Development of predictive signatures for treatment selection in precision medicine with survival outcomes

For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker‐positive and biomarker‐negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially. We utilize a univariate composite score method to convert the set of patient's candidate biomarkers to a univariate response score. We propose applying the likelihood ratio test (LRT) to assess homogeneity of the sampled patients to address the first issue. In the context of identification of the subgroup of responders in adaptive design to demonstrate improvement of treatment efficacy (adaptive power), we suggest that subgroup selection is carried out if the LRT is significant. For the second issue, we utilize a likelihood‐based change‐point algorithm to find an optimal cutoff. Our simulation study shows that type I error generally is controlled, while the overall adaptive power to detect treatment effects sacrifices approximately 4.5% for the simulation designs considered by performing the LRT; furthermore, the change‐point algorithm outperforms the median cutoff considerably when the subgroup sizes differ substantially.     

Imagined mosque communities in Russia: Central Asian migrants in Moscow

ABSTRACT

The article aims to shed light on mosque communities in Russia through the example of mosques frequented by Moscovites and by Central Asian migrants. I will make use of Anderson’s theoretical framework of ‘imagined community’ in analysing the material presented in the article. The main argument is that there are no real mosque communities and rather that the sense of community formed around mosques is imagined. There are nevertheless a variety of networks, groups and institutions within and around mosques. The article is based on fieldwork conducted in 2016 and 2017.     

央行沟通对于货币政策实际干预的预测能力研究

信息沟通有助于公众理解和预测货币政策的实际干预,进而提高货币政策有效性。研究中国人民银行的信息沟通对实际政策干预的预测能力需要解决沟通文本的测度问题,同时考虑实际政策干预多工具并用的复杂性。基于此,本文通过文本分析方法提取《货币政策执行报告》的信息,进而考察央行沟通对于货币政策实际干预的预测能力。研究表明,整体而言,市场对中国人民银行“听其言”有助于“观其行”。具体来看,央行沟通对于直接可控的基准利率和存款准备金率具有持续的预测能力,但对于市场利率的预测能力较差,对于M2增长率的预测甚至存在方向不一致的情况。     

Some new constructions of circular balanced repeated measurements designs

Repeated measurements designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this article, some infinite series are developed to generate the balanced repeated measurements designs for p (periods) even. For p odd, construction procedures are also described. Catalogues of the proposed designs are also presented for p = 5, 7, 9, when v ≤ 100.     

Survival and lifetime data analysis with a flexible class of distributions

We introduce a general class of continuous univariate distributions with positive support obtained by transforming the class of two-piece distributions. We show that this class of distributions is very flexible, easy to implement, and contains members that can capture different tail behaviours and shapes, producing also a variety of hazard functions. The proposed distributions represent a flexible alternative to the classical choices such as the log-normal, Gamma, and Weibull distributions. We investigate empirically the inferential properties of the proposed models through an extensive simulation study. We present some applications using real data in the contexts of time-to-event and accelerated failure time models. In the second kind of applications, we explore the use of these models in the estimation of the distribution of the individual remaining life.     

Applications of quadrivariate exponential distribution to a three-unit warm standby system with dependent structure

Two-unit warm standby systems have been elaborately dealt within the literature. However, the study of standby systems with more than two units, though very relevant in state-of-the-art practical situations, has received little attention because of mathematical intricacies involved in analyzing them. Also, such systems have been studied assuming: (i) the lifetime or repair time of the units to be exponential, or (ii) the lifetime and repair time to be independent. The present contribution is an improvement in the state-of-the-art in the sense that three-unit warm standby system with dependent structure is shown to be capable of comprehensive analysis.     

Composite Estimation for Single‐Index Models with Responses Subject to Detection Limits

We propose a semiparametric estimator for single‐index models with censored responses due to detection limits. In the presence of left censoring, the mean function cannot be identified without any parametric distributional assumptions, but the quantile function is still identifiable at upper quantile levels. To avoid parametric distributional assumption, we propose to fit censored quantile regression and combine information across quantile levels to estimate the unknown smooth link function and the index parameter. Under some regularity conditions, we show that the estimated link function achieves the non‐parametric optimal convergence rate, and the estimated index parameter is asymptotically normal. The simulation study shows that the proposed estimator is competitive with the omniscient least squares estimator based on the latent uncensored responses for data with normal errors but much more efficient for heavy‐tailed data under light and moderate censoring. The practical value of the proposed method is demonstrated through the analysis of a human immunodeficiency virus antibody data set.     

Small area estimation strategies for large population surveys: a comparison of design and model-based methods

Small area estimation (SAE) concerns with how to reliably estimate population quantities of interest when some areas or domains have very limited samples. This is an important issue in large population surveys, because the geographical areas or groups with only small samples or even no samples are often of interest to researchers and policy-makers. For example, large population health surveys, such as Behavioural Risk Factor Surveillance System and Ohio Mecaid Assessment Survey (OMAS), are regularly conducted for monitoring insurance coverage and healthcare utilization. Classic approaches usually provide accurate estimators at the state level or large geographical region level, but they fail to provide reliable estimators for many rural counties where the samples are sparse. Moreover, a systematic evaluation of the performances of the SAE methods in real-world setting is lacking in the literature. In this paper, we propose a Bayesian hierarchical model with constraints on the parameter space and show that it provides superior estimators for county-level adult uninsured rates in Ohio based on the 2012 OMAS data. Furthermore, we perform extensive simulation studies to compare our methods with a collection of common SAE strategies, including direct estimators, synthetic estimators, composite estimators, and Datta GS, Ghosh M, Steorts R, Maples J.'s [Bayesian benchmarking with applications to small area estimation. Test 2011;20(3):574–588] Bayesian hierarchical model-based estimators. To set a fair basis for comparison, we generate our simulation data with characteristics mimicking the real OMAS data, so that neither model-based nor design-based strategies use the true model specification. The estimators based on our proposed model are shown to outperform other estimators for small areas in both simulation study and real data analysis.     

Decomposition of Variance for Spatial Cox Processes

Abstract. Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introduce a general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models with additive or log linear random intensity functions. We moreover consider a new and flexible class of pair correlation function models given in terms of normal variance mixture covariance functions. The proposed methodology is applied to point pattern data sets of locations of tropical rain forest trees.