A comparative study of confidence intervals to assess biosimilarity from analytical data

Assessment of analytical similarity of tier 1 quality attributes is based on a set of hypotheses that tests the mean difference of reference and test products against a margin adjusted for standard deviation of the reference product. Thus, proper assessment of the biosimilarity hypothesis requires statistical tests that account for the uncertainty associated with the estimations of the mean differences and the standard deviation of the reference product. Recently, a linear reformulation of the biosimilarity hypothesis has been proposed, which facilitates development and implementation of statistical tests. These statistical tests account for the uncertainty in the estimation process of all the unknown parameters. In this paper, we survey methods for constructing confidence intervals for testing the linearized reformulation of the biosimilarity hypothesis and also compare the performance of the methods. We discuss test procedures using confidence intervals to make possible comparison among recently developed methods as well as other previously developed methods that have not been applied for demonstrating analytical similarity. A computer simulation study was conducted to compare the performance of the methods based on the ability to maintain the test size and power, as well as computational complexity. We demonstrate the methods using two example applications. At the end, we make recommendations concerning the use of the methods.     

The impact of the European Youth Guarantee on active labour market policies: A convergence analysis

The European Union’s (EU) Youth Guarantee aims to improve the labour market situation of young people. Rather than prescribing a uniform policy model, it acknowledges that supportive measures need to align with national, regional and local circumstances. It thus seeks to promote mutual policy learning through the open method of coordination. As an innovative measure, the EU has deployed funding programmes to support the domestic measures related to the Youth Guarantee. We therefore examined in this study whether this mix of recommendations and financial incentives has entailed a convergence of member state policies. Our analysis of policy outputs for the period 2007?2014 yields a mixed empirical picture. There is catching‐up convergence regarding policies’ sectoral coverage but increasing divergence concerning the number of adopted policy instruments. The first two years of financial incentives did not produce any effect on enhancing policy experimentation among less active member states. We offer an optimistic and a pessimistic interpretation of these findings.     

基于Mo-RVIKOR的混合多属性决策方法

针对复杂性和不确定性多属性决策问题,考虑定量和定性融合的属性形式,提出了模块化随机多准则妥协解排序法（Modular Random VlseKriterijumska Opti-mizacija I Kompromisno Resenje,Mo-RVIKOR）,该方法无需将信息统一,就能处理多种信息形式存在的多属性决策问题。采用精确数、随机变量处理定量评价信息,用概率语义术语集处理定性评价信息;通过改进离差最大化法确定属性权重;根据Mo-RVIKOR对决策对象进行排序;最后以某公司C2B定制化服务质量评测项目为例,验证了所提方法的有效性。     

基于雨课堂的电工电子学混合式智慧教学方法研究

《电工电子学》是高等学校针对非电类工科专业开设的一门有关电工、电子技术的重要专业基础课。针对《电工电子学》传统理论教学空洞乏味、师生互动不足、学生学习兴趣不足等问题,在《电工电子学》课程教学中引入雨课堂智慧教学工具,论述了雨课堂从课前、课上和课后三个方面实践的特点和使用方法,实践表明,基于PPT和微信的雨课堂混合传统教学的教学方法可以实现师生实时线上互动,建立多元化科学评价机制,激发学生学习主动性,活跃课堂气氛,提高学生学习积极性,改善本门课程的教学效果。     

关于英雄烈士名誉保护的民法规范的适用研究 ——以民法总则第185条为视角

英雄烈士是民族精神的载体,是中华民族文化自信的重要来源,同时英雄烈士的名誉也关乎社会公共利益,是社会公共 利益的重要组成部分,全社会应有尊重和保护英雄烈士名誉的义务。《民法总则》第185条首次特别强调对英雄烈士名誉的法 律保护。在此基础上,英雄应解释为近代以来为国家、民族和社会利益做出显著成绩和突出贡献并已身故的人员,烈士的认定 依现有的评定标准。应明确界定以歪曲、丑化、诋毁、否定的方式侵害英雄烈士名誉的行为。在英雄烈士近亲属可提起诉讼的 基础上,赋予民政部门和人民检察院起诉的权利。     

DNS分光光度法测定牛奶中总糖含量的研究

建立了3,5-二硝基水杨酸分光光度法(DNS分光光度法)测定牛奶中总糖含量的方法,并与国标法(直接滴定法)进行比较.结果显示,DNS分光光度法测定结果的准确度与直接滴定法无明显差异.该法操作简单,试剂消耗体积少,稳定性较高,平均回收率为96%~103%.     

运用任务教学法激发学生英语学习动机

调查发现,缺乏学习动机是影响体育、艺术专业学生英语水平的主要因素之一。经过两种教学法在实际教学中的比较,证明了任务教学法比传统教学法更有助于培养学习兴趣、激发学习动机和提高学生总体的英语水平。     

一种考虑风险的项目活动持续时间的估算方法

在介绍PERT网络模型基础上 ,从影响项目工期的风险因素出发 ,分析风险因素对项目活动的影响 ,提出了一种新的项目活动持续时间的估算方法 ,通过多次模拟确定项目持续时间分布和期望工期 ,并可找出影响项目工期最大的因素。     

基于熵值法的东陇海产业带区域发展能力评价与建设策略

以市区和县域为研究单元,从经济发展推动力、社会发展支撑力、资源环境承载力三个方面构建区域发展能力指标体系.采用熵值法进行量化分析并进行发展能力评价.从省域层面看,该区域发展能力明显弱于省平均水平;从区域内部看,发展能力差距明显,综合发展能力优势集中在东陇海产业带的双核及轴线上.在区域发展能力评价的基础上,提出区域发展能力的建设策略:整合空间结构,深化区域分工,完善基础设施,涵养资源环境.