Summary of the Workshop on Issues in Risk Assessment: Quantitative Methods for Developmental Toxicology

This report summarizes the proceedings of a conference on quantitative methods for assessing the risks of developmental toxicants. The conference was planned by a subcommittee of the National Research Council's Committee on Risk Assessment Methodology ⁴ in conjunction with staff from several federal agencies, including the U.S. Environmental Protection Agency, U.S. Food and Drug Administration, U.S. Consumer Products Safety Commission, and Health and Welfare Canada. Issues discussed at the workshop included computerized techniques for hazard identification, use of human and animal data for defining risks in a clinical setting, relationships between end points in developmental toxicity testing, reference dose calculations for developmental toxicology, analysis of quantitative dose-response data, mechanisms of developmental toxicity, physiologically based pharmacokinetic models, and structure-activity relationships. Although a formal consensus was not sought, many participants favored the evolution of quantitative techniques for developmental toxicology risk assessment, including the replacement of lowest observed adverse effect levels (LOAELs) and no observed adverse effect levels (NOAELs) with the benchmark dose methodology.     

Uncertain Numbers and Uncertainty in the Selection of Input Distributions—Consequences for a Probabilistic Risk Assessment of Contaminated Land

Risks from exposure to contaminated land are often assessed with the aid of mathematical models. The current probabilistic approach is a considerable improvement on previous deterministic risk assessment practices, in that it attempts to characterize uncertainty and variability. However, some inputs continue to be assigned as precise numbers, while others are characterized as precise probability distributions. Such precision is hard to justify, and we show in this article how rounding errors and distribution assumptions can affect an exposure assessment. The outcome of traditional deterministic point estimates and Monte Carlo simulations were compared to probability bounds analyses. Assigning all scalars as imprecise numbers (intervals prescribed by significant digits) added uncertainty to the deterministic point estimate of about one order of magnitude. Similarly, representing probability distributions as probability boxes added several orders of magnitude to the uncertainty of the probabilistic estimate. This indicates that the size of the uncertainty in such assessments is actually much greater than currently reported. The article suggests that full disclosure of the uncertainty may facilitate decision making in opening up a negotiation window. In the risk analysis process, it is also an ethical obligation to clarify the boundary between the scientific and social domains.     

Semiparametric linear transformation models for current status data

Current status data arise when the death of every subject in a study cannot be determined precisely, but is known only to have occurred before or after a random monitoring time. The authors discuss the analysis of such data under semiparametric linear transformation models for which they propose a general inference procedure based on estimating functions. They determine the properties of the estimates they propose for the regression parameters of the model and illustrate their technique using tumorigenicity data.     

Retirement patterns in Hong Kong: a censored regression analysis

This paper provides an overview of retirement patterns in Hong Kong on the basis of limited data. A censored regression model is used to infer the retirement age from people‘s current retirement status and their current age. This model is equivalent to a restricted probit model, and the interpretation of parameters is straightforward. The results clearly show a negative income effect on the retirement decision. The retirement age seems to be positively related to lifetime earnings but negatively related to the rate of decline of earnings with age. JEL classification: C24, J14, J26 Received May 6, 1996 / Accepted February 5, 1997     

数字素养与农户收入差距:加剧还是缓解?——基于中西部地区的微观证据

数字经济时代,数字贫困问题对农户收入差距的影响引发新的关注。基于2021年中国农村经济与农村金融数据,采用再中心化响应函数(RIF)回归方法探究数字素养对农户收入差距的影响。研究发现:(1)数字素养显著扩大了农户收入差距,并具备明显的马太效应,高数字素养能够攫取更多数字红利,而低数字素养更容易陷入“数字贫困”状态,无法发挥出数字经济的增收效应。(2)应用数字素养会显著加剧农户收入差距,而通用数字素养对农户收入差距的影响并不显著。这种情况也得以印证,现阶段数字“接入鸿沟”已经得以解决,数字“应用鸿沟”差距逐渐凸显。(3)数字素养能够缩小农户财产性收入差距,但会显著扩大工资性收入差距与非农经营性收入差距。脱贫地区受到数字素养的马太效应更强,农户收入差距明显加剧。研究结论证实了我国农村内部存在明显的数字鸿沟,同时数字贫困问题加剧了农户收入差距。新发展阶段我国数字乡村战略的推进不仅要注重农村低收入群体以及弱势群体数字素养的培育,更要加快构建农村数字经济的包容性发展路径,助力农民农村共同富裕的实现。     

