Confidence Intervals for the Weighted Sum of Two Independent Binomial Proportions

Confidence intervals for the difference of two binomial proportions are well known, however, confidence intervals for the weighted sum of two binomial proportions are less studied. We develop and compare seven methods for constructing confidence intervals for the weighted sum of two independent binomial proportions. The interval estimates are constructed by inverting the Wald test, the score test and the Likelihood ratio test. The weights can be negative, so our results generalize those for the difference between two independent proportions. We provide a numerical study that shows that these confidence intervals based on large‐sample approximations perform very well, even when a relatively small amount of data is available. The intervals based on the inversion of the score test showed the best performance. Finally, we show that as for the difference of two binomial proportions, adding four pseudo‐outcomes to the Wald interval for the weighted sum of two binomial proportions improves its coverage significantly, and we provide a justification for this correction.     

Markov models of mite movements

Continuous time Markov models were used to analyse data from two bioassays to investigate the influence of β-fraction, a by-product of hop processing, on the two-spotted spider mite. The models were fitted to aggregate counts of the numbers of live and dead mites on treated and untreated halves of discs cut from leaves of hop and French bean plants. Some of the rate parameters were time dependent. Although not all parameters could be estimated precisely, the analysis enabled the quantitative effects of treatment over time to be estimated with reasonable precision. The estimated treatment effects were largely insensitive to the assumed values of other parameters. The first bioassay showed a progressive initial response to increasing concentration of β-fraction, although data at the intermediate concentration appeared anomalous. The second bioassay showed similar responses on hop and French bean leaves, with a stronger repellent effect on the lower leaf surface than on the upper surface.     

Improved likelihood inference in beta regression

We consider the issue of performing accurate small-sample likelihood-based inference in beta regression models, which are useful for modelling continuous proportions that are affected by independent variables. We derive small-sample adjustments to the likelihood ratio statistic in this class of models. The adjusted statistics can be easily implemented from standard statistical software. We present Monte Carlo simulations showing that inference based on the adjusted statistics we propose is much more reliable than that based on the usual likelihood ratio statistic. A real data example is presented.     

Policy deployment: A case study analysis

Theaim of theresearch reported in thispaper wasto examine policy deployment in a business unit of the UK company operation of a major corporation, considered a world leader in business improvement. In this study, the application of policy deployment at an operational level was investigated to determine how managers deploy and manage direction, and assess the effectiveness of the catchball process. In the business unit studied, policy deployment could have a greater impact. For example, in deploying direction, cascade and catchball is used, however, the leadership, checks, control and communication elements could be more effective, and the respective shortcomings are described. A generic catch-reflect-improvescrutinize-pass (CRISP) approach to policy deployment is proposed by which vision, mission, goals, objectives, targets and means can be more effectively deployed.     

A Simulation-Based Specification Test for Diffusion Processes

This article makes two contributions. First, we outline a simple simulation-based framework for constructing conditional distributions for multifactor and multidimensional diffusion processes, for the case where the functional form of the conditional density is unknown. The distributions can be used, for example, to form predictive confidence intervals for time period t + τ, given information up to period t. Second, we use the simulation-based approach to construct a test for the correct specification of a diffusion process. The suggested test is in the spirit of the conditional Kolmogorov test of Andrews. However, in the present context the null conditional distribution is unknown and is replaced by its simulated counterpart. The limiting distribution of the test statistic is not nuisance parameter-free. In light of this, asymptotically valid critical values are obtained via appropriate use of the block bootstrap. The suggested test has power against a larger class of alternatives than tests that are constructed using marginal distributions/densities. The findings of a small Monte Carlo experiment underscore the good finite sample properties of the proposed test, and an empirical illustration underscores the ease with which the proposed simulation and testing methodology can be applied.     

Nonparametric estimation of a two dimensional continuous–discrete density function by wavelets

We consider the estimation of a two dimensional continuous–discrete density function. A new methodology based on wavelets is proposed. We construct a linear wavelet estimator and a non-linear wavelet estimator based on a term-by-term thresholding. Their rates of convergence are established under the mean integrated squared error over Besov balls. In particular, we prove that our adaptive wavelet estimator attains a fast rate of convergence. A simulation study illustrates the usefulness of the proposed estimators.     

On beta regression residuals

We propose two new residuals for the class of beta regression models, and numerically evaluate their behaviour relative to the residuals proposed by Ferrari and Cribari-Neto. Monte Carlo simulation results and empirical applications using real and simulated data are provided. The results favour one of the residuals we propose.     

Bayesian analysis of single-molecule experimental data

Summary.  Recent advances in experimental technologies allow scientists to follow biochemical processes on a single-molecule basis, which provides much richer information about chemical dynamics than traditional ensemble-averaged experiments but also raises many new statistical challenges. The paper provides the first likelihood-based statistical analysis of the single-molecule fluorescence lifetime experiment designed to probe the conformational dynamics of a single deoxyribonucleic acid (DNA) hairpin molecule. The conformational change is initially treated as a continuous time two-state Markov chain, which is not observable and must be inferred from changes in photon emissions. This model is further complicated by unobserved molecular Brownian diffusions. Beyond the simple two-state model, a competing model that models the energy barrier between the two states of the DNA hairpin as an Ornstein–Uhlenbeck process has been suggested in the literature. We first derive the likelihood function of the simple two-state model and then generalize the method to handle complications such as unobserved molecular diffusions and the fluctuating energy barrier. The data augmentation technique and Markov chain Monte Carlo methods are developed to sample from the posterior distribution desired. The Bayes factor calculation and posterior estimates of relevant parameters indicate that the fluctuating barrier model fits the data better than the simple two-state model.     

Optimal Purchase and Transportation Cost Lot Sizing for a Single Item

A review of the literature indicates that the traditional approach for evaluating quantity discount offerings for purchased items has not adequately considered the effect that transportation costs may have on the optimal order quantity; despite the general fact that purchased materials must bear transportation charges. The transportation cost structure for less-than-truckload (LTL) shipments reflects sizable reductions in freight rates when the shipment size exceeds one of the nominal rate breakpoints. However, the shipper must also be aware of the opportunity to reduce total freight costs by artificially inflating the actual shipping weight to the next rate breakpoint, in order that a lower marginal tariff is achieved for the entire shipment. Such over-declared shipments result in an effective freight rate schedule that is characterized by constant fixed charge segments in addition to the nominal marginal rates. Over-declared shipments are economical when the shipment volume is less than the rate breakpoint, but greater than a cost indifference point between the two adjacent marginal rates. This paper presents a simple analytical procedure for finding the order quantity that minimizes total purchase costs which reflect both transportation economies and quantity discounts. After first solving for the series of indifference points that apply to a particular freight rate schedule, a total purchase cost expression is presented that properly accounts for the actual transportation cost structure. The optimal purchase order quantity will be one of the four following possibilities: (1) the valid economic order quantity (EOQ), QC; (2) a purchase price breakpoint in excess of QC; (3) a transportation rate breakpoint in excess of QC; and (4) a modified EOQ which provides an over-declared shipment in excess of QC. Finally, an algorithm which systematically explores these four possibilities is presented and illustrated with a numerical example.