地球化学环境与地方病

通过对地方病 (主要介绍地方性甲状腺肿、克山病和地方性氟中毒 )与环境联系的介绍 ,从环境的角度认识地方病产生的原因 ,使人们认识一些地方病产生的地球化学成因 ,并通过调节人类自身的行为来预防地方病 ,使人们能够更加科学、健康地生活。     

Ethnicity as a risk indicator for musculoskeletal disease, long consultation times and care utilization A prospective visitor study of 438 consecutive adult consultations of a primary health care centre

This article shows the influence of ethnicity (people born outside Sweden and in Sweden) and social class (socioeconomic class) on the distribution of diagnoses, consultation time and health care utilization in primary health care controlled for sex, age, marital status and educational level. The study was designed as a prospective primary health care utilization study during 7 consecutive weeks. Of a total of 439 adults who lived in the residential area, 290 were born in Sweden and 149 were born elsewhere. The data were analysed unmatched with logistic regression and Poisson regression in main effect models. People born outside Sweden received significantly more diagnoses per consultation than people born in Sweden. The strongest independent risk indicator for musculoskeletal disease was being born outside Sweden, with an estimated odds ratio (OR) of 5.01, 95% confidence interval (CI) = 2.70–8.72. Age over 44 was associated with increased odds for musculoskeletal disease. Respiratory disease, as an indicator of less serious disease, were significantly less common among people born outside Sweden (OR = 0.53, 95% CI = 0.33–0.87). Being born outside Sweden was a risk indicator for consultations longer than 30 minutes (OR = 3.03, 95% CI=1.18–7.43). There were no differences between people born in Sweden and those born elsewhere in health and utilization. Social class was not associated with any of the dependent variables.     

NOS3基因与阿尔茨海默病患病风险关联的研究

目的：阿尔茨海默病（ AD）是最常见的神经退行性疾病,与基因的多态性有关,包括内皮一氧化氮合酶3（ NOS3）发生变化。 NOS分解一氧化氮,并且在血脑屏障中起到有关键作用。探索NOS3基因（ rs1799983,G）与中国南方人群阿尔茨海默病患病风险的关联。方法采用病例-对照研究,在74例散发性患者和139例对照者中,对NOS3基因（rs1799983, G）进行两组间的等位基因及遗传模型基因型差异分析,NOS3基因使用聚合酶连反应-限制性内切酶（ PCR-RFLP）方法分型并测序进行验证。结果①NOS3基因（rs1799983,G）风险等位基因和基因型的频率在病例组和对照间组间的分布无显著性差异（P＞0.05）。②NOS3基因（rs1799983,G）在AD患者中携带ApoE4与非携带ApoEε4两组间基因型频率无显著性差异。结论研究显示NOS3基因rs1799983,G可能与中国南方人群AD患病风险无关联。     

Waterborne Disease‐Related Risk Perceptions in the Sonora River Basin,Mexico

Waterborne disease is estimated to cause about 10% of all diseases worldwide. However, related risk perceptions are not well understood, particularly in the developing world where waterborne disease is an enormous problem. We focus on understanding risk perceptions related to these issues in a region within northern Mexico. Our findings show how waterborne disease problems and solutions are understood in eight small communities along a highly contaminated river system. We found major differences in risk perceptions between health professionals, government officials, and lay citizens. Health professionals believed that a high level of human‐waste‐related risk existed within the region. Few officials and lay citizens shared this belief. In addition, few officials and lay citizens were aware of poor wastewater‐management‐related disease outbreaks and water contamination. Finally, aside from health professionals, a few interviewees understood the importance of basic hygiene and water treatment measures that could help to prevent disease. Our results add to the literature on environmentally‐related risk perceptions in the developing world. We discuss recommendations for improving future human‐wastewater‐related risk communication within the region.     

