The Dynamic Model for Cancer Relapse Based on Two-Stage Model of Carcinogenesis

In this article, the time from the start of chemotherapy randomization until cancer relapse is of primary interest. Here, cancer relapse refers to the appearance of the first observable malignant clone after therapy. A dynamic model for cancer relapse after chemotherapy is developed. The model differs from the traditional cure rate models in that it takes into consideration the growth kinetics of malignant tumors using a two-stage carcinogenesis model. The survival and hazard functions for cancer relapse time are derived, and a simulation study is performed to validate the underlying model.     

A comparison of random balance and two-stage group screening designs: A case study

In this paper we focus on the problem of supersaturated (fewer runs than factors) screening experiments. We consider two major types of designs which have been proposed in this situ¬ation: random balance and two-stage group screening. We discuss the relative merits and demerits of each strategy. In addition, we compare the performance of these strategies by means of a case study in which 100 factors are screened in 20,42,62, and 84 runs.     

A Welcome to the International Statistical Conferences

Criteria for assessing the effectiveness of a medical screening program are difficult to define; medical knowledge and screening procedures change rapidly, and self-selection at medical screens is unavoidable. This article discusses these and other basic issues in evaluation of medical screening programs with particular reference to results from the HIP breast cancer study. In addition, the article reviews various statistical models that describe the processes of disease and screening. The models are shown to be statistically indistinguishable in practice because of the small sample sizes typically available in medical screening trials. Finally the article suggests incorporating knowledge from clinical trials and from studies of robustness into statistical models designed to identify reasonable strategies for screening.     

The Optimal Allocation Combination for the One-Sided Sequential Screening Procedure Based on the Individual Misclassification Error

In this article, the expected total costs of three kinds of quality cost functions for the one-sided sequential screening procedure based on the individual misclassification error are obtained, where the expected total cost is the sum of the expected cost of inspection, the expected cost of rejection, and the expected cost of quality. The computational formulas for three kinds of expected total costs are derived when k screening variables are allocated into r stages. The optimal allocation combination is determined based on the criterion of minimum expected total cost. At last, we give one example to illustrate the selection of the optimal allocation combination for the sequential screening procedure.     

Incremental Sampling Methodology: Applications for Background Screening Assessments

This article presents the findings from a numerical simulation study that was conducted to evaluate the performance of alternative statistical analysis methods for background screening assessments when data sets are generated with incremental sampling methods (ISMs). A wide range of background and site conditions are represented in order to test different ISM sampling designs. Both hypothesis tests and upper tolerance limit (UTL) screening methods were implemented following U.S. Environmental Protection Agency (USEPA) guidance for specifying error rates. The simulations show that hypothesis testing using two‐sample t ‐tests can meet standard performance criteria under a wide range of conditions, even with relatively small sample sizes. Key factors that affect the performance include unequal population variances and small absolute differences in population means. UTL methods are generally not recommended due to conceptual limitations in the technique when applied to ISM data sets from single decision units and due to insufficient power given standard statistical sample sizes from ISM.     

论王小波对“反智倾向”的文学表现与文化批判

中国文化传统中存在着根深蒂固的反智倾向,对之加以文学表现和文化批判,是王小波文学创作的重要主题。反智倾向着重表现在两个方面,一是剥夺爱智者的求知权利,一是对知识分子的求知活动设限,特别是负筛选和向下拉齐的策略对智性发展以及知识分子主体自由造成极为严重的消极后果,包括对知识的恶意误用、改写,混淆分科之学的价值功用、将科学艺术化,迫使和诱使知识分子自我审查和自我禁锢,等等。王小波针对反智倾向的文学表现和文化批判,揭示了求知权利和能力在主体建构中不可或缺的价值。     

Screening children with a history of maltreatment for post-traumatic stress disorder in frontline social care organizations: A process evaluation

The use of standardized screening tools to identify trauma exposure and associated symptoms is commonly recommended as a key component in the development of trauma informed services and is seen as integral to facilitating access to evidence-based therapies. However, there is limited evidence in the UK about the factors influencing the adoption of such tools into routine practice in children's social care. This paper presents the findings from a process evaluation of how practitioners implemented a screening tool for post-traumatic stress disorder, anxiety and depression into their day-to-say practice and what worked or did not work during the process. The findings from this study highlight the potential benefits for both young people and practitioners, alongside some of the challenges involved. In particular, practitioners need to see the direct benefit for young people of being assessed. Additionally, practitioners value regular mentoring as they become more proficient in using standardized screening tools.