LIMIT THEOREMS FOR ASYMPTOTICALLY MINIMAX ESTIMATION OF A DISTRIBUTION WITH INCREASING FAILURE RATE UNDER A RANDOM MIXED CENSORSHIP/TRUNCATION MODEL

ABSTRACT

The search for optimal non-parametric estimates of the cumulative distribution and hazard functions under order constraints inspired at least two earlier classic papers in mathematical statistics: those of Kiefer and Wolfowitz[1] Kiefer, J. and Wolfowitz, J. 1976. Asymptotically Minimax Estimation of Concave and Convex Distribution Functions. Z. Wahrsch. Verw. Gebiete, 34: 73–85. [Crossref], [Web of Science ®] , [Google Scholar] and Grenander[2] Grenander, U. 1956. On the Theory of Mortality Measurement. Part II. Scand. Aktuarietidskrift J., 39: 125–153.  [Google Scholar] respectively. In both cases, either the greatest convex minorant or the least concave majorant played a fundamental role. Based on Kiefer and Wolfowitz's work, Wang3-4 Wang, J.L. 1986. Asymptotically Minimax Estimators for Distributions with Increasing Failure Rate. Ann. Statist., 14: 1113–1131. Wang, J.L. 1987. Estimators of a Distribution Function with Increasing Failure Rate Average. J. Statist. Plann. Inference, 16: 415–427.   found asymptotically minimax estimates of the distribution function F and its cumulative hazard function Λ in the class of all increasing failure rate (IFR) and all increasing failure rate average (IFRA) distributions. In this paper, we will prove limit theorems which extend Wang's asymptotic results to the mixed censorship/truncation model as well as provide some other relevant results. The methods are illustrated on the Channing House data, originally analysed by Hyde.5-6 Hyde, J. 1977. Testing Survival Under Right Censoring and Left Truncation. Biometrika, 64: 225–230. Hyde, J. 1980. “Survival Analysis with Incomplete Observations”. In Biostatistics Casebook 31–46. New York: Wiley Series in Probability and Mathematical Statistics: Applied Probability and Statistics.       

Small sample study on estimators of life distributions and of mean survival times using randomly censored data

Whereas large-sample properties of the estimators of survival distributions using censored data have been studied by many authors, exact results for small samples have been difficult to obtain. In this paper we obtain the exact expression for the ath moment (a > 0) of the Bayes estimator of survival distribution using the censored data under proportional hazard model. Using the exact expression we compute the exact mean, variance and MSE of the Bayes estimator. Also two estimators ofthe mean survival time based on the Kaplan-Meier estimator and the Bayes estimator are compared for small samples under proportional hazards.     

Marshall–Olkin Extended Lomax Distribution and Its Application to Censored Data

The problem of making statistical inference about θ =P(X > Y) has been under great investigation in the literature using simple random sampling (SRS) data. This problem arises naturally in the area of reliability for a system with strength X and stress Y. In this study, we will consider making statistical inference about θ using ranked set sampling (RSS) data. Several estimators are proposed to estimate θ using RSS. The properties of these estimators are investigated and compared with known estimators based on simple random sample (SRS) data. The proposed estimators based on RSS dominate those based on SRS. A motivated example using real data set is given to illustrate the computation of the newly suggested estimators.     

A simple,doubly robust,efficient estimator for survival functions using pseudo observations

Survival functions are often estimated by nonparametric estimators such as the Kaplan‐Meier estimator. For valid estimation, proper adjustment for confounding factors is needed when treatment assignment may depend on confounding factors. Inverse probability weighting is a commonly used approach, especially when there is a large number of potential confounders to adjust for. Direct adjustment may also be used if the relationship between the time‐to‐event and all confounders can be modeled. However, either approach requires a correctly specified model for the relationship between confounders and treatment allocation or between confounders and the time‐to‐event. We propose a pseudo‐observation–based doubly robust estimator, which is valid when either the treatment allocation model or the time‐to‐event model is correctly specified and is generally more efficient than the inverse probability weighting approach. The approach can be easily implemented using standard software. A simulation study was conducted to evaluate this approach under a number of scenarios, and the results are presented and discussed. The results confirm robustness and efficiency of the proposed approach. A real data example is also provided for illustration.     

