Cytometry inference through adaptive atomic deconvolution

In this paper, we consider a statistical estimation problem known as atomic deconvolution. Introduced in reliability, this model has a direct application when considering biological data produced by flow cytometers. From a statistical point of view, we aim at inferring the percentage of cells expressing the selected molecule and the probability distribution function associated with its fluorescence emission. We propose here an adaptive estimation procedure based on a previous deconvolution procedure introduced by Es, Gugushvili, and Spreij [(2008), ‘Deconvolution for an atomic distribution’, Electronic Journal of Statistics, 2, 265–297] and Gugushvili, Es, and Spreij [(2011), ‘Deconvolution for an atomic distribution: rates of convergence’, Journal of Nonparametric Statistics, 23, 1003–1029]. For both estimating the mixing parameter and the mixing density automatically, we use the Lepskii method based on the optimal choice of a bandwidth using a bias-variance decomposition. We then derive some convergence rates that are shown to be minimax optimal (up to some log terms) in Sobolev classes. Finally, we apply our algorithm on the simulated and real biological data.     

On the asymptotic normality of the R-estimators of the slope parameters of simple linear regression models with associated errors

ABSTRACT

The purpose of this paper is to prove, under mild conditions, the asymptotic normality of the rank estimator of the slope parameter of a simple linear regression model with stationary associated errors. This result follows from a uniform linearity property for linear rank statistics that we establish under general conditions on the dependence of the errors. We prove also a tightness criterion for weighted empirical process constructed from associated triangular arrays. This criterion is needed for the proofs which are based on that of Koul [Behavior of robust estimators in the regression model with dependent errors. Ann Stat. 1977;5(4):681–699] and of Louhichi [Louhichi S. Weak convergence for empirical processes of associated sequences. Ann Inst Henri Poincaré Probabilités Statist. 2000;36(5):547–567].     

Estimation of parameters of inverse Weibull distribution and application to multi-component stress-strength model

The problem of estimation of the parameters of two-parameter inverse Weibull distributions has been considered. We establish existence and uniqueness of the maximum likelihood estimators of the scale and shape parameters. We derive Bayes estimators of the parameters under the entropy loss function. Hierarchical Bayes estimator, equivariant estimator and a class of minimax estimators are derived when shape parameter is known. Ordered Bayes estimators using information about second population are also derived. We investigate the reliability of multi-component stress-strength model using classical and Bayesian approaches. Risk comparison of the classical and Bayes estimators is done using Monte Carlo simulations. Applications of the proposed estimators are shown using real data sets.     

Small area estimation for longitudinal surveys

Over the last few years many studies have been carried out in Italy to identify reliable small area labour force indicators. Considering the rotated sample design of the Italian Labour Force Survey, the aim of this work is to derive a small area estimator which borrows strength from individual temporal correlation, as well as from related areas. Two small area estimators are derived as extensions of an estimation strategies proposed by Fuller (1990) for partial overlap samples. A simulation study is carried out to evaluate the gain in efficiency provided by our solutions. Results obtained for different levels of autocorrelation between repeated measurements on the same outcome and different population settings show that these estimators are always more reliable than the traditional composite one, and in some circumstances they are extremely advantageous.The present paper is financially supported by Murst-Cofin (2001) Lutilizzo di informazioni di tipo amministrativo nella stima per piccole aree e per sottoinsiemi della popolazione (National Coordinator Prof. Carlo Filippucci).     

Estimating the fundamental frequency of a periodic function

In this paper we consider the problem of estimation of the fundamental frequency of a periodic function, which has several applications in Speech Signal Processing. The problem was originally proposed by Hannan (1974) and later on Quinn and Thomson (1991) provided an estimation procedure of the unknown parameters. It is observed that the estimation procedure of Quinn and Thomson (1991) is quite involved numerically. In this paper we propose to use two simple estimators and it is observed that their performance are quite satisfactory. Asymptotic properties of the proposed estimators are obtained. The large sample properties of the estimators are compared theoretically. We present some simulation results to compare their small sample performance. One speech data is analyzed using this particular model.     

