Comparing diagnostic tests: test of hypothesis for likelihood ratios

Likelihood ratios (LRs) are used to characterize the efficiency of diagnostic tests. In this paper, we use the classical weighted least squares (CWLS) test procedure, which was originally used for testing the homogeneity of relative risks, for comparing the LRs of two or more binary diagnostic tests. We compare the performance of this method with the relative diagnostic likelihood ratio (rDLR) method and the diagnostic likelihood ratio regression (DLRReg) approach in terms of size and power, and we observe that the performances of CWLS and rDLR are the same when used to compare two diagnostic tests, while DLRReg method has higher type I error rates and powers. We also examine the performances of the CWLS and DLRReg methods for comparing three diagnostic tests in various sample size and prevalence combinations. On the basis of Monte Carlo simulations, we conclude that all of the tests are generally conservative and have low power, especially in settings of small sample size and low prevalence.     

Tests for generalized exponential laws based on the empirical Mellin transform

Recently, many standard families of distributions have been generalized by exponentiating their cumulative distribution function (CDF). In this paper, test statistics are constructed based on CDF–transformed observations and the corresponding moments of arbitrary positive order. Simulation results for generalized exponential distributions show that the proposed test compares well with standard methods based on the empirical distribution function.     

On partial linear additive isotonic regression

In this paper we discuss semiparametric additive isotonic regression models. We discuss the efficiency bound of the model and the least squares estimator under this model. We show that the ordinary least square estimator studied by Huang (2002) and Cheng (2009) for the semiparametric isotonic regression achieves the efficiency bound for the regular estimator when the true parameter belongs to the interior of the parameter space. We also show that the result by Cheng (2009) can be generalized to the case that the covariates are dependent on each other.     

Quantile regression and variable selection for the single-index model

In this paper, we propose a new full iteration estimation method for quantile regression (QR) of the single-index model (SIM). The asymptotic properties of the proposed estimator are derived. Furthermore, we propose a variable selection procedure for the QR of SIM by combining the estimation method with the adaptive LASSO penalized method to get sparse estimation of the index parameter. The oracle properties of the variable selection method are established. Simulations with various non-normal errors are conducted to demonstrate the finite sample performance of the estimation method and the variable selection procedure. Furthermore, we illustrate the proposed method by analyzing a real data set.     

Local estimation for varying-coefficient models with longitudinal data

Varying-coefficient models are very useful for longitudinal data analysis. In this paper, we focus on varying-coefficient models for longitudinal data. We develop a new estimation procedure using Cholesky decomposition and profile least squares techniques. Asymptotic normality for the proposed estimators of varying-coefficient functions has been established. Monte Carlo simulation studies show excellent finite-sample performance. We illustrate our methods with a real data example.     

On the existence of maximum likelihood estimates for weighted logistic regression

The problems of existence and uniqueness of maximum likelihood estimates for logistic regression were completely solved by Silvapulle in 1981 and Albert and Anderson in 1984. In this paper, we extend the well-known results by Silvapulle and by Albert and Anderson to weighted logistic regression. We analytically prove the equivalence between the overlap condition used by Albert and Anderson and that used by Silvapulle. We show that the maximum likelihood estimate of weighted logistic regression does not exist if there is a complete separation or a quasicomplete separation of the data points, and exists and is unique if there is an overlap of data points. Our proofs and results for weighted logistic apply to unweighted logistic regression.     

Bayesian analysis of multivariate stochastic volatility with skew return distribution

Multivariate stochastic volatility models with skew distributions are proposed. Exploiting Cholesky stochastic volatility modeling, univariate stochastic volatility processes with leverage effect and generalized hyperbolic skew t-distributions are embedded to multivariate analysis with time-varying correlations. Bayesian modeling allows this approach to provide parsimonious skew structure and to easily scale up for high-dimensional problem. Analyses of daily stock returns are illustrated. Empirical results show that the time-varying correlations and the sparse skew structure contribute to improved prediction performance and Value-at-Risk forecasts.     

Robust sparse regression and tuning parameter selection via the efficient bootstrap information criteria

There is currently much discussion about lasso-type regularized regression which is a useful tool for simultaneous estimation and variable selection. Although the lasso-type regularization has several advantages in regression modelling, owing to its sparsity, it suffers from outliers because of using penalized least-squares methods. To overcome this issue, we propose a robust lasso-type estimation procedure that uses the robust criteria as the loss function, imposing L₁-type penalty called the elastic net. We also introduce to use the efficient bootstrap information criteria for choosing optimal regularization parameters and a constant in outlier detection. Simulation studies and real data analysis are given to examine the efficiency of the proposed robust sparse regression modelling. We observe that our modelling strategy performs well in the presence of outliers.     

Generalizing the standardized hazard ratio to multivariate proportional hazards regression,with an application to clinical~genomic studies

The standardized hazard ratio for univariate proportional hazards regression is generalized as a scalar to multivariate proportional hazards regression. Estimators of the standardized log hazard ratio are developed, with corrections for bias and for regression to the mean in high-dimensional analyses. Tests of point and interval null hypotheses and confidence intervals are constructed. Cohort sampling study designs, commonly used in prospective–retrospective clinical genomic studies, are accommodated.     

Inferences on functions of Pareto parameters with application to income inequality measures

The Theil, Pietra, Éltetö and Frigyes measures of income inequality associated with the Pareto distribution function are expressed in terms of parameters defining the Pareto distribution. Inference procedures based on the generalized variable method, the large sample method, and the Bayesian method for testing of, and constructing confidence interval for, these measures are discussed. The results of Monte Carlo study are used to compare the performance of the suggested inference procedures from a population characterized by a Pareto distribution.