An efficient sequential design of clinical trials

We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving of sample size compared to existing adaptive designs. A method is also proposed to obtain a reduced-bias estimator of treatment difference for the proposed design. The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials. Operating characteristics are evaluated and compared with other group sequential designs in empirical studies. An example is provided to illustrate the application of the method.     

Asymptotic normality of Huber–Dutter estimators in a linear model with AR(1) processes

The paper studies a linear regression model with first order autoregressive (AR(1)) processes. The Huber–Dutter (HD) estimators of unknown parameters are given, and the asymptotic normality of the HD estimators is investigated. An example is presented to illustrate the proposed method.     

基于季报数据的收入公告后漂移现象研究

利用收入指标对股票超额收益率进行解释构成了理解"定价异常"的重要方面。为此,基于盈余公告后漂移的理论分析框架,以上证A股2008年1季度至2011年4季度的相关数据为基础,利用标准化预期外收入估计量(SURE)和分类检验模型方法对中国股票市场公告期内股票价格的收入公告后漂移现象进行实证检验,研究发现:在盈余公告期内,预期外收入与股票超额收益率呈现出负相关或是不显著的关系,即中国股票市场的收入公告后漂移效应不显著。之后的稳健性分析也同样证实了负相关或是不显著关系的存在,而这种异常可能与中国股市的弱有效率相关。     

Asymptotically minimax non–parametric function estimation with positivity constraints I

The spatially inhomogeneous smoothness of the non-parametric density or regression-function to be estimated by non-parametric methods is often modelled by Besov- and Triebel-type smoothness constraints. For such problems, Donoho and Johnstone [D.L. Donoho and I.M. Johnstone, Minimax estimation via wavelet shrinkage. Ann. Stat. 26 (1998), pp. 879–921.], Delyon and Juditsky [B. Delyon and A. Juditsky, On minimax wavelet estimators, Appl. Comput. Harmon. Anal. 3 (1996), pp. 215–228.] studied minimax rates of convergence for wavelet estimators with thresholding, while Lepski et al. [O.V. Lepski, E. Mammen, and V.G. Spokoiny, Optimal spatial adaptation to inhomogeneous smoothness: an approach based on kernel estimators with variable bandwidth selectors, Ann. Stat. 25 (1997), pp. 929–947.] proposed a variable bandwidth selection for kernel estimators that achieved optimal rates over Besov classes. However, a second challenge in many real applications of non-parametric curve estimation is that the function must be positive. Here, we show how to construct estimators under positivity constraints that satisfy these constraints and also achieve minimax rates over the appropriate smoothness class.     

A note on Stein-type shrinkage estimator in partial linear models

In this paper, an exact sufficient condition for the dominance of the Stein-type shrinkage estimator over the usual unbiased estimator in a partial linear model is exhibited. Comparison result is then done under the balanced loss function. It is assumed that the vector of disturbances is typically distributed according to the law belonging to the sub-class of elliptically contoured models. It is also shown that the dominance condition is robust. Furthermore, a nonparametric estimation after estimation of the linear part is added for detecting the efficiency of the obtained results.     

Reliability estimation in stress–strength models: an MCMC approach

In this paper, we consider the estimation of the stress–strength parameter R=P(Y<X) when X and Y are independent and both are modified Weibull distributions with the common two shape parameters but different scale parameters. The Markov Chain Monte Carlo sampling method is used for posterior inference of the reliability of the stress–strength model. The maximum-likelihood estimator of R and its asymptotic distribution are obtained. Based on the asymptotic distribution, the confidence interval of R can be obtained using the delta method. We also propose a bootstrap confidence interval of R. The Bayesian estimators with balanced loss function, using informative and non-informative priors, are derived. Different methods and the corresponding confidence intervals are compared using Monte Carlo simulations.     

Strong approximation of empirical copula processes by Gaussian processes

In this paper, we provide the strong approximation of normalized empirical copula processes by a Gaussian process. In addition, we establish a strong approximation of the smoothed empirical copula processes and a law of iterated logarithm.     

A note on Pitman's measure of closeness with balanced loss function

In this note, we consider the problem of estimating an unknown parameter θ in the sense of the Pitman's measure of closeness (PMC) using the balanced loss function (BLF). We show that the PMC comparison of estimators under the BLF can be reduced to the PMC comparison under the usual absolute error loss. The Pitman-closest estimators of the location and scale parameters under BLF are also characterized. Illustrative examples are given to show the broad range applications of the obtained results.     

A more general methodology for fitting global cross-ratio models for discrete longitudinal responses

In this paper, we focus on repeated measurement problems, comprising an interesting research area in statistics. We study longitudinal data which arise when outcomes are observed repeatedly on each experimental subject at several points. We focus on a marginal approach for this type of data with lack of independence among the observations proposed by Dale [Global cross-ratio models for bivariate, discrete, ordered responses. Biometrics. 1986;42(4):909–917] for bivariate, discrete, ordered responses. We propose an alternative estimation based on divergence measures to the full likelihood method proposed in that paper. Finally, a wide simulation study and a data example that illustrates the new methodology is provided.