A property of coefficients of variation for ordered bivariate log-normal variables

This paper considers the maximum and minimum of a pair of log-normal variables with equal mean. It shows that either order statistic has a smaller coefficient of variation than the two original log-normal variables provided the latter are of equal variance. When the variances are unequal, as the variance ratio increases, the minimum (maximum), has a smaller coefficient of variation if the correlation coefficient of the log-normal variables is small (small) and the variances are large (small).     

Orientation relationship in finite dimensional space

In the present article, we discuss the regression of a point on the surface of a unit sphere in d dimensions given a point on the surface of a unit sphere in p dimensions, where p may not be equal to d. Point projection is added to the rotation and linear transformation for regression link function. The identifiability of the model is proved. Then, parameter estimation in this set up is discussed. Simulation studies and data analyses are done to illustrate the model.     

Nonparametric Estimation of the Number of Drug Users in Hong Kong Using Repeated Multiple Lists

We update a previous approach to the estimation of the size of an open population when there are multiple lists at each time point. Our motivation is 35 years of longitudinal data on the detection of drug users by the Central Registry of Drug Abuse in Hong Kong. We develop a two‐stage smoothing spline approach. This gives a flexible and easily implemented alternative to the previous method which was based on kernel smoothing. The new method retains the property of reducing the variability of the individual estimates at each time point. We evaluate the new method by means of a simulation study that includes an examination of the effects of variable selection. The new method is then applied to data collected by the Central Registry of Drug Abuse. The parameter estimates obtained are compared with the well known Jolly–Seber estimates based on single capture methods.     

Group sequential monitoring based on the weighted log‐rank test statistic with the Fleming–Harrington class of weights in cancer vaccine studies

In recent years, immunological science has evolved, and cancer vaccines are now approved and available for treating existing cancers. Because cancer vaccines require time to elicit an immune response, a delayed treatment effect is expected and is actually observed in drug approval studies. Accordingly, we propose the evaluation of survival endpoints by weighted log‐rank tests with the Fleming–Harrington class of weights. We consider group sequential monitoring, which allows early efficacy stopping, and determine a semiparametric information fraction for the Fleming–Harrington family of weights, which is necessary for the error spending function. Moreover, we give a flexible survival model in cancer vaccine studies that considers not only the delayed treatment effect but also the long‐term survivors. In a Monte Carlo simulation study, we illustrate that when the primary analysis is a weighted log‐rank test emphasizing the late differences, the proposed information fraction can be a useful alternative to the surrogate information fraction, which is proportional to the number of events. Copyright © 2016 John Wiley & Sons, Ltd.     

Comparison of Interval Estimators of Pr(X < Y) in the Two-parameter Exponential Distribution

We consider confidence intervals for the stress–strength reliability Pr(X< Y) in the two-parameter exponential distribution. We have derived the Bayesian highest posterior density interval using non-informative prior distributions. We have compared its performance with the intervals based on the generalized pivot variable intervals in terms of their coverage probabilities and expected lengths. Our simulation study shows that the Bayesian interval performs better according to the criteria used, especially when the sample sizes are very small. An example is given.     

Probability Generating Function Based Jeffrey's Divergence for Statistical Inference

Statistical inference procedures based on transforms such as characteristic function and probability generating function have been examined by many researchers because they are much simpler than probability density functions. Here, a probability generating function based Jeffrey's divergence measure is proposed for parameter estimation and goodness-of-fit test. Being a member of the M-estimators, the proposed estimator is consistent. Also, the proposed goodness-of-fit test has good statistical power. The proposed divergence measure shows improved performance over existing probability generating function based measures. Real data examples are given to illustrate the proposed parameter estimation method and goodness-of-fit test.     

Temporal Disaggregation: Methods,Information Loss,and Diagnostics

This research provides a generalized framework to disaggregate lower-frequency time series and evaluate the disaggregation performance. The proposed framework combines two models in separate stages: a linear regression model to exploit related independent variables in the first stage and a state–space model to disaggregate the residual from the regression in the second stage. For the purpose of providing a set of practical criteria for assessing the disaggregation performance, we measure the information loss that occurs during temporal aggregation while examining what effects take place when aggregating data. To validate the proposed framework, we implement Monte Carlo simulations and provide two empirical studies. Supplementary materials for this article are available online.     

Local influence diagnostics for incomplete overdispersed longitudinal counts

We develop local influence diagnostics to detect influential subjects when generalized linear mixed models are fitted to incomplete longitudinal overdispersed count data. The focus is on the influence stemming from the dropout model specification. In particular, the effect of small perturbations around an MAR specification are examined. The method is applied to data from a longitudinal clinical trial in epileptic patients. The effect on models allowing for overdispersion is contrasted with that on models that do not.