Three-group ROC predictive analysis for ordinal outcomes

Measuring the accuracy of diagnostic tests is crucial in many application areas including medicine, machine learning, and credit scoring. The receiver operating characteristic (ROC) surface is a useful tool to assess the ability of a diagnostic test to discriminate among three-ordered classes or groups. In this article, nonparametric predictive inference (NPI) for three-group ROC analysis for ordinal outcomes is presented. NPI is a frequentist statistical method that is explicitly aimed at using few modeling assumptions, enabled through the use of lower and upper probabilities to quantify uncertainty. This article also includes results on the volumes under the ROC surfaces and consideration of the choice of decision thresholds for the diagnosis. Two examples are provided to illustrate our method.     

Generalized empirical likelihood inference in partially linear model for longitudinal data with missing response variables and error-prone covariates

In this article, we consider statistical inference for longitudinal partial linear models when the response variable is sometimes missing with missingness probability depending on the covariate that is measured with error. A generalized empirical likelihood (GEL) method is proposed by combining correction attenuation and quadratic inference functions. The method that takes into consideration the correlation within groups is used to estimate the regression coefficients. Furthermore, residual-adjusted empirical likelihood (EL) is employed for estimating the baseline function so that undersmoothing is avoided. The empirical log-likelihood ratios are proven to be asymptotically Chi-squared, and the corresponding confidence regions for the parameters of interest are then constructed. Compared with methods based on NAs, the GEL does not require consistent estimators for the asymptotic variance and bias. The numerical study is conducted to compare the performance of the EL and the normal approximation-based method, and a real example is analysed.     

Adaptive multiple importance sampling for Gaussian processes

In applications of Gaussian processes (GPs) where quantification of uncertainty is a strict requirement, it is necessary to accurately characterize the posterior distribution over Gaussian process covariance parameters. This is normally done by means of standard Markov chain Monte Carlo (MCMC) algorithms, which require repeated expensive calculations involving the marginal likelihood. Motivated by the desire to avoid the inefficiencies of MCMC algorithms rejecting a considerable amount of expensive proposals, this paper develops an alternative inference framework based on adaptive multiple importance sampling (AMIS). In particular, this paper studies the application of AMIS for GPs in the case of a Gaussian likelihood, and proposes a novel pseudo-marginal-based AMIS algorithm for non-Gaussian likelihoods, where the marginal likelihood is unbiasedly estimated. The results suggest that the proposed framework outperforms MCMC-based inference of covariance parameters in a wide range of scenarios.     

Spatio‐temporal Ornstein–Uhlenbeck Processes: Theory,Simulation and Statistical Inference

Spatio‐temporal modelling is an increasingly popular topic in Statistics. Our paper contributes to this line of research by developing the theory, simulation and inference for a spatio‐temporal Ornstein–Uhlenbeck process. We conduct detailed simulation studies and demonstrate the practical relevance of these processes in an empirical study of radiation anomaly data. Finally, we describe how predictions can be carried out in the Gaussian setting.     

An approximation to the convolution of gamma distributions

In general, the exact distribution of a convolution of independent gamma random variables is quite complicated and does not admit a closed form. Of all the distributions proposed, the gamma-series representation of Moschopoulos (1985 Moschopoulos, P. G. (1985). The distribution of the sum of independent gamma random variables. Annals of the Institute of Statistical Mathematics 37Part A:541–544. [Google Scholar]) is relatively simple to implement but for particular combinations of scale and/or shape parameters the computation of the weights of the series can result in complications with too much time consuming to allow a large-scale application. Recently, a compact random parameter representation of the convolution has been proposed by Vellaisamy and Upadhye (2009 Vellaisamy, P., Upadhye, N. S. (2009). On the sums of compound negative binomial and gamma random variables. Journal of Applied Probability 46:272–283.[Crossref], [Web of Science ®] , [Google Scholar]) and it allows to give an exact interpretation to the weights of the series. They describe an infinite discrete probability distribution. This result suggested to approximate Moschopoulos’s expression looking for an approximating theoretical discrete distribution for the weights of the series. More precisely, we propose a general negative binomial distribution. The result is an “excellent” approximation, fast and simple to implement for any parameter combination.     

Comparison of methods for analyzing binary repeated measures data: A simulation-based study (comparison of methods for binary repeated measures)

In this study, some methods suggested for binary repeated measures, namely, Weighted Least Squares (WLS), Generalized Estimating Equations (GEE), and Generalized Linear Mixed Models (GLMM) are compared with respect to power, type 1 error, and properties of estimates. The results indicate that with adequate sample size, no missing data, the only covariate being time effect, and a relatively limited number of time points, the WLS method performs well. The GEE approach performs well only for large sample sizes. The GLMM method is satisfactory with respect to type I error, but its estimates have poorer properties than the other methods.     

Monotonic change point estimation of generalized linear model-based regression profiles

In this article, a maximum likelihood estimator is derived in the generalized linear model-based regression profiles under monotonic change in Phase II. The performance of the proposed estimator is comprehensively investigated through some special cases, and compared with estimators under step change and drift. The results show that the proposed estimator has better performance in small and medium shifts under different increasing changes. Finally, the applicability of the proposed estimator is illustrated using a real case.