Age and total and free prostate-specific antigen levels for predicting prostate volume in patients with benign prostatic hyperplasia

Objectives: To investigate the predictive values of free prostate-specific antigen (fPSA), total PSA (tPSA) and age on the prostate volume.

Methods: The data of 2148 patients with lower urinary tract symptoms were analyzed retrospectively. The patients who had transrectal ultrasonography guided 10 core biopsies owing to the findings obtained on digital rectal examination and presence of high PSA levels (PSA?=?2.5–10?ng/dl), and proven to have BPH histopathologically were included in the study. Age, tPSA, fPSA and the prostate volumes (PV) of the patients were noted.

Results: One thousand patients that fulfilled the inclusion criteria were included in the study. The PV of the patients were significantly correlated with age, tPSA and fPSA (p?r?=?0.307, p?r?=?0.382, p?r?=?0.296, respectively). On linear regression model, fPSA was found as a stronger predictive for PV (AUC?=?0.75, p?p?p?=?0.013).

Conclusions: Although tPSA is an important prognostic factor for predicting PV, the predictive value of fPSA is higher. PV can easily be predicted by using age, and serum tPSA and fPSA levels.     

A comparison study on modeling of clustered and overdispersed count data for multiple comparisons

Data collected in various scientific fields are count data. One way to analyze such data is to compare the individual levels of the factor treatment using multiple comparisons. However, the measured individuals are often clustered – e.g. according to litter or rearing. This must be considered when estimating the parameters by a repeated measurement model. In addition, ignoring the overdispersion to which count data is prone leads to an increase of the type one error rate. We carry out simulation studies using several different data settings and compare different multiple contrast tests with parameter estimates from generalized estimation equations and generalized linear mixed models in order to observe coverage and rejection probabilities. We generate overdispersed, clustered count data in small samples as can be observed in many biological settings. We have found that the generalized estimation equations outperform generalized linear mixed models if the variance-sandwich estimator is correctly specified. Furthermore, generalized linear mixed models show problems with the convergence rate under certain data settings, but there are model implementations with lower implications exists. Finally, we use an example of genetic data to demonstrate the application of the multiple contrast test and the problems of ignoring strong overdispersion.     

Variance estimation based on blocked 3×2 cross-validation in high-dimensional linear regression

In high-dimensional linear regression, the dimension of variables is always greater than the sample size. In this situation, the traditional variance estimation technique based on ordinary least squares constantly exhibits a high bias even under sparsity assumption. One of the major reasons is the high spurious correlation between unobserved realized noise and several predictors. To alleviate this problem, a refitted cross-validation (RCV) method has been proposed in the literature. However, for a complicated model, the RCV exhibits a lower probability that the selected model includes the true model in case of finite samples. This phenomenon may easily result in a large bias of variance estimation. Thus, a model selection method based on the ranks of the frequency of occurrences in six votes from a blocked 3×2 cross-validation is proposed in this study. The proposed method has a considerably larger probability of including the true model in practice than the RCV method. The variance estimation obtained using the model selected by the proposed method also shows a lower bias and a smaller variance. Furthermore, theoretical analysis proves the asymptotic normality property of the proposed variance estimation.     

基于波动持续性的最优组合构建与分散化研究

构建恰当资产组合来减少风险, 是投资组合理论研究的重要目标.由于金融时间序列的波动往往会伴随着持续性特征, 该种特性会增大组合未来收益的风险.本文通过构建随机波动模型序列持续性最优投资组合模型, 以降低金融资产波动的持续性特征对组合收益波动的影响;并通过研究其分散化水平, 考察该投资组合构建方法的有效性与稳健性.研究发现:与均值方差的组合模型相比较, 序列持续性组合的风险分散化水平更好.此研究在资产组合选择方面, 具有较为重要的理论价值及实践意义.     

