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排序方式: 共有389条查询结果,搜索用时 15 毫秒
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Safa Ali Ahmed Amar Recep Eryilmaz Halit Demir Serdar Aykan Canan Demir 《The aging male》2019,22(3):198-206
In this study, the antioxidant enzyme activities such as (SOD, GSH, and CAT) and malondialdehyde (MDA) level which is the end product of lipid peroxidation, were determined from the serum samples taken from patients diagnosed with prostate cancer Van Yuzuncu Y?l University Medical Faculty of Educational Research and Training Hospital and ?stanbul Bagcilar Education Research Hospital. The SOD, GSH, and CAT activity of patient groups was found significantly lower than the healthy control group in patients with prostate cancer (p?.05). Serum MDA level is found significantly high when compared to control groups. MDA levels increased in patients that suffer prostate cancer disorder. Whereas, firstly antioxidant enzymes activity of SOD, GSH and CAT have been decreased in control groups. Thus, we concluded that the cause of development of prostate cancer may be the result of an imbalance between the antioxidants and oxidative stress. As a result, SOD, CAT, GSH, and MDA may play an important role in the etiopathogenesis of prostate cancer. 相似文献
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采用蛋白组学方法,利用4例中国肺癌患者的切除肺癌组织测定了磷癌(SQCLC)的蛋白表达 从双向电泳(2-DEgel)切下53个点,49个蛋白与数据库搜索结果吻合。在鉴定的24个蛋白中,17个蛋白有报道是与肺癌相关的蛋白其7个蛋白与人类其它癌症相关。所建立的蛋白组学方法能够用于建立一种基于组织的化验方法,发现肺癌患者组织中表达的蛋白标记物以用于癌症的分子学诊断。 相似文献
4.
庞慧敏 《山西大学学报(哲学社会科学版)》2022,(1):74-83
文章通过对国内"医享网"癌症社区"肺癌圈"中33篇精华帖的叙事分析,探究其中生命故事的主体对自我身份的建构路径及其对生命价值的意义探寻,并尝试性地提出一些反思。研究发现,在自述和他述生命故事中,叙事者在信息寻求过程中改善自我印象,并运用"写作疗法""阅读疗法"和叙事隐喻理解疾病,帮助患者重塑自身角色。通过社群互动,患者形塑了对自身的身份认同,并形成了集体层面的生命价值观。从本研究的结论看,疾病叙事是癌症网络社区患者建构个体身份、形成身份认同的重要途径,叙事或可成为未来增进社会对癌症乃至其他疾病的理解、推进治疗与康复的可行之路。 相似文献
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《Risk analysis》2018,38(9):1962-1971
Given the recent increase in dust‐induced lung disease among U.S. coal miners and the respiratory hazards encountered across the U.S. mining industry, it is important to enhance an understanding of lung disease trends and the organizational contexts that precede these events. In addition to exploring overall trends reported to the Mine Safety and Health Administration (MSHA), the current study uses MSHA's enforcement database to examine whether or not compliance with health regulations resulted in fewer mine‐level counts of these diseases over time. The findings suggest that interstitial lung diseases were more prevalent in coal mines compared to other mining commodities, in Appalachian coal mines compared to the rest of the United States, and in underground compared to surface coal mines. Mines that followed a relevant subset of MSHA's health regulations were less likely to report a lung disease over time. The findings are discussed from a lung disease prevention strategy perspective. 相似文献
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The Colorectal Cancer Control Program (CRCCP) provided funding to 29 grantees to increase colorectal cancer screening. We describe the screening promotion costs of CRCCP grantees to evaluate the extent to which the program model resulted in the use of funding to support interventions recommended by the Guide to Community Preventive Services (Community Guide). We analyzed expenditures for screening promotion for the first three years of the CRCCP to assess cost per promotion strategy, and estimated the cost per person screened at the state level based on various projected increases in screening rates. All grantees engaged in small media activities and more than 90% used either client reminders, provider assessment and feedback, or patient navigation. Based on all expenditures, projected cost per eligible person screened for a 1%, 5%, and 10% increase in state-level screening proportions are $172, $34, and $17, respectively. CRCCP grantees expended the majority of their funding on Community Guide recommended screening promotion strategies but about a third was spent on other interventions. Based on this finding, future CRC programs should be provided with targeted education and information on evidence-based strategies, rather than broad based recommendations, to ensure that program funds are expended mainly on evidence-based interventions. 相似文献
7.
目的:探讨血清同型半胱氨酸在肺癌患者中的变化及临床意义。方法检测82例住院治疗肺癌患者和79例健康体检者空腹血清同型半胱氨酸水平。结果分析得出肺癌组的血清Hcy含量显著高于健康对照组,差异有统计学意义(P<0.01)。Ⅰ~Ⅳ期肺癌的患者血清Hcy含量均显著高于健康组(P<0.01)。结论血清Hcy可做为肺癌的病情诊断、疗效预后的辅助指标。 相似文献
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Marjolein J. E. Greuter Xiang‐Ming Xu Jie‐Bin Lew Evelien Dekker Ernst J. Kuipers Karen Canfell Gerrit A. Meijer Veerle M. H. Coupé 《Risk analysis》2014,34(5):889-910
Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC. 相似文献
10.
《Journal of women & aging》2013,25(1):57-76
A chronic, progressive, and potentially debilitating condition, osteoporosis has a multitude of currently untapped implications for effective social work practice. A working knowledge of the medical framework of the disease process itself is a prerequisite to informed practice. This article presents such information, along with the psychological and social components, in order to provide the social worker with the comprehensive biopsyehosaial knowledge base necessary for effective practice with the osteoporotic woman and her family. 相似文献