Merging data from multiple sources: pretest and shrinkage perspectives

In this article, we have developed asymptotic theory for the simultaneous estimation of the k means of arbitrary populations under the common mean hypothesis and further assuming that corresponding population variances are unknown and unequal. The unrestricted estimator, the Graybill-Deal-type restricted estimator, the preliminary test, and the Stein-type shrinkage estimators are suggested. A large sample test statistic is also proposed as a pretest for testing the common mean hypothesis. Under the sequence of local alternatives and squared error loss, we have compared the asymptotic properties of the estimators by means of asymptotic distributional quadratic bias and risk. Comprehensive Monte-Carlo simulation experiments were conducted to study the relative risk performance of the estimators with reference to the unrestricted estimator in finite samples. Two real-data examples are also furnished to illustrate the application of the suggested estimation strategies.     

Estimating a sensitive proportion through randomized response procedures based on auxiliary information

Randomized response techniques are widely employed in surveys dealing with sensitive questions to ensure interviewee anonymity and reduce nonrespondents rates and biased responses. Since Warner’s (J Am Stat Assoc 60:63–69, 1965) pioneering work, many ingenious devices have been suggested to increase respondent’s privacy protection and to better estimate the proportion of people, π _A , bearing a sensitive attribute. In spite of the massive use of auxiliary information in the estimation of non-sensitive parameters, very few attempts have been made to improve randomization strategy performance when auxiliary variables are available. Moving from Zaizai’s (Model Assist Stat Appl 1:125–130, 2006) recent work, in this paper we provide a class of estimators for π _A , for a generic randomization scheme, when the mean of a supplementary non-sensitive variable is known. The minimum attainable variance bound of the class is obtained and the best estimator is also identified. We prove that the best estimator acts as a regression-type estimator which is at least as efficient as the corresponding estimator evaluated without allowing for the auxiliary variable. The general results are then applied to Warner and Simmons’ model.     

Asymptotic distributions for the intervals estimators of the extremal index and the cluster-size probabilities

Under appropriate long range dependence conditions, the point process of exceedances of a stationary sequence weakly converges to a homogeneous compound Poisson point process. This limiting point process can be characterized by the extremal index and the cluster-size probabilities. In this paper we address the problem of estimating these quantities and we consider the intervals estimators introduced in Ferro and Segers [2003. Inference for clusters of extreme values. J. Roy. Statist. Soc. Ser. B 545–556] and in Ferro [2004. Statistical methods for clusters of extreme values. Ph.D. Thesis, Lancaster University]. We establish asymptotic weak convergence to Gaussian random variables and we give their asymptotic variance.     

Double Sampling Ratio-product Estimator of a Finite Population Mean in Sample Surveys

It is well known that two-phase (or double) sampling is of significant use in practice when the population parameter(s) (say, population mean X¯) of the auxiliary variate x is not known. Keeping this in view, we have suggested a class of ratio-product estimators in two-phase sampling with its properties. The asymptotically optimum estimators (AOEs) in the class are identified in two different cases with their variances. Conditions for the proposed estimator to be more efficient than the two-phase sampling ratio, product and mean per unit estimator are investigated. Comparison with single phase sampling is also discussed. An empirical study is carried out to demonstrate the efficiency of the suggested estimator over conventional estimators.     

Estimating the Upper Support Point in Deconvolution

Abstract.  We consider estimation of the upper boundary point F ⁻¹ (1) of a distribution function F with finite upper boundary or 'frontier' in deconvolution problems, primarily focusing on deconvolution models where the noise density is decreasing on the positive halfline. Our estimates are based on the (non-parametric) maximum likelihood estimator (MLE) of F . We show that (1) is asymptotically never too small. If the convolution kernel has bounded support the estimator (1) can generally be expected to be consistent. In this case, we establish a relation between the extreme value index of F and the rate of convergence of (1) to the upper support point for the 'boxcar' deconvolution model. If the convolution density has unbounded support, (1) can be expected to overestimate the upper support point. We define consistent estimators , for appropriately chosen vanishing sequences ( β _n ) and study these in a particular case.