Relationships of optimality for individual factors of a design

The optimality of two-factor experimental designs is studied in the dual senses of estimating contrasts in the parameters for each of the factors. The outline of comparison employed allows one to judge the performance of different designs for estimating contrasts of one set of parameters directly with the performance of the complementary set without going through a common intermediary step of considering all the parameters. The results hold for a wide class of optimality criteria (not merely D-, A- and E-optimality), which must satisfy a functional equation obtained in connection with our method. Also we investigate the optimality of row–column designs which satisfy an ‘adjusted orthogonality’ condition. Our point of departure is the paper by Shah, Raghavarao and Khatri (1976) and that of Mitchell and John (1977).     

Generalized Youden designs: construction and tables

Generalized Youden Designs are generalizations of the class of two-way balanced block designs which include Latin squares and Youden squares. They are used for the same purposes and in the same way that these classical designs are used, and satisfy most of the common criteria of design optimality.We explicitly display or give detailed instructions for constructing all these designs within a practical range: when υ, the number of treatments, is ?25; and b₁ and b₂, the dimensions of the design array, are each ?50.     

Fast and Accurate Inference for the Smoothing Parameter in Semiparametric Models

A fast and accurate method of confidence interval construction for the smoothing parameter in penalised spline and partially linear models is proposed. The method is akin to a parametric percentile bootstrap where Monte Carlo simulation is replaced by saddlepoint approximation, and can therefore be viewed as an approximate bootstrap. It is applicable in a quite general setting, requiring only that the underlying estimator be the root of an estimating equation that is a quadratic form in normal random variables. This is the case under a variety of optimality criteria such as those commonly denoted by maximum likelihood (ML), restricted ML (REML), generalized cross validation (GCV) and Akaike's information criteria (AIC). Simulation studies reveal that under the ML and REML criteria, the method delivers a near‐exact performance with computational speeds that are an order of magnitude faster than existing exact methods, and two orders of magnitude faster than a classical bootstrap. Perhaps most importantly, the proposed method also offers a computationally feasible alternative when no known exact or asymptotic methods exist, e.g. GCV and AIC. An application is illustrated by applying the methodology to well‐known fossil data. Giving a range of plausible smoothed values in this instance can help answer questions about the statistical significance of apparent features in the data.     

Transmuted generalized exponential distribution: A generalization of the exponential distribution with applications to survival data

In this article, we investigate the potential usefulness of the three-parameter transmuted generalized exponential distribution for analyzing lifetime data. We compare it with various generalizations of the two-parameter exponential distribution using maximum likelihood estimation. Some mathematical properties of the new extended model including expressions for the quantile and moments are investigated. We propose a location-scale regression model, based on the log-transmuted generalized exponential distribution. Two applications with real data are given to illustrate the proposed family of lifetime distributions.     

Slashed generalized exponential distribution

In this paper, we introduce an extension of the generalized exponential (GE) distribution, making it more robust against possible influential observations. The new model is defined as the quotient between a GE random variable and a beta-distributed random variable with one unknown parameter. The resulting distribution is a distribution with greater kurtosis than the GE distribution. Probability properties of the distribution such as moments and asymmetry and kurtosis are studied. Likewise, statistical properties are investigated using the method of moments and the maximum likelihood approach. Two real data analyses are reported illustrating better performance of the new model over the GE model.     

Prediction of tumour pathological subtype from genomic profile using sparse logistic regression with random effects

The purpose of this study is to highlight the application of sparse logistic regression models in dealing with prediction of tumour pathological subtypes based on lung cancer patients'' genomic information. We consider sparse logistic regression models to deal with the high dimensionality and correlation between genomic regions. In a hierarchical likelihood (HL) method, it is assumed that the random effects follow a normal distribution and its variance is assumed to follow a gamma distribution. This formulation considers ridge and lasso penalties as special cases. We extend the HL penalty to include a ridge penalty (called ‘HLnet’) in a similar principle of the elastic net penalty, which is constructed from lasso penalty. The results indicate that the HL penalty creates more sparse estimates than lasso penalty with comparable prediction performance, while HLnet and elastic net penalties have the best prediction performance in real data. We illustrate the methods in a lung cancer study.     

外商直接投资与中国经济增长关系的多重协整分析

主要依据多重协整理论,从经济系统的角度,利用国内生产总值、外商直接投资、国内固定资产投资、社会消费品零售总额和出口五个指标建立多变量长期均衡的表达式;在多重协整分析的基础上,应用脉冲响应函数和方差分解方法对外商直接投资与经济增长之间的相互影响进行实证分析,得出国内生产总值对外商直接投资有长期影响等四项结论。     

中国产业结构变动与就业水平的实证研究

文章运用时间序列和计量模型研究了中国产业结构与就业水平之间的发展关系.首先运用格兰杰因果检验分析了第一、二、三次产业的产值与其就业之间的因果影响关系,继而从产值与就业两个角度定量分析了第一、二、三次产业各自对总就业水平的贡献,得出结论:第一产业和第三产业是劳动力就业的决定因素,而第二产业不是就业的决定因素;从产值角度来看,第三产业对劳动力就业的贡献最大,从就业角度来看,第一产业的就业对总体就业水平的贡献最高,其次是第三产业,而第二产业的就业对总体就业水平的贡献最小.最后根据研究结论提出相应的建议措施.     

Using a Box–Cox transformation in the analysis of longitudinal data with incomplete responses

We analyse longitudinal data on CD4 cell counts from patients who participated in clinical trials that compared two therapeutic treatments: zidovudine and didanosine. The investigators were interested in modelling the CD4 cell count as a function of treatment, age at base-line and disease stage at base-line. Serious concerns can be raised about the normality assumption of CD4 cell counts that is implicit in many methods and therefore an analysis may have to start with a transformation. Instead of assuming that we know the transformation (e.g. logarithmic) that makes the outcome normal and linearly related to the covariates, we estimate the transformation, by using maximum likelihood, within the Box–Cox family. There has been considerable work on the Box–Cox transformation for univariate regression models. Here, we discuss the Box–Cox transformation for longitudinal regression models when the outcome can be missing over time, and we also implement a maximization method for the likelihood, assumming that the missing data are missing at random.