艾滋病疗法的评价及疗效的预测

根据美国艾滋病医疗实验机构ACTG提供的两组数据,利用二次拟合预测了持续使用这四种艾滋病疗法的效果,并对这些疗法做出了一定的评价。     

Bayesian robustness of the compound Poisson distribution under bidimensional prior: an application to the collective risk model

The distribution of the aggregate claims in one year plays an important role in Actuarial Statistics for computing, for example, insurance premiums when both the number and size of the claims must be implemented into the model. When the number of claims follows a Poisson distribution the aggregated distribution is called the compound Poisson distribution. In this article we assume that the claim size follows an exponential distribution and later we make an extensive study of this model by assuming a bidimensional prior distribution for the parameters of the Poisson and exponential distribution with marginal gamma. This study carries us to obtain expressions for net premiums, marginal and posterior distributions in terms of some well-known special functions used in statistics. Later, a Bayesian robustness study of this model is made. Bayesian robustness on bidimensional models was deeply treated in the 1990s, producing numerous results, but few applications dealing with this problem can be found in the literature.     

Posterior Analysis for Normalized Random Measures with Independent Increments

Abstract.  One of the main research areas in Bayesian Nonparametrics is the proposal and study of priors which generalize the Dirichlet process. In this paper, we provide a comprehensive Bayesian non-parametric analysis of random probabilities which are obtained by normalizing random measures with independent increments (NRMI). Special cases of these priors have already shown to be useful for statistical applications such as mixture models and species sampling problems. However, in order to fully exploit these priors, the derivation of the posterior distribution of NRMIs is crucial: here we achieve this goal and, indeed, provide explicit and tractable expressions suitable for practical implementation. The posterior distribution of an NRMI turns out to be a mixture with respect to the distribution of a specific latent variable. The analysis is completed by the derivation of the corresponding predictive distributions and by a thorough investigation of the marginal structure. These results allow to derive a generalized Blackwell–MacQueen sampling scheme, which is then adapted to cover also mixture models driven by general NRMIs.     

Bayesian partial likelihood approach for tied observations

The Bayesian analysis based on the partial likelihood for Cox's proportional hazards model is frequently used because of its simplicity. The Bayesian partial likelihood approach is often justified by showing that it approximates the full Bayesian posterior of the regression coefficients with a diffuse prior on the baseline hazard function. This, however, may not be appropriate when ties exist among uncensored observations. In that case, the full Bayesian and Bayesian partial likelihood posteriors can be much different. In this paper, we propose a new Bayesian partial likelihood approach for many tied observations and justify its use.     

On reliability estimation based on fuzzy lifetime data

Real lifetime data are never precise numbers but more or less non-precise, also called fuzzy. This kind of imprecision is connected with all measurement results of continuous variables, therefore also with time observations. Imprecision is different from errors and variability. Therefore estimation methods for reliability characteristics have to be adapted to the situation of fuzzy lifetimes in order to obtain realistic results.     

A comparison of nonparametric priors in hierarchical mixture modelling for AFT regression

We will pursue a Bayesian nonparametric approach in the hierarchical mixture modelling of lifetime data in two situations: density estimation, when the distribution is a mixture of parametric densities with a nonparametric mixing measure, and accelerated failure time (AFT) regression modelling, when the same type of mixture is used for the distribution of the error term. The Dirichlet process is a popular choice for the mixing measure, yielding a Dirichlet process mixture model for the error; as an alternative, we also allow the mixing measure to be equal to a normalized inverse-Gaussian prior, built from normalized inverse-Gaussian finite dimensional distributions, as recently proposed in the literature. Markov chain Monte Carlo techniques will be used to estimate the predictive distribution of the survival time, along with the posterior distribution of the regression parameters. A comparison between the two models will be carried out on the grounds of their predictive power and their ability to identify the number of components in a given mixture density.     

Bayesian credible intervals for response surface optima

In response surface methodology, one is usually interested in estimating the optimal conditions based on a small number of experimental runs which are designed to optimally sample the experimental space. Typically, regression models are constructed from the experimental data and interrogated in order to provide a point estimate of the independent variable settings predicted to optimize the response. Unfortunately, these point estimates are rarely accompanied with uncertainty intervals. Though classical frequentist confidence intervals can be constructed for unconstrained quadratic models, higher order, constrained or nonlinear models are often encountered in practice. Existing techniques for constructing uncertainty estimates in such situations have not been implemented widely, due in part to the need to set adjustable parameters or because of limited or difficult applicability to constrained or nonlinear problems. To address these limitations a Bayesian method of determining credible intervals for response surface optima was developed. The approach shows good coverage probabilities on two test problems, is straightforward to implement and is readily applicable to the kind of constrained and/or nonlinear problems that frequently appear in practice.     

R×C ecological inference: bounds, correlations, flexibility and transparency of assumptions

Summary.  Despite its potential pitfalls, ecological inference is an unavoidable part of some quantitative settings, including US voting rights litigation. In such applications, the analyst will typically encounter two-way tables with more than two rows and columns. Although several ecological inference methods are currently available for 2×2 tables, there are fewer options for analysing general R × C tables, and virtually none that model counts as opposed to fractions. We propose a count R × C method that respects the bounds deterministically, that allows for complex relationships between internal cell quantities, that is easily extensible and that results from transparent assumptions. We study the method via simulation, and then apply it to an example that is drawn from the state of Texas relevant to recent redistricting litigation there.     

Using Bayesian graphical models to model biases in observational studies and to combine multiple sources of data: application to low birth weight and water disinfection by-products

Summary.  Data in the social, behavioural and health sciences frequently come from observational studies instead of controlled experiments. In addition to random errors, observational data typically contain additional sources of uncertainty such as missing values, unmeasured confounders and selection biases. Also, the research question is often different from that which a particular source of data was designed to answer, and so not all relevant variables are measured. As a result, multiple sources of data are often necessary to identify the biases and to inform about different aspects of the research question. Bayesian graphical models provide a coherent way to connect a series of local submodels, based on different data sets, into a global unified analysis. We present a unified modelling framework that will account for multiple biases simultaneously and give more accurate parameter estimates than standard approaches. We illustrate our approach by analysing data from a study of water disinfection by-products and adverse birth outcomes in the UK.     

基于多变量动态模型的产出缺口估算

 本文运用多变量动态模型系统下的Beveridge-Nelson分解方法和贝叶斯Gibbs抽样估计,估算了1985年1季度至2008年2季度期间中国的产出缺口,并且与传统的单变量估计方法测算的结果在统计属性和对货币政策调节的预测效果方面进行了比较。实证结果表明,不同产出缺口的统计属性存在差别,并且只有基于多变量系统测算的产出缺口对货币政策具有显著预测效果。这说明多变量模型估计出的产出缺口更全面地考虑了经济产出与其他相关变量的互动效应,含有的信息更为丰富,从而对宏观政策调整具有更重要的参考价值。