Two Statistics for Unconditional Exact Tests in Matched-Pairs Design

Abstract

In a recent article Hsueh et al. (Hsueh, H.-M., Liu, J.-P., Chen, J. J. (2001 Hsueh, H.-M., Liu, J.-P. and Chen, J. J. 2001. Unconditional exact tests for equivalence or noninferiority for paired binary endpoints. Biometrics, 57: 478–483. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Unconditional exact tests for equivalence or noninferiority for paired binary endpoints. Biometrics 57:478–483.) considered unconditional exact tests for paired binary endpoints. They suggested two statistics one of which is based on the restricted maximum-likelihood estimator. Properties of these statistics and the related tests are treated in this article.     

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Inference of non-centrality parameter of a truncated non-central chi-squared distribution

Non-central chi-squared distribution plays a vital role in statistical testing procedures. Estimation of the non-centrality parameter provides valuable information for the power calculation of the associated test. We are interested in the statistical inference property of the non-centrality parameter estimate based on one observation (usually a summary statistic) from a truncated chi-squared distribution. This work is motivated by the application of the flexible two-stage design in case–control studies, where the sample size needed for the second stage of a two-stage study can be determined adaptively by the results of the first stage. We first study the moment estimate for the truncated distribution and prove its existence, uniqueness, and inadmissibility and convergence properties. We then define a new class of estimates that includes the moment estimate as a special case. Among this class of estimates, we recommend to use one member that outperforms the moment estimate in a wide range of scenarios. We also present two methods for constructing confidence intervals. Simulation studies are conducted to evaluate the performance of the proposed point and interval estimates.     

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C++语言的高效性、共享性与重用性

分析了C 语言利用指针、引用、内联函数与友元提高程序运行效率的机制,利用静态数据成员及成员函数节省内存开销共享的机制,以及利用继承、模板与多态实现无限制重用已有程序代码的机制,指出C 语言更适合编写大型应用程序.     

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