A class of semiparametric transormation frailty models with application to estimating treatment effects and heterogenity in aids clinical traials

Muitivariate failure time data are common in medical research; com¬monly used statistical models for such correlated failure-time data include frailty and marginal models. Both types of models most often assume pro¬portional hazards (Cox, 1972); but the Cox model may not fit the data well This article presents a class of linear transformation frailty models that in¬cludes, as a special case, the proportional hazards model with frailty. We then propose approximate procedures to derive the best linear unbiased es¬timates and predictors of the regression parameters and frailties. We apply the proposed methods to analyze results of a clinical trial of different dose levels of didansine (ddl) among HIV-infected patients who were intolerant of zidovudine (ZDV). These methods yield estimates of treatment effects and of frailties corresponding to patient groups defined by clinical history prior to entry into the trial.     

Nonparametric maximum likelihood estimation for artificially truncated absence data

In manpower planning it is cornmoniy tue case tnat employees withuraw from active service for a period of time before returning to take up post at a later date. Such periods of absence are frequently of major concern to employers who are anxious to ensure that employees return as soon as possible. The distribution of duration of such periods of absence are therefore of considerable interest as is the probability that such employees will ever return to active service. In this paper we derive a nonparametric estimator for such a lifetime distribution based on renewal data which are subject to various forms of incompleteness, namely right censoring, left and right truncation, and forward recurrence. Artificial truncation is used to ensure that the data are time homogeneous. A nonparametric maximum likelihood estimator for the lifetime.     

Clustering large number of extragalactic spectra of galaxies and quasars through canopies

Abstract

Cluster analysis is the distribution of objects into different groups or more precisely the partitioning of a data set into subsets (clusters) so that the data in subsets share some common trait according to some distance measure. Unlike classification, in clustering one has to first decide the optimum number of clusters and then assign the objects into different clusters. Solution of such problems for a large number of high dimensional data points is quite complicated and most of the existing algorithms will not perform properly. In the present work a new clustering technique applicable to large data set has been used to cluster the spectra of 702248 galaxies and quasars having 1,540 points in wavelength range imposed by the instrument. The proposed technique has successfully discovered five clusters from this 702,248X1,540 data matrix.     

A model with long-term survivors: negative binomial Birnbaum-Saunders

Abstract

We propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the negative binomial distribution and the time to the event of interest has the Birnbaum-Saunders distribution. Further, the new model includes as special cases some well-known cure rate models published recently. We consider a frequentist analysis for parameter estimation of the negative binomial Birnbaum-Saunders model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We illustrate the usefulness of the proposed model in the analysis of a real data set from the medical area.     

Estimation of the covariance matrix with two-step monotone missing data

Abstract

We suggest shrinkage based technique for estimating covariance matrix in the high-dimensional normal model with missing data. Our approach is based on the monotone missing scheme assumption, meaning that missing values patterns occur completely at random. Our asymptotic framework allows the dimensionality p grow to infinity together with the sample size, N, and extends the methodology of Ledoit and Wolf (2004) Ledoit, O., Wolf, M. (2004). A well-conditioned estimator for large dimensional covariance matrices. J. Multivariate Anal. 88:365–411.[Crossref], [Web of Science ®] , [Google Scholar] to the case of two-step monotone missing data. Two new shrinkage-type estimators are derived and their dominance properties over the Ledoit and Wolf (2004) Ledoit, O., Wolf, M. (2004). A well-conditioned estimator for large dimensional covariance matrices. J. Multivariate Anal. 88:365–411.[Crossref], [Web of Science ®] , [Google Scholar] estimator are shown under the expected quadratic loss. We perform a simulation study and conclude that the proposed estimators are successful for a range of missing data scenarios.     

A proportional hazards model for the analysis of doubly censored competing risks data

ABSTRACT

Competing risks data are common in medical research in which lifetime of individuals can be classified in terms of causes of failure. In survival or reliability studies, it is common that the patients (objects) are subjected to both left censoring and right censoring, which is refereed as double censoring. The analysis of doubly censored competing risks data in presence of covariates is the objective of this study. We propose a proportional hazards model for the analysis of doubly censored competing risks data, using the hazard rate functions of Gray (1988 Gray, R.J. (1988). A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann. Statist. 16:1141–1154.[Crossref], [Web of Science ®] , [Google Scholar]), while focusing upon one major cause of failure. We derive estimators for regression parameter vector and cumulative baseline cause specific hazard rate function. Asymptotic properties of the estimators are discussed. A simulation study is conducted to assess the finite sample behavior of the proposed estimators. We illustrate the method using a real life doubly censored competing risks data.     

Modeling of covariance structures of random effects and random errors in linear mixed models

Abstract

In this paper, we discuss how to model the mean and covariancestructures in linear mixed models (LMMs) simultaneously. We propose a data-driven method to modelcovariance structures of the random effects and random errors in the LMMs. Parameter estimation in the mean and covariances is considered by using EM algorithm, and standard errors of the parameter estimates are calculated through Louis’ (1982 Louis, T.A. (1982). Finding observed information using the EM algorithm. J. Royal Stat. Soc. B 44:98–130. [Google Scholar]) information principle. Kenward’s (1987 Kenward, M.G. (1987). A method for comparing profiles of repeated measurements. Appl. Stat. 36:296–308.[Crossref], [Web of Science ®] , [Google Scholar]) cattle data sets are analyzed for illustration,and comparison to the literature work is made through simulation studies. Our numerical analysis confirms the superiority of the proposed method to existing approaches in terms of Akaike information criterion.     

An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.     

Nonnested Testing for Competing Autoregressive Dynamic Models Estimated by Instrumental Variables

In this work we investigate nonnested tests for two competing univariate dynamic linear models with autoregressive disturbances, where the motivation for instrumental variable estimation is mainly due to the recognized presence of current endogenous variables in the regression function, either in one or both models. As the previous transformation of both models yields regression functions which are nonlinear in the parameters, the attractive Gauss-Newton regression (GNR) approach, firstly advocated by Davidson and Mackinnon (1981 Davidson , R. , Mackinnon , J. G. ( 1981 ). Several tests for model specification in the presence of alternative hypotheses . Econometrica 49 : 781 – 93 .[Crossref], [Web of Science ®] , [Google Scholar]), will be used to obtain the results.     

A Numerical Method for Estimating the Variance of Age at Maximum Growth Rate in Growth Models

Studies on maturation and body composition mention age at peak height velocity (PHV) as an important measure that could predict adulthood outcome. The age at PHV is often derived from growth models such as the triple logistic fitted to the stature (height) data. Theoretically, for a well-behaved growth function, age at PHV could be obtained by setting the second derivative of the growth function to zero and solving for age. Such a solution obviously depends on the parameters of the growth function. Therefore, the uncertainty in the estimation of age at PHV resulting from the uncertainty in the estimation of the growth model, need to be accounted for in the models in which it is used as a predictor. Explicit expressions for the age at PHV and, consequently the variance of the estimate of the age at PHV, do not exist for some of the commonly used nonlinear growth functions, such as the triple logistic function. Once an estimate of this variance is obtained, it could be incorporated in subsequent modeling either through measurement error models or by using the inverse variances as weights. A numerical method for estimating the variance is implemented. The accuracy of this method is demonstrated through comparisons in models where explicit solution for the variance exists. The method of estimating the variance is illustrated by applying to growth data from the Fels study and subsequently used as weights in modeling two adulthood outcomes from the same study.