哀伤辅导视角下儿童丧亲主题绘本的疗愈效用——基于对9本绘本的叙事分析

为探究儿童丧亲主题绘本的疗愈效用,以哀伤辅导理论为指导框架对《小伤疤》等9本丧亲主题绘本进行叙事分析。研究发现,丧亲主题绘本多数都构建了完整的哀伤历程,分为5个阶段：“故事开端：叙述过去映射正向情感联结;第一次转折：以委婉言语表达死亡事实;情绪高潮：主人公强烈宣泄负面情绪;第二次转折：寻求超越死亡的生命意义;故事结尾：与过去挥手告别开启新生活。”但仍存在一些不足之处可以优化。例如,绘本创作要直面亲人死亡的生物性事实,建构亲人“永生”的现实意义,结合中国本土文化进行创新。作为家长及教育工作者,要关注丧亲儿童的心理健康,灵活运用绘本对儿童进行死亡教育,帮助丧亲儿童走出哀伤。     

媒介再现父职：“新父亲”形象与父职教育契机——基于网络短视频的内容分析

随着网络短视频在日常生活中的广泛渗透,以“爸爸带娃”为主题的家庭父职生活也逐渐媒介化。以微信视频号、小红书和抖音三大主流网络平台的短视频为研究对象,采用内容分析法,探究媒介再现父职中的“新父亲”形象,以及媒介再现父职隐含的父职教育契机。研究发现：媒介再现父职以“关爱父职”为主导,关爱父职影响积极且效果良好;父亲参与意愿和参与主动性强;父亲参与的互动性较为充分;平等、亲和、睿智的父亲形象突出;引流变现下的“花式带娃”等多样化“新父亲”形象。鉴于网络传播的巨大影响力和实效性,媒介再现父职的促进路径为：推动新父职理念的传播与实践转向;设立常人榜样,实现父职教育的日常渗透;明确本土化父职研究方向,拓展父亲情感参与维度。     

基于VARK学习风格的远程社会情感学习课程研究

基于VARK学习风格模型,以对应分析方法对IY、第二步、CKCC和积极行动四门远程社会情感学习课程的研究发现：课程学习风格偏好具有差异,其教学活动体现出不同的风格搭配且混合式学习是实现不同学习风格的主要方式。其中,IY偏好视觉和动觉的学习风格,教学活动主要包括观看视频,然后根据指示进行有道具的情境模拟活动,主要以视频课作为远程教学方式;第二步偏好读写的学习风格,教学活动主要包括阅读图片文字材料,然后完成书写类的作业,主要以数字课程作为实现方式;CKCC同样偏好读写的学习风格,教学活动主要包括教材阅读,同时伴随讨论和讲述,主要以直播课为远程教学方式;积极行动偏好听觉的学习风格,更加注重同伴间的讨论和互动,同样以在线直播课程为远程教学方式。这四门课程为其它远程社会情感学习课程开发提供了借鉴,包括课程特色和教学目标与学习风格需匹配,以及混合式学习促进不同学习风格活动效果。     

信息分析与预测产业化的法律环境分析

信息分析与预测产业化从产品商品化开始,这是一个庞大的系统工程。其商品化引发了一系列产业连带效应,促进其在服务方式、服务内容、管理体制等方面迅速与市场接轨,并整体向产业化进军。依据我国国情与国际惯例,必须吸收其它部门的立法经验与成果,建立整套完善的有中国特色的信息法律体系。     

Decision Analysis and Risk Management Decision Making: Issues and Methods

This paper provides an overview of decision analysis and its use in risk management decision making. The paper discusses the distinctive characteristics of decision analysis and compares these characteristics with those of its principal alternative—cost–benefit analysis. The paper also discusses each of the steps in a decision analysis and the strengths and limitations of the method.