An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.     

Generalized Estimating Equations for Symmetric Distributions Observed with Admixture

A semiparametric two-component mixture model is considered, in which the distribution of one (primary) component is unknown and assumed symmetric. The distribution of the other component (admixture) is known. Generalized estimating equations are constructed for the estimation of the mixture proportion and the location parameter of the primary component. Asymptotic normality of the estimates is demonstrated and the lower bound for the asymptotic covariance matrix is obtained. An adaptive estimation technique is proposed to obtain the estimates with nearly optimal asymptotic variances.     

On prediction from the location-scale model with equi correlated response

The location-scale model with equi-correlated responses is discussed. The structure of the location-scale model is utilised to genera-te the prediction distribution of a future response and that of a set of future responses. The method avoids the integration procedures usually involved in derivation of prediction distributions and yields results same as those obtained by the Bayes method with the vague prior distribution* Finally the re-suits have been specialised to cover the case of the normal intra-class model.     

Nonparametric prediction analysis for binary data

A nonparametric inference algorithm developed by Davis and Geman (1983) is extended problem. The algorithm and applied to a medical prediction employs an estimation procedure for acquiring pairwise statistics among variables of a binary data set, allows for the data-driven creation of interaction terms among the variables, and employs a decision rule which asymptotically gives the minimum expected error. The inference procedure was designed for large data sets but has been extended via the method of cross-validation to encompass smaller data sets.     

Discrete adaptive design in attribute life testing

Properties of a discrete adaptive design in attribute life testing situation are studied. It is shown that the design is strongly consistent and asymptotically normal. Some examples are discussed to show that the design could be used in a wide range of ields, Finally, we give some simulation results to compare the discrete adaptive desigin with some continuous optimal designs.     

Time Series Modeling of Degradation Due to Outdoor Weathering

Environmental variables have an important effect on the reliability of many products such as coatings and polymeric composites. Long-term prediction of the performance or service life of such products must take into account the probabilistic/stochastic nature of the outdoor weather. In this article, we propose a time series modeling procedure to model the time series data of daily accumulated degradation. Daily accumulated degradation is the total amount of degradation accrued within one day and can be obtained by using a degradation rate model for the product and the weather data. The fitted model of the time series can then be used to estimate the future distribution of cumulative degradation over a period of time, and to compute reliability measures such as the probability of failure. The modeling technique and estimation method are illustrated using the degradation of a solar reflector material. We also provide a method to construct approximate confidence intervals for the probability of failure.     

Bayesian prediction bounds for the pareto lifetime model

Suppose that the length of time in years for which a business operates until failure has a Pareto distribution. Let x₁ ≤ x₂ x₃ ≤…≤z_k denote the survival lifetimes of the first k of a random sample of n businesses. Bayesian predictions are to be made on the ordered failure times of t h e remaining (n-k) businesses, using the conditional probability density function. Examples are given to illustrate our results.     

Large sample estimation and prediction for explosive growth curve models

Asymptotic distributions of maximum likelihood estimators for the parameters in explosive growth curve models are derived. Limit distributions of prediction errors when the parameters are estimated are also obtained. The growth curve models are viewed as multivariate time-series models, and the usual time-series methods are used for prediction. Estimation constrained by a hypothesis of homogeneity of growth rates is also considered.     

Bayes prediction of number of failures in weibull samples

This work is concerned with the Bayesian prediction problem of the number of components which will fail in a future time interval, when the failure times are Weibull distributed. Both the 1-sample and the 2-sample prediction problems are dealed with, and some choices of the prior densities on the distribution parameters are discussed which are relatively easy to work with and allow different degrees of knowledge on the failure mechanism to be incorporated in the predictive procedure. Useful relations between the predictive distribution on the number of future failures and the predictive distribution on the future failure times are derived. Numerical examples are also given.