A resampling procedure for nonparametric combination of several dependent tests

Summary This paper deals with nonparametric methods for combining dependent permutation or randomization tests. Particularly, they are nonparametric with respect to the underlying dependence structure. The methods are based on a without replacement resampling procedure (WRRP) conditional on the observed data, also called conditional simulation, which provide suitable estimates, as good as computing time permits, of the permutational distribution of any statistic. A class C of combining functions is characterized in such a way that all its members, under suitable and reasonable conditions, are found to be consistent and unbiased. Moreover, for some of its members, their almost sure asymptotic equivalence with respect to best tests, in particular cases, is shown. An applicational example to a multivariate permutationalt-paired test is also discussed.     

Recent trends and developments in computational multivariate analysis

Many traditional multivariate techniques such as ordination, clustering, classification and discriminant analysis are now routinely used in most fields of application. However, the past decade has seen considerable new developments, particularly in computational multivariate methodology. This article traces some of these developments and highlights those trends that may prove most fruitful for future practical implementation.     

Inference for Quantiles of a Finite Population: Asymptotic versus Resampling Results

The aim of the paper is to study the problem of estimating the quantile function of a finite population. Attention is first focused on point estimation, and asymptotic results are obtained. Confidence intervals are then constructed, based on both the following: (i) asymptotic results and (ii) a resampling technique based on rescaling the ‘usual’ bootstrap. A simulation study to compare asymptotic and resampling‐based results, as well as an application to a real population, is finally performed.     

A test of separate hypotheses for comparing linear mixed models with non nested fixed effects

As researchers increasingly rely on linear mixed models to characterize longitudinal data, there is a need for improved techniques for selecting among this class of models which requires specification of both fixed and random effects via a mean model and variance-covariance structure. The process is further complicated when fixed and/or random effects are non nested between models. This paper explores the development of a hypothesis test to compare non nested linear mixed models based on extensions of the work begun by Sir David Cox. We assess the robustness of this approach for comparing models containing correlated measures of body fat for predicting longitudinal cardiometabolic risk.     

Parametric bootstrap inferences for unbalanced panel data models

This article presents parametric bootstrap (PB) approaches for hypothesis testing and interval estimation for the regression coefficients of panel data regression models with incomplete panels. Some simulation results are presented to compare the performance of the PB approaches with the approximate inferences. Our studies show that the PB approaches perform satisfactorily for various sample sizes and parameter configurations, and the performance of PB approaches is mostly better than the approximate methods with respect to the coverage probabilities and the Type I error rates. The PB inferences have almost exact coverage probabilities and Type I error rates. Furthermore, the PB procedure can be simply carried out by a few simulation steps, and the derivation is easier to understand and to be extended to the multi-way error component regression models with unbalanced panels. Finally, the proposed approaches are illustrated by using a real data example.     

Weighted quantile regression with missing covariates using empirical likelihood

This paper proposes an empirical likelihood-based weighted (ELW) quantile regression approach for estimating the conditional quantiles when some covariates are missing at random. The proposed ELW estimator is computationally simple and achieves semiparametric efficiency if the probability of missingness is correctly specified. The limiting covariance matrix of the ELW estimator can be estimated by a resampling technique, which does not involve nonparametric density estimation or numerical derivatives. Simulation results show that the ELW method works remarkably well in finite samples. A real data example is used to illustrate the proposed ELW method.     

IMPORTANCE BOOTSTRAP RESAMPLING FOR PROPORTIONAL HAZARDS REGRESSION

Importance resampling is an approach that uses exponential tilting to reduce the resampling necessary for the construction of nonparametric bootstrap confidence intervals. The properties of bootstrap importance confidence intervals are well established when the data is a smooth function of means and when there is no censoring. However, in the framework of survival or time-to-event data, the asymptotic properties of importance resampling have not been rigorously studied, mainly because of the unduly complicated theory incurred when data is censored. This paper uses extensive simulation to show that, for parameter estimates arising from fitting Cox proportional hazards models, importance bootstrap confidence intervals can be constructed if the importance resampling probabilities of the records for the n individuals in the study are determined by the empirical influence function for the parameter of interest. Our results show that, compared to uniform resampling, importance resampling improves the relative mean-squared-error (MSE) efficiency by a factor of nine (for n = 200). The efficiency increases significantly with sample size, is mildly associated with the amount of censoring, but decreases slightly as the number of bootstrap resamples increases. The extra CPU time requirement for calculating importance resamples is negligible when compared to the large improvement in MSE efficiency. The method is illustrated through an application to data on chronic lymphocytic leukemia, which highlights that the bootstrap confidence interval is the preferred alternative to large sample inferences when the distribution of a specific covariate deviates from normality. Our results imply that, because of its computational efficiency, importance resampling is recommended whenever bootstrap methodology is implemented in a survival framework. Its use is particularly important when complex covariates are involved or the survival problem to be solved is part of a larger problem; for instance, when determining confidence bounds for models linking survival time with clusters identified in gene expression microarray data.     

Assessing different uncertainty measures of EBLUP: a resampling-based approach

The empirical best linear unbiased prediction approach is a popular method for the estimation of small area parameters. However, the estimation of reliable mean squared prediction error (MSPE) of the estimated best linear unbiased predictors (EBLUP) is a complicated process. In this paper we study the use of resampling methods for MSPE estimation of the EBLUP. A cross-sectional and time-series stationary small area model is used to provide estimates in small areas. Under this model, a parametric bootstrap procedure and a weighted jackknife method are introduced. A Monte Carlo simulation study is conducted in order to compare the performance of different resampling-based measures of uncertainty of the EBLUP with the analytical approximation. Our empirical results show that the proposed resampling-based approaches performed better than the analytical approximation in several situations, although in some cases they tend to underestimate the true MSPE of the EBLUP in a higher number of small areas.     

Bootstrap confidence regions for correspondence analysis

A bootstrap-based method for constructing confidence regions (CRs) around row or column points projected onto a pair of axes from the correspondence analysis (CA) of a two-way contingency table is presented. These regions deal with the specific question of the sampling variation of sample row and column profile points around population row and column profile points when both are projected onto the observed axes, rather than the decomposition of the χ²-test of independence or the general question of the stability of the observed CA display which has been considered in previous work. The method therefore constructs the regions in a different way to what has been proposed before. A simulation experiment shows that the method performs well in most of the situations in which it might be used, with a few exceptions being noted. An example illustrates that the method produces conclusions which are consistent with those from detailed parametric modelling.     

Regression analysis of clustered interval-censored failure time data with linear transformation models in the presence of informative cluster size

This paper discusses regression analysis of clustered interval-censored failure time data, which often occur in medical follow-up studies among other areas. For such data, sometimes the failure time may be related to the cluster size, the number of subjects within each cluster or we have informative cluster sizes. For the problem, we present a within-cluster resampling method for the situation where the failure time of interest can be described by a class of linear transformation models. In addition to the establishment of the asymptotic properties of the proposed estimators of regression parameters, an extensive simulation study is conducted for the assessment of the finite sample properties of the proposed method and suggests that it works well in practical situations. An application to the example that motivated this study is also provided.