Statistical Properties of a Modified Accelerated Design for Phase I Cancer Clinical Trials

We consider the semiparametric profile likelihood inference for the distribution function under doubly censored data. For further developments of the statistical inference based on the profile likelihood ratio and alternative tools such as the score or Wald-type inference, we discuss the structures of the profile likelihood estimators and their derivatives included in the score function and the Fisher function of the profile likelihood, establishing the consistencies of their estimators.     

A note on robustness of D-optimal block designs for two-colour microarray experiments

Two-colour microarray experiments form an important tool in gene expression analysis. Due to the high risk of missing observations in microarray experiments, it is fundamental to concentrate not only on optimal designs but also on designs which are robust against missing observations. As an extension of Latif et al. (2009), we define the optimal breakdown number for a collection of designs to describe the robustness, and we calculate the breakdown number for various D-optimal block designs. We show that, for certain values of the numbers of treatments and arrays, the designs which are D-optimal have the highest breakdown number. Our calculations use methods from graph theory.     

Maboo wirriya,be healthy: Community-directed development of an evidence-based diabetes prevention program for young Aboriginal people in a remote Australian town

Supporting healthy lifestyle behaviours is a key aspect of preventing type 2 diabetes which disproportionately affects disadvantaged groups from a younger age. Formative participatory research was undertaken to design a program for young Aboriginal people in a remote town in North West Australia with a high level of health needs and relatively few prevention initiatives. Focus groups and advisory discussions with Aboriginal community members were used to determine the nature of the program. The need for a comprehensive program was consistently expressed and limited healthy lifestyle knowledge and difficulties with healthy eating influenced by food environments were noted to be important. With guidance from the Derby Aboriginal Health Service, findings were integrated with previous international research evidence to develop a program tailored to local Aboriginal people aged 15–25 years and refine it after piloting. This 8-session program, ‘Maboo wirriya, be healthy’ involved an education component consistent with the US Diabetes Prevention Program and practical activities including group exercise. Changes to program structure and documentation were made after piloting for future use. The community-directed approach used in this study is vital to ensure relevance of localised chronic disease prevention programs in a range of settings.     

儿童社会情绪学习：Strong Kids系列课程介绍及启示

Strong Kids系列课程是儿童社会情绪学习的经典课程之一，包括5个相对独立的版本，具有扎实的理论基础，是一项方便、经济且见效快的短期预防干预项目，能有效地预防和减少儿童的情绪行为障碍，提升儿童的社会情绪能力。该课程的设计、内容及形式等都值得为他人所借鉴。为此，笔者通过对Strong Kids系列课程的理论基础、主要内容及应用的阐述，探讨该课程的优势及对我国儿童社会情绪学习课程开发与实施的启示。     

CO2气体冷却器性能测试实验台设计

为了对CO2气体冷却器进行系统全面的性能分析,根据CO2制冷剂在亚临界区和超临界区的换热特性,以第二制冷剂量热器法和水冷气体冷却法为理论基础,结合企业实际测试需求研制了能够全面测试CO2气体冷却器性能的实验台。其可测试的换热量范围是1.6~32.0 kW,测量精度高。实际选用了一个气体冷却器做验证,结果显示2种测量方法的偏差小于4%,满足企业验收标准。此实验台的设计可为相关性能测试实验台的研究提供借鉴。     

Ability of Experience Design Elements to Elicit Emotions and Loyalty Behaviors

Experience design, an approach to create emotional connection with guests or customers through careful planning of tangible and intangible service elements, has gained popularity in many hospitality and retail businesses. With ever‐increasing competition, service providers seek to develop loyalty by aggressively designing, continuously innovating, and managing their customer experiences. This article explores the relationship between different service elements designed to create enhanced experience and customer loyalty. In addition, it looks at emotional responses as mediating factors between the physical and relational elements and loyalty behaviors. A model is proposed and tested with a VIP hospitality tent for an internationally renowned touring circus. Results of the study indicate that while a few design elements directly affect loyalty behavior, the relationship between most design elements and loyalty behavior is strongly mediated by eliciting certain types of emotional behavior. This connection has implications for the focus of service managers' efforts in different environments.     

数字经济、空间效应与全要素生产率

当前,数字经济蓬勃发展,已成为经济增长的新动能。本文从数字产业化与产业数字化 两个维度,采用主成分分析法构建了数字经济发展水平的指标体系,并利用2004-2017年我国省际面板 数据,在克服内生性问题的基础上,实证分析了数字经济发展对全要素生产率的影响。研究发现,数字 经济发展显著促进了全要素生产率的提升。但较之高生产率地区和东部地区,数字经济发展对低生产率地区和中西部地区全要素生产率的提升作用更大。就机制而言,人力资本投资与产业结构升级是数 字经济影响全要素生产率的两个渠道。进一步的空间计量分析表明,数字经济发展不仅会提升本地区 的全要素生产率,还存在显著的空间溢出效应,有助于提升邻近地区的全要素生产率。本文的研究为评估数字经济发展的影响效果提供了数据支撑和分析视角,也为探寻全要素生产率的提升路径提供了政策参考。     

An Exploratory Analysis of the Value of the Skills of IT Personnel: Their Relationship to IS Infrastructure and Competitive Advantage

Determining and assessing the requisite skills of information technology (IT) personnel have become critical as the value of IT has risen in modern organizations. In addition to technical skills traditionally expected of IT personnel, softer skills like managerial, business, and interpersonal skills have been increasingly cited in previous studies as mandatory for these employees. This paper uses a typology of IT personnel skills—technology management skills, business functional skills, interpersonal skills, and technical skills—and investigates their relationships to two information systems (IS) success variables, IS infrastructure flexibility and the competitive advantage provided by IS. The study investigates these relationships using the perceptions of chief information officers (CIOs) from mostly Fortune 2000 companies. The contributions of this study are: IT personnel skills do affect IS success, technical skills are viewed as the most important skill set in affecting IS infrastructure flexibility and competitive advantage, and modularity is viewed as more valuable to competitive advantage than integration. Several explanations are offered for the lack of positive relationships between the softer IT personnel skills and the dimensions of IS success used in this study.     

生态哲学--产品生态设计的哲学基础和理论指导

生态哲学研究人与自然相互作用的基本问题.生态哲学为人与自然、人与社会的综合优化发展提供了一般的方法论,也为工业设计的实践与发展提供了思路和原则.产品生态设计是生态学与工业设计相结合的产物,而马克思主义的生态哲学思想则为此提供了重要的理论指导.