一类稀疏投资组合双层参数估计模型及其应用

带基约束的投资组合问题是近年来投资组合领域的热点问题,但是参数不确定性直接影响了模型的效果。带基约束的投资组合问题所涉及的参数不仅包括以往研究认为非常重要的预期收益率,还包括控制投资组合规模的稀疏度,尤其是最优稀疏度估计方面的专门研究还十分匮乏。为了使带基约束的投资组合模型更好地为投资决策服务,本文从投资者效用出发,用双层规划的思想构建了带基约束的投资组合双层参数估计模型。然后根据模型的特点,设计了无导数优化算法框架,并基于ADMM对算法子问题进行求解。本文实验针对真实的市场数据给出了预期收益率和最优稀疏度的估计,接着通过与等权重策略和含上下界约束的均值-方差模型进行比较,说明了模型及算法的有效性和实用性。最后,将本文提出的双层参数估计模型推广到了更一般的形式。     

Sixty years of change in Tibetan fertility: An assessment

Existing knowledge of Tibetan historical population development is mostly based on ‘best-guess’ estimates and is heavily politicized. Using census data, I reconstruct the development of Tibetan fertility in China since the 1940s, with the objective of providing an independent assessment that can be used as benchmark for future studies and debates on Tibetan demography. Following major social and economic transformations starting in the 1950s, Tibetan fertility unexpectedly increased from the late 1950s to the late 1960s. As noted in several existing studies, Tibetan fertility in China then declined swiftly from the early 1980s onwards and has now reached values close to replacement level. Focusing on the 1950–70 period, I examine factors that contributed to shaping the Tibetan fertility increase in more detail. This confirms that changes in nuptiality and disease-related infertility both played a role in pushing up fertility rates among Tibetan women in China.     

Two-queue polling systems with switching policy based on the queue that is not being served

We study a system of two non-identical and separate M/M/1/? queues with capacities (buffers) C₁ < ∞ and C₂ = ∞, respectively, served by a single server that alternates between the queues. The server’s switching policy is threshold-based, and, in contrast to other threshold models, is determined by the state of the queue that is not being served. That is, when neither queue is empty while the server attends Q_i (i = 1, 2), the server switches to the other queue as soon as the latter reaches its threshold. When a served queue becomes empty we consider two switching scenarios: (i) Work-Conserving, and (ii) Non-Work-Conserving. We analyze the two scenarios using Matrix Geometric methods and obtain explicitly the rate matrix R, where its entries are given in terms of the roots of the determinants of two underlying matrices. Numerical examples are presented and extreme cases are investigated.     

Robust tests for the common principal components model

When dealing with several populations, the common principal components (CPC) model assumes equal principal axes but different variances along them. In this paper, a robust log-likelihood ratio statistic allowing to test the null hypothesis of a CPC model versus no restrictions on the scatter matrices is introduced. The proposal plugs into the classical log-likelihood ratio statistic robust scatter estimators. Using the same idea, a robust log-likelihood ratio and a robust Wald-type statistic for testing proportionality against a CPC model are considered. Their asymptotic distributions under the null hypothesis and their partial influence functions are derived. A small simulation study allows to compare the behavior of the classical and robust tests, under normal and contaminated data.     

Robust nonparametric estimation with missing data

In this paper, under a nonparametric regression model, we introduce two families of robust procedures to estimate the regression function when missing data occur in the response. The first proposal is based on a local M$M$-functional applied to the conditional distribution function estimate adapted to the presence of missing data. The second proposal imputes the missing responses using the local M$M$-smoother based on the observed sample and then estimates the regression function with the completed sample. We show that the robust procedures considered are consistent and asymptotically normally distributed. A robust procedure to select the smoothing parameter is also discussed.     

Conditional variance estimation in heteroscedastic regression models

First, we propose a new method for estimating the conditional variance in heteroscedasticity regression models. For heavy tailed innovations, this method is in general more efficient than either of the local linear and local likelihood estimators. Secondly, we apply a variance reduction technique to improve the inference for the conditional variance. The proposed methods are investigated through their asymptotic distributions and numerical performances.