in Developmental Toxicology

The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid volumes and in the weight of the embryo/fetus and its developing organs. Physiologically-based models of pregnancy are capable of taking these temporal changes into account. Several such models have been developed. They vary in their characteristics, depending on the chemical under consideration and the period of gestation of concern to the developers of the models. Several physiologically-based models of gestation are outlined, and an example is given of the application of a physiologically-based model of gestation to predict dose to the rat and mouse fetus.     

《史记》感生神话与司马迁表现艺术

《史记》记载了商、周、秦始祖和汉高祖的感生神话,其中商、周、秦的感生神话都以经典为依据,但都简略;而刘邦的感生神话则详细、系统,与他的史学思想相悖。通过深入研究发现,从汉高祖到汉武帝经历了历史神话化的过程,形成了君权神授的理论。司马迁的《史记》完成了神话历史化,但又在其中设下了微言大义。后世不察,以此为书写历史著作的模范。     

Young Mothers and the Care System: Contextualizing Risk and Vulnerability

Although the UK has the highest levels of teenage pregnancyin Western Europe, and while adolescent mothering has receivedconsiderable recent attention from researchers, there is a paucityof research literature about the particular experiences of youngwomen who become mothers in or following local authority care.Findings from our empirical study reveal the significance ofrisk and vulnerability faced by a group of fifty-five youngmothers following their exit from care. This paper exploresthe impact of risk and vulnerability and also highlights thatalthough pregnancy may not be a planned activity, young womendemonstrate choice and rationality in their decision to becomemothers.     

少年跳高运动员力量训练的科学方法

针对少年跳高运动员的身体特点,通过对跳高技术动作的分析和参与跳高运动的肌群的分析,提出辅助训练、一般支撑力量练习、专项支撑力量练习等方法相结合的科学训练方法,并提出少年跳高运动员力量训练中需要注意的问题。     

Birth environments for women with complex pregnancies: A mixed-methods systematic review

BackgroundBirth environments can help support women through labour and birth. Home-like rooms which encourage active birthing are embraced in midwifery-led settings. However, this is often not reflected in obstetric settings for women with more complex pregnancies.AimTo investigate the impact of the birth environment for women with complex pregnancies.MethodsThis was a mixed-methods systematic review, incorporating qualitative and quantitative research. A literature search was implemented across three databases (Medline, CINAHL, Embase) from the year 2000 to June 2021. Studies were eligible if they were based in an Organisation for Economic Cooperation and Development country and reported on birth environments for women with complex pregnancies. Papers were screened and quality appraised by two researchers independently.Findings30,345 records were returned, with 15 articles meeting inclusion criteria. Studies were based in Australia, the UK, and the USA. Participants included women and health professionals. Five main themes arose: Quality of care and experience; Supportive spaces for women; Supportive spaces for midwives; Control of the space; Design issues.DiscussionWomen and midwives found the birth environment important in supporting, or failing to support, a positive birth experience. Obstetric environments are complex spaces requiring balance between space for women to mobilise and access birthing aids, with the need for medical teams to have easy access to the woman and equipment in emergencies.ConclusionFurther research is needed investigating different users’ needs from the environment and how safety features can be balanced with comfort to provide high-quality care and positive experiences for women.     

The impacts of the COVID-19 pandemic on birth satisfaction in a prospective cohort of 2,341 U.S. women

ProblemBirth satisfaction is an important health outcome that is related to postpartum mood, infant caretaking, and future pregnancy intention.BackgroundThe COVID-19 pandemic profoundly affected antenatal care and intrapartum practices that may reduce birth satisfaction.AimTo investigate the extent to which pandemic-related factors predicted lower birth satisfaction.Methods2341 women who were recruited prenatally in April–May 2020 and reported a live birth between April–October 2020 were included in the current analysis. Hierarchical linear regression to predict birth satisfaction from well-established predictors of birth satisfaction (step 1) and from pandemic-related factors (step 2) was conducted. Additionally, the indirect associations of pandemic-related stress with birth satisfaction were investigated.FindingsThe first step of the regression explained 35% of variance in birth satisfaction. In the second step, pandemic-related factors explained an additional 3% of variance in birth satisfaction. Maternal stress about feeling unprepared for birth due to the pandemic and restrictions on companions during birth independently predicted lower birth satisfaction beyond the non-pandemic variables. Pandemic-related unpreparedness stress was associated with more medicalized birth and greater incongruence with birth preference, thus also indirectly influencing birth satisfaction through a mediation process.DiscussionWell-established contributors to birth satisfaction remained potent during the pandemic. In addition, maternal stress and restriction on accompaniment to birth were associated with a small but significant reduction in birth satisfaction.ConclusionStudy findings suggest that helping women set flexible and reasonable expectations for birth and allowing at least one intrapartum support person can improve birth satisfaction.     

Repronormativity in cisgender men's reasons why they would not use womb transplant technology to become pregnant

Much reproductive scholarship presumes that cisgender men do not wish to become pregnant. And within scholarly discussions on womb transplant technology in particular, cis men's desires to be pregnant are constructed as ‘insubstantial’, and cis men are positioned as neither desiring nor requiring womb transplant technology. Repronormativity, including the assumption that pregnancy and gestational desire are antithetical to cis masculinity/manhood, underpins both bodies of work. As part of a study that sought to visibilise, and analyse narratives of, cis men's desires to be pregnant and/or gestational parents, six cis men were asked whether they would use womb transplant technology to enable their pregnancy if womb transplant technology included men as recipients. The majority of participants said they would not do so, giving different reasons. Using a narrative-discursive approach to analyse their responses, I argue that their varied responses disrupt and re-circulate normative discourses on sex/gender, pregnancy, parenthood, and (assisted) reproduction. Ultimately, their varied reasons trouble the normative assumption that cis men do not want to be pregnant and would not take up the opportunity to do so, because they are men.