Recovery of inter-block information: extensions in a two variance component model

For a two variance component mixed linear model, it is shown that under suitable conditions there exists a nonlinear unbiased estimator that is better than a best linear unbiased estimator defined with respect to a given singular covariance matrix. It is also shown how this result applies to improving on intra-block estimators and on estimators like the unweighted means estimator in a random one-way model.     

Exact permutation inference for two sample repeated measures data

Experiments in which very few units are measured many times sometimes present particular difficulties. Interest often centers on simple location shifts between two treatment groups, but appropriate modeling of the error distribution can be challenging. For example, normality may be difficult to verify, or a single transformation stabilizing variance or improving normality for all units and all measurements may not exist. We propose an analysis of two sample repeated measures data based on the permutation distribution of units. This provides a distribution free alternative to standard analyses. The analysis includes testing, estimation and confidence intervals. By assuming a certain structure in the location shift model, the dimension of the problem is reduced by analyzing linear combinations of the marginal statistics. Recently proposed algorithms for computation of two sample permutation distributions, require only a few seconds for experiments having as many as 100 units and any number of repeated measures. The test has high asymptotic efficiency and good power with respect to tests based on the normal distribution. Since the computational burden is minimal, approximation of the permutation distribution is unnecessary.     

The effects of covariate adjustment in generalized linear models

Results from classical linear regression regarding the effects of covariate adjustment, with respect to the issues of confounding, the precision with which an exposure effect can be estimated, and the efficiency of hypothesis tests for no treatment effect in randomized experiments, are often assumed to apply more generally to other types of regression models. In this paper results pertaining to several generalized linear models involving a dichotomous response variable are given, demonstrating that with respect to the issues of confounding and precision, for models having a linear or log link function the results of classical linear regression do generally apply, whereas for other models, including those having a logit, probit, log-log, complementary log-log, or generalized logistic link function, the results of classical linear regression do not always apply. It is also shown, however, that for any link function, covariate adjustment results in improved efficiency of hypothesis tests for no treatment effect in randomized experiments, and hence that the classical linear regression results regarding efficiency do apply for all models having a dichotomous response variable.     

Likelihood-based cross-validation score for selecting the smoothing parameter in maximum penalized likelihood estimation

Maximum penalized likelihood estimation is applied in non(semi)-para-metric regression problems, and enables us exploratory identification and diagnostics of nonlinear regression relationships. The smoothing parameter A controls trade-off between the smoothness and the goodness-of-fit of a function. The method of cross-validation is used for selecting A, but the generalized cross-validation, which is based on the squared error criterion, shows bad be¬havior in non-normal distribution and can not often select reasonable A. The purpose of this study is to propose a method which gives more suitable A and to evaluate the performance of it.

A method of simple calculation for the delete-one estimates in the likeli¬hood-based cross-validation (LCV) score is described. A score of similar form to the Akaike information criterion (AIC) is also derived. The proposed scores are compared with the ones of standard procedures by using data sets in liter¬atures. Simulations are performed to compare the patterns of selecting A and overall goodness-of-fit and to evaluate the effects of some factors. The LCV-scores by the simple calculation provide good approximation to the exact one if λ is not extremeiy smaii Furthermore the LCV scores by the simple size it possible to select X adaptively They have the effect, of reducing the bias of estimates and provide better performance in the sense of overall goodness-of fit. These scores are useful especially in the case of small sample size and in the case of binary logistic regression.     

Robust empirical likelihood for linear models under median constraints

In this paper, we consider the application of the empirical likelihood for

linear models under median constraints in view of robustness. For two simple median constraints, it is shown that conditions to ensure the consistency of the empirical likelihood confidence regions can be surprisingly relaxed compared with the normal approach under L norm. However, the coverage accuracy of the empirical likelihood confidence regions based on simple median constrains cannot be improved because of the discontinuity of the constraints. Therefore, a smoothed version of median constraint is proposed and a general theory is established to ensure its validity.     

Superiority comparisons between mixed regression estimators

This paper gives necessary and sufficient conditions for a mixed regression estimator to be superior to another mixed estimator. The comparisons are based on the mean square error matrices of the estimators. Both estimators are allowed to be biased.     

On the existence of linear trend free block designs

We present a class of counerexamples for a conjecture on the existence or linear trend free block designs we will also prove a considerably weakened version of this conjecture which will determine all combinations of designs parmetres for which the class of linear trend free block designs is non empty.     

Equivariant prediction in finite populations

A theory of equivariant prediction is developed for predicting the population total in finite populations. Minimum risk equivariant predictors (MREP) are derived under the location, scale and locationscale superpopulation models. Under the general linear model, it is shown that the best(linear) unbiased predictor (B(L)UP) is an MREP.     

On the power of the durbin-watson test under high autocorrelation

In the linear regression model without an intercept, it is known that the limiting power of the Durbin-Watson test (as correlation among errors increases) equals either one or zero, depending on the underlying regressor matrix. This paper considers the limiting power in the model with an intercept, and proves that it will never equal one or zero.     

Unbiased estimation of a nonlinear function a normal mean with application to measurement err oorf models

Let W be a normal random variable with mean μand known variance σ². Conditions on the function f(·) are given under which there exists an unbiased estimator, f(W), of f(μ) for all real μ. In particular it is shown that f(·) must be an entire function over the complex plane. Infinite series solutions for F(·) are obtained which are shown to be valid under growth conditions of the derivatives, f^k( ·), of f(·). Approximate solutions are given for the cases in which no exact solution exists. The theory is applied to nonlinear measurement-error models as a means of finding unbiased score functions when measurement error is normally distributed. Relative efficiencies comparing the proposed method to the use of conditional scores (Stefanski and Carroll, 1987) are given for the Poisson regression model with canonical link.