Estimating the association parameter for copula models under dependent censoring

Summary. Many biomedical studies involve the analysis of multiple events. The dependence between the times to these end points is often of scientific interest. We investigate a situation when one end point is subject to censoring by the other. The model assumptions of Day and co-workers and Fine and co-workers are extended to more general structures where the level of association may vary with time. Two types of estimating function are proposed. Asymptotic properties of the proposed estimators are derived. Their finite sample performance is studied via simulations. The inference procedures are applied to two real data sets for illustration.     

Evaluating Risk Communications: Completing and Correcting Mental Models of Hazardous Processes, Part II

We propose a decision-analytic framework, called the mental models approach , for evaluating the impact of risk communications. It employs multiple evaluation methods, including think-aloud protocol analysis, problem solving, and a true-false test that allows respondents to express uncertainty about their answers. The approach is illustrated in empirical comparisons of three brochures about indoor radon.     

Multistage Models of Carcinogenesis: An Approximation for the Size and Number Distribution of Late-Stage Clones

Multistage models have become the basic paradigm for modeling carcinogenesis. One model, the two-stage model of carcinogenesis, is now routinely used in the analysis of cancer risks from exposure to environmental chemicals. In its most general form, this model has two states, an initiated state and a neoplastic state, which allow for growth of cells via a simple linear birth-death process. In all analyses done with this model, researchers have assumed that tumor incidence is equivalent to the formation of a single neoplastic cell and the growth kinetics in the neoplastic state have been ignored. Some researchers have discussed the impact of this assumption on their analyses, but no formal methods were available for a more rigorous application of the birth-death process. In this paper, an approximation is introduced which allows for the application of growth kinetics in the neoplastic state. The adequacy of the approximation against simulated data is evaluated and methods are developed for implementing the approximation using data on the number and size of neoplastic clones.     

Non parametric mixture priors based on an exponential random scheme

We propose a general procedure for constructing nonparametric priors for Bayesian inference. Under very general assumptions, the proposed prior selects absolutely continuous distribution functions, hence it can be useful with continuous data. We use the notion ofFeller-type approximation, with a random scheme based on the natural exponential family, in order to construct a large class of distribution functions. We show how one can assign a probability to such a class and discuss the main properties of the proposed prior, namedFeller prior. Feller priors are related to mixture models with unknown number of components or, more generally, to mixtures with unknown weight distribution. Two illustrations relative to the estimation of a density and of a mixing distribution are carried out with respect to well known data-set in order to evaluate the performance of our procedure. Computations are performed using a modified version of an MCMC algorithm which is briefly described.     

EXPONENTIAL DISPERSION MODELS AND THE GAUSS-NEWTON ALGORITHM

It is known that the Fisher scoring iteration for generalized linear models has the same form as the Gauss-Newton algorithm for normal regression. This note shows that exponential dispersion models are the most general families to preserve this form for the scoring iteration. Therefore exponential dispersion models are the most general extension of generalized linear models for which the analogy with normal regression is preserved. The multinomial distribution is used as an example.     

An iterative Monte Carlo method for nonconjugate Bayesian analysis

The Gibbs sampler has been proposed as a general method for Bayesian calculation in Gelfand and Smith (1990). However, the predominance of experience to date resides in applications assuming conjugacy where implementation is reasonably straightforward. This paper describes a tailored approximate rejection method approach for implementation of the Gibbs sampler when nonconjugate structure is present. Several challenging applications are presented for illustration.     

信息服务模式研究

信息职务是横跨信息管理领域、产业经济领域及信息化、全球化进程中的重要研究课题。本文以信息服务的基本要素分析为基础，运用模式方法，探讨了旨在描述信息服务各要素间基本关系的基本模式、信息服务在实践中某个或某几个要素的作用发生变化而导致的生成模式以及由网络技术引发的网络信息服务模式，并对信息服务模式的发展机制进行了初步分析。     

H-likelihood: problems and solutions

In recent issues of this journal it has been asserted in two papers that the use of h-likelihood is wrong, in the sense of giving unsatisfactory estimates of some parameters for binary data (Kuk and Cheng, 1999; Waddington and Thompson, 2004) or theoretically unsound (Kuk and Cheng, 1999). We wish to refute both these assertions.