Confidence Bands for Comparison of Transition Probabilities in a Markov Chain Model

We consider graphs, confidence procedures and tests that can be used to compare transition probabilities in a Markov chain model with intensities specified by a Cox proportional hazard model. Under assumptions of this model, the regression coefficients provide information about the relative risks of covariates in one–step transitions, however, they cannot in general be used to to assess whether or not the covariates have a beneficial or detrimental effect on the endpoint events. To alleviate this problem, we consider graphical tests based on confidence procedures for a generalized Q–Q plot and for the difference between transition probabilities. The procedures are illustrated using data of the International Bone Marrow Transplant Registry.     

Inference and Optimal Design Based on Step—Partially Accelerated Life Tests for the Generalized Pareto Distribution under Progressive Type-I Censoring

Various types of failure, censored and accelerated life tests, are commonly employed for life testing in some manufacturing industries and products that are highly reliable. In this article, we consider the tampered failure rate model as one of such types that relate the distribution under use condition to the distribution under accelerated condition. It is assumed that the lifetimes of products under use condition have generalized Pareto distribution as a lifetime model. Some estimation methods such as graphical, moments, probability weighted moments, and maximum likelihood estimation methods for the parameters are discussed based on progressively type-I censored data. The determination of optimal stress change time is discussed under two different criteria of optimality. Finally, a Monte Carlo simulation study is carried out to examine the performance of the estimation methods and the optimality criteria.     

A Class of Weighted Estimating Equations for Semiparametric Transformation Models with Missing Covariates

In survival analysis, covariate measurements often contain missing observations; ignoring this feature can lead to invalid inference. We propose a class of weighted estimating equations for right‐censored data with missing covariates under semiparametric transformation models. Time‐specific and subject‐specific weights are accommodated in the formulation of the weighted estimating equations. We establish unified results for estimating missingness probabilities that cover both parametric and non‐parametric modelling schemes. To improve estimation efficiency, the weighted estimating equations are augmented by a new set of unbiased estimating equations. The resultant estimator has the so‐called ‘double robustness’ property and is optimal within a class of consistent estimators.     

Block censoring scheme with two-parameter exponential distribution

This paper deals with a new censoring scheme, called ‘Block Censoring’ which reduces considerably the total time on test in the life testing experiments with respect to the common used experimental tests such as rightly censored data. This new scheme is analysed when the lifetimes of products follow the two-parameter exponential distribution. Specially, it is proved that the respective spacings are independently distributed exponential. The problem of estimating parameters is investigated in details.A Monte Carlo simulation is conducted for obtaining the optimal block censoring scheme in the sense of the shortest expected test time. Finally, a real data set on times to breakdown of an insulating fluid between electrodes from Nelson [Applied life data analysis. New York: Wiley; 1982. p.105] is analysed.     

Estimation and prediction for an inverted exponentiated Rayleigh distribution under hybrid censoring

In this paper we consider estimation of unknown parameters of an inverted exponentiated Rayleigh distribution when it is known that data are hybrid Type I censored. The maximum likelihood and Bayes estimates are derived. In sequel interval estimates are also constructed. We further consider one- and two-sample prediction of future observations and also obtain prediction intervals. The performance of proposed methods of estimation and prediction is studied using simulations and an illustrative example is discussed in support of the suggested methods.     

Targeted estimation of state occupation probabilities for the non-Markov illness-death model

We use semi-parametric efficiency theory to derive a class of estimators for the state occupation probabilities of the continuous-time irreversible illness-death model. We consider both the setting with and without additional baseline information available, where we impose no specific functional form on the intensity functions of the model. We show that any estimator in the class is asymptotically linear under suitable assumptions about the estimators of the intensity functions. In particular, the assumptions are weak enough to allow the use of data-adaptive methods, which is important for making the identifying assumption of coarsening at random plausible in realistic settings. We suggest a flexible method for estimating the transition intensity functions of the illness-death model based on penalized Poisson regression. We apply this method to estimate the nuisance parameters of an illness-death model in a simulation study and a real-world application.