A COMPARISON OF THE IMPRECISE BETA CLASS, THE RANDOMIZED PLAY-THE-WINNER RULE AND THE TRIANGULAR TEST FOR CLINICAL TRIALS WITH BINARY RESPONSES

This paper develops clinical trial designs that compare two treatments with a binary outcome. The imprecise beta class (IBC), a class of beta probability distributions, is used in a robust Bayesian framework to calculate posterior upper and lower expectations for treatment success rates using accumulating data. The posterior expectation for the difference in success rates can be used to decide when there is sufficient evidence for randomized treatment allocation to cease. This design is formally related to the randomized play‐the‐winner (RPW) design, an adaptive allocation scheme where randomization probabilities are updated sequentially to favour the treatment with the higher observed success rate. A connection is also made between the IBC and the sequential clinical trial design based on the triangular test. Theoretical and simulation results are presented to show that the expected sample sizes on the truly inferior arm are lower using the IBC compared with either the triangular test or the RPW design, and that the IBC performs well against established criteria involving error rates and the expected number of treatment failures.     

Weak and strong laws of large numbers for coherent lower previsions

We prove weak and strong laws of large numbers for coherent lower previsions, where the lower prevision of a random variable is given a behavioural interpretation as a subject's supremum acceptable price for buying it. Our laws are a consequence of the rationality criterion of coherence, and they can be proven under assumptions that are surprisingly weak when compared to the standard formulation of the laws in more classical approaches to probability theory.     

ASYMPTOTIC PROPERTIES OF AN OPTIMAL ESTIMATING FUNCTION APPROACH TO THE ANALYSIS OF MARK RECAPTURE DATA

ABSTRACT

A drawback of non parametric estimators of the size of a closed population in the presence of heterogeneous capture probabilities has been their lack of analytic tractability. Here we show that the martingale estimating function/sample coverage approach to estimating the size of a closed population with heterogeneous capture probabilities is mathematically tractable and develop its large sample properties.     

Exact Linear Restrictions on Parameters in the Classical Linear Regression Model

We consider a simple sampling scheme where after each drawing there is a “replacement” whose magnitude is a fixed real number. This gives a unified approach to a family of discrete distributions that includes the hypergeometric, binomial, and Polya distributions as well as their multivariate versions.     

Improved Confidence Statements for the Binomial Parameter

In the computation of two-sided confidence intervals for the binomial parameter p (using the binomial mass function), it is known that such intervals achieve a confidence coefficient that in general is not equal to the confidence level 1 – α, say. In this article we present some general results on the confidence coefficient and tabulate them for selected pairs (α, n = number of trials). We treat only the nominal equal tail probability case because it is the most commonly taught and used.     

Application of box-cox transformations to discrimination for the two-class problem

The performance of Box-Cox power transformations in classification using Hinkley's (1975) method is studied. Misclassification probabilities before and after transformation are compared. It is found that the use of Box-Cox transformations can sometimes substantially reduce the error probabilities. Estimates of error probabilities are obtained and certain properties are derived. Examples for a number of distributions are given.     

Using Time Intervals Between Expected Events to Communicate Risk Magnitudes

Because members of the public have difficulty understanding risk presented in terms of odds ratios (e.g., 1 in 1000) and in comparing odds ratios from different hazards, we examined the use of time intervals between expected harmful events to communicate risk. Perceptions of the risk from a hypothetical instance of naturally-occurring, cancer-causing arsenic in drinking water supplies was examined with a sample of 705 homeowners. The risk was described as either 1 in 1000 or 1 in 100,000 and as present in a town of 2000 people or a city of 200,000 people. With these parameters, the time intervals ranged from 1 expected death in 3500 years (1 in 100,000 risk, small town) to 1 death every 4 months (1 in 1000 risk, city). The addition of time intervals to the odds ratios significantly decreased perceived threat and perceived need for action in the small town but did not affect response for the city. These framing effects were nearly as large as a 100-fold difference in actual risk. Instances when this communication approach may be useful are discussed.     

Combining Probability Distributions From Experts in Risk Analysis

This paper concerns the combination of experts' probability distributions in risk analysis, discussing a variety of combination methods and attempting to highlight the important conceptual and practical issues to be considered in designing a combination process in practice. The role of experts is important because their judgments can provide valuable information, particularly in view of the limited availability of hard data regarding many important uncertainties in risk analysis. Because uncertainties are represented in terms of probability distributions in probabilistic risk analysis (PRA), we consider expert information in terms of probability distributions. The motivation for the use of multiple experts is simply the desire to obtain as much information as possible. Combining experts' probability distributions summarizes the accumulated information for risk analysts and decision-makers. Procedures for combining probability distributions are often compartmentalized as mathematical aggregation methods or behavioral approaches, and we discuss both categories. However, an overall aggregation process could involve both mathematical and behavioral aspects, and no single process is best in all circumstances. An understanding of the pros and cons of different methods and the key issues to consider is valuable in the design of a combination process for a specific PRA. The output, a combined probability distribution, can ideally be viewed as representing a summary of the current state of expert opinion regarding the uncertainty of interest.     

A Simple Variance Estimator for Unequal Probability Sampling without Replacement

Survey sampling textbooks often refer to the Sen–Yates–Grundy variance estimator for use with without-replacement unequal probability designs. This estimator is rarely implemented because of the complexity of determining joint inclusion probabilities. In practice, the variance is usually estimated by simpler variance estimators such as the Hansen–Hurwitz with replacement variance estimator; which often leads to overestimation of the variance for large sampling fractions that are common in business surveys. We will consider an alternative estimator: the Hájek (1964 Hájek J 1981 Sampling from a Finite Population New York: Marcel Dekker  [Google Scholar]) variance estimator that depends on the first-order inclusion probabilities only and is usually more accurate than the Hansen–Hurwitz estimator. We review this estimator and show its practical value. We propose a simple alternative expression; which is as simple as the Hansen–Hurwitz estimator. We also show how the Hájek estimator can be easily implemented with standard statistical packages.     

Quantitative refinements for comparisons of institutional performance

In the context of the data and issues discussed by Goldstein and Spiegelhalter, we suggest refinements which can be used by decision makers when confronted with ranking problems associated with 'league tables'. Two ranking criteria are defined and their performance illustrated for one of the studies reported by Goldstein and Spiegelhalter.