Estimation of gene/haplotype frequencies in genetic marker systems based on phenotype data

Two equivalent methods (gene counting and maximum likelihood) for estimating gene frequencies in a general genetic marker system based on observed phenotype data are derived. Under the maximum likelihood approach, an expression is given for the estimated covariance matrix from which estimated standard errors of the estimators can be found. In addition, consideration is given to the problem of estimating gene frequencies when there are available several independent population data sets.     

Cumulants of random sum distributions

Consider a random variable S being the sum of a number N of independent and identically distributed random variables X_j (j = 1, 2, ...) where the number N is itself a non-negative integer-valued random variable independent of the X_j An explicit expression of the r-th cumulant of S is given in terms of the cumulants of N and X_j, Asymptotic properties of the distribution of S are also discussed.     

A class of distribution-free tests for two-way layout

In this article a class of distribution-free tests for the hypothesis of no row (treatment) effect in a two-way layout design, with several observations per cell, is proposed. The tests are based on U-statistics, constructed by considering minima of all possible subsamples of same size from each cell.The proposed class of tests is compared with the parametric test, Mack and Skillings test and Yate's test for two-way layout, in terms of Pitman ARE sense. It is seen that for the case of equal number of observations per cell, the proposed tests have better efficiency for exponential and uniform error distributions.     

Quadratic perturbation expansions of certain functions of eigenvalues and eigenvectors and their application to sensitivity analysis in multivariate methods

Tanaka (1988) lias derived the influence functions, which are equivalent to the perturbation expansions up to linear terms, of two functions of eigenvalues and eigenvectors of a real symmetric matrix, and applied them to principal component analysis. The present paper deals with the perturbation expansions up to quadratic terms of the same functions and discusses their application to sensitivity analysis in multivariate methods, in particular, principal component analysis and principal factor analysis. Numerical examples are given to show how the approximation improves with the quadratic terms.     

Gibbs sampling for marginal posterior expectations

In earlier work (Gelfand and Smith, 1990 and Gelfand et al, 1990) a sampling based approach using the Gibbs sampler was offered as a means for developing marginal posterior densities for a wide range of Bayesian problems several of which were previously inaccessible. Our purpose here is two-fold. First we flesh out the implementation of this approach for calculation of arbitrary expectations of interest. Secondly we offer comparison with perhaps the most prominent approach for calculating posterior expectations, analytic approximation involving application of the LaPlace method. Several illustrative examples are discussed as well. Clear advantages for the sampling based approach emerge.     

Evaluation of an analysis approach used to account for extra-variation in clustered categorical responses

This article presents the results of a simulation study investigating the performance of an approach developed by Miller and Landis (1991) for the analysis of clustered categorical responses. Evaluation of this “two-step” approach, which utilizes the method of moments to estimate the extra-variation pardmeters and subsequently incorporates these parameters into estimating equations for modelling the marginal expectations, is carried out in an experimental setting involving a comparison between two groups of observations. We assume that data for both groups are collected from each cluster and responses are measured on a three-point ordinal scale. The performance of the estimators used in both “steps” of the analysisis investigated and comparisons are made to an alternative analysismethod that ignores the clustering. The results indicate that in the chosen setting the test for a difference between groups generally operatbs at the nominal α=0.05 for 10 or more clusters and hasincreasing power with both an increasing number of clusters and an inrreasing treatment effect. These results provide a striking contrasc to those obtained from an improper analysis that ignores clustering.     

Comparison of estimators of the location parameter using pitman's closeness criterion

Necessary and sufficient conditions for a linear estimator to dominate another linear estimator of a location parameter under the Pitman's criterion of comparison are discussed. Consequently it is demonstrated that a linear biased estimator can not dominate a linear unbiased estimator under Pitman's criterion and that the sample mean is the Closest Linear Unbiased Estimator (CLUE). It is also shown that the ridge regression estimator with a known biasing constant can not dominate the ordinary least squares estimator. If an estimator δdominates an estimator δin the average loss sense then sufficient conditions are obtained under which δis also preferred over δunder Pitman's criterion. Further we obtain sufficient conditions under which preference under the Pitman's criterion will lead to preference under the mean squared error sense.     

Lot sensitive double sampling plan (lsdsp)

A sampling plan is derived for compliance testing providing consumer protection.