基于资源流网络优化的Max-npv项目调度

活动拖期通过资源流网络的传递会严重影响项目的净现值收益。针对该问题，本文首先在确定性环境下采用模拟退火算法(SA)构建了Max-NPV(Maximize the Net Present Value)非鲁棒性基准调度计划，然后考虑到活动工期的不确定性，设计了MEPC(Minimize Expected Penalty Cost)资源流网络优化算法，通过鲁棒性资源分配实现净现值期望惩罚成本最小化。大规模仿真对比实验结果表明，在活动工期低、中、高三种不确定性程度下，相对于采用随机资源分配算法(SA+RRAS)构建的非鲁棒性调度计划，SA+MEPC算法构建的鲁棒性调度计划在项目净现值实际收益、调度计划的“解”鲁棒性和“质”鲁棒性三个方面都取得了更好的结果，并且应对活动拖期风险的能力也更强。     

Development of a novel machine learning-based weighted modeling approach to incorporate Salmonella enterica heterogeneity on a genetic scale in a dose–response modeling framework

Estimating microbial dose–response is an important aspect of a food safety risk assessment. In recent years, there has been considerable interest to advance these models with potential incorporation of gene expression data. The aim of this study was to develop a novel machine learning model that considers the weights of expression of Salmonella genes that could be associated with illness, given exposure, in hosts. Here, an elastic net-based weighted Poisson regression method was proposed to identify Salmonella enterica genes that could be significantly associated with the illness response, irrespective of serovar. The best-fit elastic net model was obtained by 10-fold cross-validation. The best-fit elastic net model identified 33 gene expression–dose interaction terms that added to the predictability of the model. Of these, nine genes associated with Salmonella metabolism and virulence were found to be significant by the best-fit Poisson regression model (p < 0.05). This method could improve or redefine dose–response relationships for illness from relative proportions of significant genes from a microbial genetic dataset, which would help in refining endpoint and risk estimations.