27类蛋白质折叠子的识别及其位点的统计分析

从蛋白质的氨基酸序列出发,采用全体分类的分类策略识别27类折叠子.当使用5种矩阵打分的方法识别27类折叠子时,预测结果并不理想,进一步使用了以矩阵打分方法得到的分值及氨基酸的二肽组分共同作为参数的离散增量算法,取得了较好预测效果.总的预测成功率达到了45.43%.     

A counterexample to Beder's conjectures about Hadamard matrices

In this note we provide a counterexample which resolves conjectures about Hadamard matrices made in this journal. Beder [1998. Conjectures about Hadamard matrices. Journal of Statistical Planning and Inference 72, 7–14] conjectured that if H$\mathit{H}$ is a maximal m×n$m\times n$ row-Hadamard matrix then m is a multiple of 4; and that if n   is a power of 2 then every row-Hadamard matrix can be extended to a Hadamard matrix. Using binary integer programming we obtain a maximal 13×32$13\times 32$ row-Hadamard matrix, which disproves both conjectures. Additionally for n being a multiple of 4 up to 64, we tabulate values of m   for which we have found a maximal row-Hadamard matrix. Based on the tabulated results we conjecture that a m×n$m\times n$ row-Hadamard matrix with m?n-7$m?n-7$ can be extended to a Hadamard matrix.     

“Double-dose” English as a strategy for improving adolescent literacy: Total effect and mediated effect through classroom peer ability change

“Double-dose” coursework has become an increasingly popular strategy to assist low-performing students succeed in academic coursework. Chicago implemented a “double-dose” English policy in 2003. This policy not only provided additional instructional time to struggling readers, but also intensified skill-based sorting in English classes. I use policy-induced variation to infer the policy effect on students’ reading achievement and the effect mediated by classroom peer ability change. Results show very weak, but positive effects of taking double-dose English for students with average skills. However, potential benefits of doubled instructional time are likely to be offset by negative effects of declines in classroom peer ability. Students with very weak skills experienced minimal change in classroom peer ability, and two-period coursework is likely to benefit these students.     

The exponentiated reduced Kies distribution: Properties and applications

Here we consider an exponentiated version of the reduced Kies distribution and discuss some of its properties. The parameters of the distribution are estimated by the method of maximum likelihood and illustrated with the help of certain real-life data sets. Asymptotic behavior of the maximum likelihood estimators of the parameters of the distribution is also studied by using certain simulated data sets.     

The Generalized Conditional Autoregressive Wishart Model for Multivariate Realized Volatility

It is well known that in finance variances and covariances of asset returns move together over time. Recently, much interest has been aroused by an approach involving the use of the realized covariance (RCOV) matrix constructed from high-frequency returns as the ex-post realization of the covariance matrix of low-frequency returns. For the analysis of dynamics of RCOV matrices, we propose the generalized conditional autoregressive Wishart (GCAW) model. Both the noncentrality matrix and scale matrix of the Wishart distribution are driven by the lagged values of RCOV matrices, and represent two different sources of dynamics, respectively. The GCAW is a generalization of the existing models, and accounts for symmetry and positive definiteness of RCOV matrices without imposing any parametric restriction. Some important properties such as conditional moments, unconditional moments, and stationarity are discussed. Empirical examples including sequences of daily RCOV matrices from the New York Stock Exchange illustrate that our model outperforms the existing models in terms of model fitting and forecasting.     

Bivariate,multivariate, and matrix variate normal characterizations: A brief survey II

The paper entitled “Bivariate and Multivariate Normal Characterizations: A Brief Survey,” by Hamedani, which was published in 1992, covered the published characterizations of bivariate and multivariate normal (MVN) distributions from 1941 to 1991. The present work is a follow-up to the 1991/1992 survey which includes not only characterizations of the bivariate and MVN distributions, but also characterizations of the matrix variate normal distribution, which have appeared from 1991/1992 to the present.     

Two-queue polling systems with switching policy based on the queue that is not being served

We study a system of two non-identical and separate M/M/1/? queues with capacities (buffers) C₁ < ∞ and C₂ = ∞, respectively, served by a single server that alternates between the queues. The server’s switching policy is threshold-based, and, in contrast to other threshold models, is determined by the state of the queue that is not being served. That is, when neither queue is empty while the server attends Q_i (i = 1, 2), the server switches to the other queue as soon as the latter reaches its threshold. When a served queue becomes empty we consider two switching scenarios: (i) Work-Conserving, and (ii) Non-Work-Conserving. We analyze the two scenarios using Matrix Geometric methods and obtain explicitly the rate matrix R, where its entries are given in terms of the roots of the determinants of two underlying matrices. Numerical examples are presented and extreme cases are investigated.     

Extended scaled prediction variance optimality for modified central composite design

Robust parameter designs (RPDs) enable the experimenter to discover how to modify the design of the product to minimize the effect due to variation from noise sources. The aim of this article is to show how this amount of work can be reduced under modified central composite design (MCCD). We propose a measure of extended scaled prediction variance (ESPV) for evaluation of RPDs on MCCD. Using these measures, we show that we can check the error or bias associated with estimating the model parameters and suggest the values of α recommended for MCCS under minimum ESPV.     

A Comparison of Correlation Structure Selection Penalties for Generalized Estimating Equations

Correlated data are commonly analyzed using models constructed using population-averaged generalized estimating equations (GEEs). The specification of a population-averaged GEE model includes selection of a structure describing the correlation of repeated measures. Accurate specification of this structure can improve efficiency, whereas the finite-sample estimation of nuisance correlation parameters can inflate the variances of regression parameter estimates. Therefore, correlation structure selection criteria should penalize, or account for, correlation parameter estimation. In this article, we compare recently proposed penalties in terms of their impacts on correlation structure selection and regression parameter estimation, and give practical considerations for data analysts. Supplementary materials for this article are available online.     

Continuity of f-projections and applications to the iterative proportional fitting procedure*

This paper proves continuity of f-projections and the continuous dependence of the limit matrix of the iterative proportional fitting procedure (IPF procedure) on the given matrix as well as the given marginals under certain regularity constraints. For finite spaces, the concept of f-projections of finite measures on a compact and convex set is introduced and continuity of f-projections is proven. This result is applied to the IPF procedure. Given a nonnegative matrix as well as row and column marginals the IPF procedure generates a sequence of matrices, called the IPF sequence, by alternately fitting rows and columns to match their respective marginals. The procedure is equivalent to cyclic f-projections. If the IPF sequence converges, the application of the continuity of f-projections yields the continuous dependence of the limit matrix on the given matrix. By generalized convex programming and under some constraints, it is shown that the limit matrix of the IPF sequence continuously depends not only on the given matrix but also on the marginals.