Least squares estimation of varying‐coefficient hazard regression with application to breast cancer dose‐intensity data

To enhance modeling flexibility, the authors propose a nonparametric hazard regression model, for which the ordinary and weighted least squares estimation and inference procedures are studied. The proposed model does not assume any parametric specifications on the covariate effects, which is suitable for exploring the nonlinear interactions between covariates, time and some exposure variable. The authors propose the local ordinary and weighted least squares estimators for the varying‐coefficient functions and establish the corresponding asymptotic normality properties. Simulation studies are conducted to empirically examine the finite‐sample performance of the new methods, and a real data example from a recent breast cancer study is used as an illustration. The Canadian Journal of Statistics 37: 659–674; 2009 © 2009 Statistical Society of Canada     

Sums of powers of binomial coefficients

An asymptotic series for sums of powers of binomial coefficients is derived, the general term being defined and usable with a computer symbolic language. Sums of squares of coefficients in the symmetric case are shown to have a link with classical moment problems, but this property breaks down for cubes and higher powers. Problems of remainders for the asymptotic series are mentioned. Using the reflection formula for I'(.), a continuous form for a binomial function is set up, and this becomes oscillatory outstde the usual range. A new contmued fraction emerges for the logarithm of an adjusted sum of binomial squares. The note is a contribution to the problem of the interpretation of asymptotic series and processes for their convergence acceleration.     

Asymptotic expaxsioxs for the joint distribution of cirrelated hotellings t2 statlstics under normality

Let T² _i=z′_iS^?1z_i, i==,…k be correlated Hotelling's T² statistics under normality. where z=(z′_i,…,z′_k)′ and nS are independently distributed as N_kp((O,ρ?∑) and Wishart distribution W_p(∑, n), respectively. The purpose of this paper is to study the distribution function F(x₁,…,x_k) of (T² _i,…,T² _k) when n is large. First we derive an asymptotic expansion of the characteristic function of (T² _i,…,T² _k) up to the order n^?2. Next we give asymptotic expansions for (T² _i,…,T² _k) in two cases (i)ρ=I_k and (ii) k=2 by inverting the expanded characteristic function up to the orders n^?2 and n^?1, respectively. Our results can be applied to the distribution function of max (T² _i,…,T² _k) as a special case.     

Large sample bias of maximum likeihood estimates from a series of sparse ixj tables

For a large series of IxJ tables, each containing two observations, the bias of the maximum likelihood estimates of log linear partial association parameters is shown to be equal to the parameters, regardless of the size of I and J. The partial association considered is that between row and column variables; the three way interactions are assumed to be O. This is a generalization of Andersen's results (1973a, 1973b) for a series of 2x2 tables.     

Sequential estimation problems for negative exponential populations

The literature on sequential estimation problems for negative exponential populations has been reviewed here, We attempt to bring in all the published and unpublished materials known to us in a fairly coherent fashion. Both the concepts and theoretical findings are discussed.     

Asymptotic relative efficiency of wald tests in measurement error models

In this paper, asymptotic relative efficiency (ARE) of Wald tests for the Tweedie class of models with log-linear mean, is considered when the aux¬iliary variable is measured with error. Wald test statistics based on the naive maximum likelihood estimator and on a consistent estimator which is obtained by using Nakarnura's (1990) corrected score function approach are defined. As shown analytically, the Wald statistics based on the naive and corrected score function estimators are asymptotically equivalents in terms of ARE. On the other hand, the asymptotic relative efficiency of the naive and corrected Wald statistic with respect to the Wald statistic based on the true covariate equals to the square of the correlation between the unobserved and the observed co-variate. A small scale numerical Monte Carlo study and an example illustrate the small sample size situation.     

Inference in Semi‐Parametric Dynamic Models for Repeated Count Data

This paper deals with a longitudinal semi‐parametric regression model in a generalised linear model setup for repeated count data collected from a large number of independent individuals. To accommodate the longitudinal correlations, we consider a dynamic model for repeated counts which has decaying auto‐correlations as the time lag increases between the repeated responses. The semi‐parametric regression function involved in the model contains a specified regression function in some suitable time‐dependent covariates and a non‐parametric function in some other time‐dependent covariates. As far as the inference is concerned, because the non‐parametric function is of secondary interest, we estimate this function consistently using the independence assumption‐based well‐known quasi‐likelihood approach. Next, the proposed longitudinal correlation structure and the estimate of the non‐parametric function are used to develop a semi‐parametric generalised quasi‐likelihood approach for consistent and efficient estimation of the regression effects in the parametric regression function. The finite sample performance of the proposed estimation approach is examined through an intensive simulation study based on both large and small samples. Both balanced and unbalanced cluster sizes are incorporated in the simulation study. The asymptotic performances of the estimators are given. The estimation methodology is illustrated by reanalysing the well‐known health care utilisation data consisting of counts of yearly visits to a physician by 180 individuals for four years and several important primary and secondary covariates.     

Testing Overdispersion in CUBE Models

A practical problem with large-scale survey data is the possible presence of overdispersion. It occurs when the data display more variability than is predicted by the variance–mean relationship. This article describes a probability distribution generated by a mixture of discrete random variables to capture uncertainty, feeling, and overdispersion. Specifically, several tests for detecting overdispersion will be implemented on the basis of the asymptotic theory for maximum likelihood estimators. We discuss the results of a simulation experiment concerning log-likelihood ratio, Wald, Score, and Profile tests. Finally, some real datasets are analyzed to illustrate the previous results.     

Testing Hypotheses in Nonparametric Models of Production

Data envelopment analysis (DEA) and free disposal hull (FDH) estimators are widely used to estimate efficiency of production. Practitioners use DEA estimators far more frequently than FDH estimators, implicitly assuming that production sets are convex. Moreover, use of the constant returns to scale (CRS) version of the DEA estimator requires an assumption of CRS. Although bootstrap methods have been developed for making inference about the efficiencies of individual units, until now no methods exist for making consistent inference about differences in mean efficiency across groups of producers or for testing hypotheses about model structure such as returns to scale or convexity of the production set. We use central limit theorem results from our previous work to develop additional theoretical results permitting consistent tests of model structure and provide Monte Carlo evidence on the performance of the tests in terms of size and power. In addition, the variable returns to scale version of the DEA estimator is proved to attain the faster convergence rate of the CRS-DEA estimator under CRS. Using a sample of U.S. commercial banks, we test and reject convexity of the production set, calling into question results from numerous banking studies that have imposed convexity assumptions. Supplementary materials for this article are available online.     

Conditional VAR and Expected Shortfall: A New Functional Approach

We estimate two well-known risk measures, the value-at-risk (VAR) and the expected shortfall, conditionally to a functional variable (i.e., a random variable valued in some semi(pseudo)-metric space). We use nonparametric kernel estimation for constructing estimators of these quantities, under general dependence conditions. Theoretical properties are stated whereas practical aspects are illustrated on simulated data: nonlinear functional and GARCH(1,1) models. Some ideas on bandwidth selection using bootstrap are introduced. Finally, an empirical example is given through data of the S&P 500 time series.