A flexible parametric survival model for fitting time to event data in clinical trials

Time‐to‐event data are common in clinical trials to evaluate survival benefit of a new drug, biological product, or device. The commonly used parametric models including exponential, Weibull, Gompertz, log‐logistic, log‐normal, are simply not flexible enough to capture complex survival curves observed in clinical and medical research studies. On the other hand, the nonparametric Kaplan Meier (KM) method is very flexible and successful on catching the various shapes in the survival curves but lacks ability in predicting the future events such as the time for certain number of events and the number of events at certain time and predicting the risk of events (eg, death) over time beyond the span of the available data from clinical trials. It is obvious that neither the nonparametric KM method nor the current parametric distributions can fulfill the needs in fitting survival curves with the useful characteristics for predicting. In this paper, a full parametric distribution constructed as a mixture of three components of Weibull distribution is explored and recommended to fit the survival data, which is as flexible as KM for the observed data but have the nice features beyond the trial time, such as predicting future events, survival probability, and hazard function.     

Risk Analysis for Autonomous Underwater Vehicle Operations in Extreme Environments

Autonomous underwater vehicles (AUVs) are used increasingly to explore hazardous marine environments. Risk assessment for such complex systems is based on subjective judgment and expert knowledge as much as on hard statistics. Here, we describe the use of a risk management process tailored to AUV operations, the implementation of which requires the elicitation of expert judgment. We conducted a formal judgment elicitation process where eight world experts in AUV design and operation were asked to assign a probability of AUV loss given the emergence of each fault or incident from the vehicle's life history of 63 faults and incidents. After discussing methods of aggregation and analysis, we show how the aggregated risk estimates obtained from the expert judgments were used to create a risk model. To estimate AUV survival with mission distance, we adopted a statistical survival function based on the nonparametric Kaplan‐Meier estimator. We present theoretical formulations for the estimator, its variance, and confidence limits. We also present a numerical example where the approach is applied to estimate the probability that the Autosub3 AUV would survive a set of missions under Pine Island Glacier, Antarctica in January–March 2009.     

Non-parametric Estimation of a Survival Function with Two-stage Design Studies

Abstract.  The two-stage design is popular in epidemiology studies and clinical trials due to its cost effectiveness. Typically, the first stage sample contains cheaper and possibly biased information, while the second stage validation sample consists of a subset of subjects with accurate and complete information. In this paper, we study estimation of a survival function with right-censored survival data from a two-stage design. A non-parametric estimator is derived by combining data from both stages. We also study its large sample properties and derive pointwise and simultaneous confidence intervals for the survival function. The proposed estimator effectively reduces the variance and finite-sample bias of the Kaplan–Meier estimator solely based on the second stage validation sample. Finally, we apply our method to a real data set from a medical device postmarketing surveillance study.     

Statistical diagnosis for non-parametric regression models with random right censorship based on the empirical likelihood method

In this paper, we consider statistical diagnostic for non-parametric regression models with right-censored data based on empirical likelihood. First, the primary model is transformed to the non-parametric regression model. Then, based on empirical likelihood methodology, we define some diagnostic statistics. At last, some simulation studies show that our proposed procedure can work fairly well.     

Bias and Variance of the Nonparametric MLE Under Length-Biased Censored Sampling: A Simulation Study

Abstract

In some applications, the available data suffer from several sampling problems related to loss of information. This typically happens in Survival Analysis, where models for truncation, censorship, and biasing have been proposed and widely investigated. In this work, we analyze by simulations the (finite sample) bias and variance of the nonparametric MLE under length-biasing and right-censorship, recently introduced by de Uńa-Álvarez [de Uńa-Álvarez, J. (2002a). Product-limit estimation for length-biased censored data. Test 11:109–125]. Comparison with the time-honoured Kaplan–Meier estimate for censored data is included.