Dynamic Impacts of a Catastrophic Production Event: The Foot‐and‐Mouth Disease Case

In foot‐and‐mouth disease (FMD) free countries, the occurrence of an FMD outbreak is a rare event with potentially large economic losses. We explore the dynamic effects of an FMD outbreak on market variables and economic surplus taking into account the largely neglected issue of farm bankruptcy. Simulations are performed on a stylized agricultural economy, which is a net exporter before the outbreak. We find complex dynamic market effects when the farm credit market suffers from information imperfections leading to farm closure. Welfare effects are also dramatically altered. Domestic consumers may lose in the long run from an FMD outbreak because domestic supply contracts. On the other hand, farmers able to resist this event may ultimately gain. Our analysis also shows that these effects are not monotone, making any efficient policy response to this catastrophic event quite challenging.     

Affective and Cognitive Factors Influencing Sensitivity to Probabilistic Information

In study 1 different groups of female students were randomly assigned to one of four probabilistic information formats. Five different levels of probability of a genetic disease in an unborn child were presented to participants (within‐subject factor). After the presentation of the probability level, participants were requested to indicate the acceptable level of pain they would tolerate to avoid the disease (in their unborn child), their subjective evaluation of the disease risk, and their subjective evaluation of being worried by this risk. The results of study 1 confirmed the hypothesis that an experience‐based probability format decreases the subjective sense of worry about the disease, thus, presumably, weakening the tendency to overrate the probability of rare events. Study 2 showed that for the emotionally laden stimuli, the experience‐based probability format resulted in higher sensitivity to probability variations than other formats of probabilistic information. These advantages of the experience‐based probability format are interpreted in terms of two systems of information processing: the rational deliberative versus the affective experiential and the principle of stimulus‐response compatibility.     

A case–control study relating railroad worker mortality to diesel exhaust exposure using a threshold regression model

A case–control study of lung cancer mortality in U.S. railroad workers in jobs with and without diesel exhaust exposure is reanalyzed using a new threshold regression methodology. The study included 1256 workers who died of lung cancer and 2385 controls who died primarily of circulatory system diseases. Diesel exhaust exposure was assessed using railroad job history from the US Railroad Retirement Board and an industrial hygiene survey. Smoking habits were available from next-of-kin and potential asbestos exposure was assessed by job history review. The new analysis reassesses lung cancer mortality and examines circulatory system disease mortality. Jobs with regular exposure to diesel exhaust had a survival pattern characterized by an initial delay in mortality, followed by a rapid deterioration of health prior to death. The pattern is seen in subjects dying of lung cancer, circulatory system diseases, and other causes. The unique pattern is illustrated using a new type of Kaplan–Meier survival plot in which the time scale represents a measure of disease progression rather than calendar time. The disease progression scale accounts for a healthy-worker effect when describing the effects of cumulative exposures on mortality.     

性病隐喻与两性身体叙事——中国现代文学中的“性病”意象探析

性病是中国现代文学中最典型的疾病意象之一，对性病的关注涉及对妓女生活的想象，而性别文化身份的差异在对妓女的叙事上体现为两种不同的身体叙事方式。男性主体的中心意识使文学创作更多地表现为人民伦理的宏大叙事，体现着“民族一国家”的“大意义”；女性的历史边缘处境使女性书写更多地呈现为自由伦理的私人叙事，作为一种“小意义”而存在着。对于文学作品中出现的性病，宏大叙事侧重于把女性身体编织进政治、道德、历史的意义圈，强调女性身体的公共性；私人叙事强调性病之于女性的私人经验，呈现女性身体的私人性。     

论《沉沦》的“病态叙事”

试图通过对《沉沦》中郁达夫有意识无意识的“病态叙事”，来发掘小说的深刻内蕴；指出在郁达夫的作品中，主人公大都是“有病”的人，作者采取了“病态叙事”这种方式来展现和表达自己的内心痛苦，从而揭示五四一代先进知识分子普遍的痛苦和绝望。     

灭虫丁和敌百虫同用治疗家兔螨病试验

将患螨病的家兔24只随机分成3组,每组8只,Ⅰ组以灭虫丁注射液O.2mg/kg皮下注射1次,Ⅱ组用2％敌百虫溶液外擦,每天2次,连续3d,Ⅲ组则前两种方法都用,考察疗效及增重情况。结果表明:用药后14d,Ⅲ组疗效最好,平均增重140g,差异极显著。