Some computational problems related to multinomial trials

Efficient numerical algorithms are developed to evaluate several probabilities related to multinomial trials.In the first part of the paper, the probability distribution of the number of trials until the alternatives j, j = 1,… m, have occurred at least i_j times is computed. The multinomial trials involve the m alternatives l,…, m, with positive probabilities P_l-P_m of occurrence. In the second part, several aspects of a multinomial subset selection problem, discussed by S. S. Gupta and K. Nagel, are investigated.     

集群创新研究的方法论综述

集群创新体现了现代互动性创新的系统特点,是现代创新体系不可分割的一部分。从方法论的角度看,集群创新的相关研究主要运用了定性研究、案例分析、统计研究和社会网络分析等方法,对此本文从方法运用角度回顾了相关研究,并从研究问题、研究结果、管理涵义等方面对主要文献做了比较和评论,在此基础上总结了各研究方法的优缺点及适用性,以及未来方法综合运用的趋势,供相关研究借鉴参考。     

A Note on the Poisson Likelihood Ratio Test Statistic for Kulldorff's Scan Methods

Methods based on scan statistics are widely used in health-related applications to detect clusters of disease. The most common methods are based on the Bernoulli and Poisson models. Kulldorff (1997 Kulldorff , M. ( 1997 ). A spatial scan statistic . Communications in Statistics—Theory and Methods 26 : 1481 – 1496 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) derived the likelihood ratio test statistic for his scan method for both of these models. His scan statistic is widely used with freely available software, SaTScan^? (see Kulldorff, 2005 Kulldorff , M. ( 2005 ). SaTScan: software for the spatial, temporal, and space-time scan statistics , version 5.1 [computer program]. Information Management Services 2005; Available: http://www.satscan.org/. Accessed July 2007 . [Google Scholar]). We provide an alternative derivation of the likelihood ratio test statistic in the Poisson case. Our derivation is simpler and more general in the sense that it applies when the incidences are not aggregated into subregional counts.     

Linear Subspace Spanned by Principal Points of a Mixture of Spherically Symmetric Distributions

For each positive integer k, a set of k-principal points of a distribution is the set of k points that optimally represent the distribution in terms of mean squared distance. However, explicit form of k-principal points is often difficult to obtain. Hence a theorem established by Tarpey et al. (1995 Tarpey , T. , Li , L. , Flury , B. D. ( 1995 ). Principal points and self-consistent points of elliptical distributions . Ann. Statist. 23 : 102 – 112 .[Crossref], [Web of Science ®] , [Google Scholar]) has been influential in the literature, which states that when the distribution is elliptically symmetric, any set of k-principal points is in the linear subspace spanned by some principal eigenvectors of the covariance matrix. This theorem is called a “principal subspace theorem”. Recently, Yamamoto and Shinozaki (2000b Yamamoto , W. , Shinozaki , N. ( 2000b ). Two principal points for multivariate location mixtures of spherically symmetric distributions . J. Japan Statist. Soc. 30 : 53 – 63 .[Crossref] , [Google Scholar]) derived a principal subspace theorem for 2-principal points of a location mixture of spherically symmetric distributions. In their article, the ratio of mixture was set to be equal. This article derives a further result by considering a location mixture with unequal mixture ratio.     

Detection and Interpretation of a Multivariate Signal Using Combined Charts

A control procedure is presented in this article that is based on jointly using two separate control statistics in the detection and interpretation of signals in a multivariate normal process. The procedure detects the following three situations: (i) a mean vector shift without a shift in the covariance matrix; (ii) a shift in process variation (covariance matrix) without a mean vector shift; and (iii) both a simultaneous shift in the mean vector and covariance matrix as the result of a change in the parameters of some key process variables. It is shown that, following the occurrence of a signal on either of the separate control charts, the values from both of the corresponding signaling statistics can be decomposed into interpretable elements. Viewing the two decompositions together helps one to specifically identify the individual components and associated variables that are being affected. These components may include individual means or variances of the process variables as well as the correlations between or among variables. An industrial data set is used to illustrate the procedure.     

Spatial Cluster Detection for Longitudinal Outcomes Using Administrative Regions

This article proposes a new spatial cluster detection method for longitudinal outcomes that detects neighborhoods and regions with elevated rates of disease while controlling for individual level confounders. The proposed method, CumResPerm, utilizes cumulative geographic residuals through a permutation test to detect potential clusters which are defined as sets of administrative regions, such as a town or group of administrative regions. Previous cluster detection methods are not able to incorporate individual level data including covariate adjustment, while still being able to define potential clusters using informative neighborhood or town boundaries. Often, it is of interest to detect such spatial clusters because individuals residing in a town may have similar environmental exposures or socioeconomic backgrounds due to administrative reasons, such as zoning laws. Therefore, these boundaries can be very informative and more relevant than arbitrary clusters such as the standard circle or square. Application of the CumResPerm method will be illustrated by the Home Allergens and Asthma prospective cohort study analyzing the relationship between area or neighborhood residence and repeated measured outcome, occurrence of wheeze in the last six months, while taking into account mobile locations.     

Randomized Response Techniques Using Maximum Likelihood Estimator

The randomized response (RR) technique with two decks of cards proposed by Odumade and Singh (2009) can always be made more efficient than the RR techniques proposed by Warner (1965), Mangat and Singh (1990), and Mangat (1994) by adjusting the proportion of cards in the decks. Arnab et al. (2012) generalized Odumade and Singh strategy (2009) for complex survey designs and wider class of estimators. In this paper improvement of Arnab et al. (2012) estimator has been made by using maximum likelihood method.     

Bayesian credibility limits for small finite population proportions:stratified and cluster sampling

Bayes credibility limits for small proportions from stratified and fixed size cluster samples are discussed. Ericson’s (JRSS B (1969)) Beta Binomial and Dirichlet-Multinomial priors are used. Approximate limits that are appropriate for large samples and small proportions are derived in both cases. These allow asymptotic comparisons of the efficacy of stratified and cluster sampling relative to simple random sampling for estimating small proportions. Procedures for the selection of hyper parameters are also presented.     

Assessing multiple endpoints with ordered alternatives

Nonparametric approaches to the analysis of multiple endpoints in clinical studies can be of particular value when the endpoints are heterogeneous or distributional assumptions are suspect. We describe a multivariate Terpstra-Jonckheere U-statistic for assessing multiple endpoints with ordered alternatives, and illustrate its use with data arising from a recent clinical study.