A PROBLEM IN ASCERTAINMENT

In studies of disease inheritance, it is more convenient to collect family data by first locating an affected individual and then enquiring about the status of his or her relatives. Although the different categories of children classified by disease, sex, and other covariates may have a particular multinomial distribution among families of a given size, the numbers as ascertained do not have the same distribution because of unequal probabilities of selection of families. The introduction of weighted distributions to correct for ascertainment bias in the estimation of parameters in the classical segregation model can be traced to Fisher in 1934. This theory was presented in a general formulation by C. R. Rao at the First International Symposium on Classical and Contagious Distributions in 1963. Further expansion on the topic was given by C. R. Rao in the ISI Centenary Volume published in 1985. The effects of different two-phase sampling designs on the estimation of parameters in the classical segregation model are examined. An approximation to the classical segregation likelihood model is found to produce results close to those of the exact likelihood function in Monte Carlo simulations for a balanced two-phase design. This has implications for more complex models in which the computation of the exact likelihood is prohibitive, such as for the enhancement of a typical survey sampling plan designed initially for linkage analysis but then used retroactively for a combined segregation and linkage analysis.     

Two tests for sequential detection of a change-point in a nonlinear model

In this paper, two tests, based on weighted CUSUM of the least squares residuals, are studied to detect in real time a change-point in a nonlinear model. A first test statistic is proposed by extension of a method already used in the literature but for the linear models. It is tested under the null hypothesis, at each sequential observation, that there is no change in the model against a change presence. The asymptotic distribution of the test statistic under the null hypothesis is given and its convergence in probability to infinity is proved when a change occurs. These results will allow to build an asymptotic critical region. Next, in order to decrease the type I error probability, a bootstrapped critical value is proposed and a modified test is studied in a similar way. A generalization of the Hájek–Rényi inequality is established.     

The Modeling and Seasonal Adjustment of Weekly Observations

Several important economic time series are recorded on a particular day every week. Seasonal adjustment of such series is difficult because the number of weeks varies between 52 and 53 and the position of the recording day changes from year to year. In addition certain festivals, most notably Easter, take place at different times according to the year. This article presents a solution to problems of this kind by setting up a structural time series model that allows the seasonal pattern to evolve over time and enables trend extraction and seasonal adjustment to be carried out by means of state-space filtering and smoothing algorithms. The method is illustrated with a Bank of England series on the money supply.     

A Multivariate Synthetic Control Chart for Monitoring the Process Mean Vector of Skewed Populations Using Weighted Standard Deviations

This article proposes a multivariate synthetic control chart for skewed populations based on the weighted standard deviation method. The proposed chart incorporates the weighted standard deviation method into the standard multivariate synthetic control chart. The standard multivariate synthetic chart consists of the Hotelling's T ² chart and the conforming run length chart. The weighted standard deviation method adjusts the variance–covariance matrix of the quality characteristics and approximates the probability density function using several multivariate normal distributions. The proposed chart reduces to the standard multivariate synthetic chart when the underlying distribution is symmetric. In general, the simulation results show that the proposed chart performs better than the existing multivariate charts for skewed populations and the standard T ² chart, in terms of false alarm rates as well as moderate and large mean shift detection rates based on the various degrees of skewnesses.     

Determining Optimal Number of Samples for Constructing Multivariate Control Charts

Normally, an average run length (ARL) is used as a measure for evaluating the detecting performance of a multivariate control chart. This has a direct impact on the false alarm cost in Phase II. In this article, we first conduct a simulation study to calculate both in-control and out-of-control ARLs under various combinations of process shifts and number of samples. Then, a trade-off analysis between sampling inspection and false alarm costs is performed. Both the simulation results and trade-off analysis suggest that the optimal number of samples for constructing a multivariate control chart in Phase I can be determined.     

Parameter Estimation Through Weighted Least-Squares Rank Regression with Specific Reference to the Weibull and Gumbel Distributions

Probability plots are often used to estimate the parameters of distributions. Using large sample properties of the empirical distribution function and order statistics, weights to stabilize the variance in order to perform weighted least squares regression are derived. Weighted least squares regression is then applied to the estimation of the parameters of the Weibull, and the Gumbel distribution. The weights are independent of the parameters of the distributions considered. Monte Carlo simulation shows that the weighted least-squares estimators outperform the usual least-squares estimators totally, especially in small samples.     

Detection of Multiple Outbreaks Using Spatio-Temporal EWMA-Ordered Statistics

Spatio-temporal surveillance methods for detecting outbreaks of disease are fairly common in the literature with the scan statistic setting the benchmark. If the shape and size of the outbreaks are known in advance, then the scan approach can be designed to efficiently detect these, however, this is seldom true. Therefore we want to devise plans that are efficient at detecting a number of outbreaks that vary in size and shape. This paper examines plans which use the exponential weighted moving average statistic to build temporal memory into plans and tries to develop robust plans for detecting outbreaks of unknown shapes and sizes.     

Zone control charts with estimated parameters for detecting prespecified changes in linear profiles

ABSTRACT

In profile monitoring, control charts are proposed to detect unanticipated changes, and it is usually assumed that the in-control parameters are known. However, due to the characteristics of a system or process, the prespecified changes would appear in the process. Moreover, in most applications, the in-control parameters are usually unknown. To overcome these issues, we develop the zone control charts with estimated parameters to detect small shifts of these prespecified changes. The effects of estimation error have been investigated on the performance of the proposed charts. To account for the practitioner-to-practitioner variability, the expected average run length (ARL) and the standard deviation of the average run length (SDARL) is used as the performance metrics. Our results show that the estimation error results in the significant variation in the ARL distribution. Furthermore, in order to adequately reduce the variability, more phase I samples are required in terms of the SDARL metric than that in terms of the expected ARL metric. In addition, more observations on each sampled profile are suggested to improve the charts' performance, especially for small phase I sample sizes. Finally, an illustrative example is given to show the performance of the proposed zone control charts.     

Distribution-Free Quality Control Charts Based on Signed-Rank-Like Statistics

In this article we propose three distribution-free (or nonparametric) statistical quality control charts for monitoring a process center when an in-control target center is not specified. These charts are of the Shewhart-type, the exponentially moving average-type, and the cumulative sum-type. The constructions of the proposed charts require the availability of an initial reference sample taken when the process was operating in-control to calculate an estimator for the unknown in-control target process center. This estimated center is then used in the calculation of signed-rank-like statistics based on grouped observations taken periodically from the process output. As long as the in-control process underlying distribution is continuous and symmetric, the proposed charts have a constant in-control average run length and a constant false alarm rate irrespective of the process underlying distribution. Other advantages of the proposed distribution-free charts include their robustness against outliers and their superior efficiency over the traditional normal-based control charts when applied to processes with moderate- or heavy-tailed underlying distributions, such as the double exponential or the Cauchy distributions.