A partial score test for difference among heterogeneous populations

In event time data analysis, comparisons between distributions are made by the logrank test. When the data appear to contain crossing hazards phenomena, nonparametric weighted logrank statistics are usually suggested to accommodate different-weighted functions to increase the power. However, the gain in power by imposing different weights has its limits since differences before and after the crossing point may balance each other out. In contrast to the weighted logrank tests, we propose a score-type statistic based on the semiparametric-, heteroscedastic-hazards regression model of Hsieh [2001. On heteroscedastic hazards regression models: theory and application. J. Roy. Statist. Soc. Ser. B 63, 63–79.], by which the nonproportionality is explicitly modeled. Our score test is based on estimating functions derived from partial likelihood under the heteroscedastic model considered herein. Simulation results show the benefit of modeling the heteroscedasticity and power of the proposed test to two classes of weighted logrank tests (including Fleming–Harrington's test and Moreau's locally most powerful test), a Renyi-type test, and the Breslow's test for acceleration. We also demonstrate the application of this test by analyzing actual data in clinical trials.     

An empirical likelihood goodness-of-fit test for time series

Summary. Standard goodness-of-fit tests for a parametric regression model against a series of nonparametric alternatives are based on residuals arising from a fitted model. When a parametric regression model is compared with a nonparametric model, goodness-of-fit testing can be naturally approached by evaluating the likelihood of the parametric model within a nonparametric framework. We employ the empirical likelihood for an α -mixing process to formulate a test statistic that measures the goodness of fit of a parametric regression model. The technique is based on a comparison with kernel smoothing estimators. The empirical likelihood formulation of the test has two attractive features. One is its automatic consideration of the variation that is associated with the nonparametric fit due to empirical likelihood's ability to Studentize internally. The other is that the asymptotic distribution of the test statistic is free of unknown parameters, avoiding plug-in estimation. We apply the test to a discretized diffusion model which has recently been considered in financial market analysis.     

A circular-cone test for testing homogeneity against a simple tree order

Several methods exist for the problem of testing the equality of several treatments against the one-sided alternative that the treatments are better than the control. These methods include Dunnett's test, Bartholomew's likelihood-ratio test, the Abelson-Tukey-Schaafsma-Smid optimal-contrast test, and the multiple-contrast test of Mukerjee, Robertson, and Wright. A new test is proposed based on an approximation of the likelihood-ratio test of Bartholomew. This test involves using a circular cone in place of the alternative-hypothesis cone. The circular-cone test has excellent power characteristics similar to those of Bartholomew's test. Moreover, it has the advantages of being simpler to compute and may be used with unequal sample sizes.     

Summary of the Workshop on Issues in Risk Assessment: Quantitative Methods for Developmental Toxicology

This report summarizes the proceedings of a conference on quantitative methods for assessing the risks of developmental toxicants. The conference was planned by a subcommittee of the National Research Council's Committee on Risk Assessment Methodology ⁴ in conjunction with staff from several federal agencies, including the U.S. Environmental Protection Agency, U.S. Food and Drug Administration, U.S. Consumer Products Safety Commission, and Health and Welfare Canada. Issues discussed at the workshop included computerized techniques for hazard identification, use of human and animal data for defining risks in a clinical setting, relationships between end points in developmental toxicity testing, reference dose calculations for developmental toxicology, analysis of quantitative dose-response data, mechanisms of developmental toxicity, physiologically based pharmacokinetic models, and structure-activity relationships. Although a formal consensus was not sought, many participants favored the evolution of quantitative techniques for developmental toxicology risk assessment, including the replacement of lowest observed adverse effect levels (LOAELs) and no observed adverse effect levels (NOAELs) with the benchmark dose methodology.     

阅读测验中认知与元认知策略研究

语言知识、策略能力和情绪等心理和社会特征在语言使用中交互作用,并对语言沟通能力产生影响。文章采用定量与定性方法对其预测性及内部关联加以实证。研究发现二者关联度很强,元认知策略对绩效预测力显著强于认知策略。认知与元认知策略呈现相互嵌套模式,相同加工行动在不同情境中由于履行功能差异而转换角色。     

全球化语境中的对话文化学的建立

文化是永远朝向自我认同而存在的人的现实生活。由全球化凸现出来的文化冲突反映了人面对异质性存在而产生的自我认同危机。中国传统文化与西方文化的差异不仅表现在内容上,而且表现在它们在当今人类文化格局中所处地位的不同上,即西方文化处于权力话语地位,而中国传统文化却岌岌可危。文化对话不仅是人类共建一种异中求“和”的世界文化新格局的正确途径,而且是中国文化健康发展的正确途径。在当代,建立对话的文化学已刻不容缓。建立对话的文化学不仅是一种普遍的对话范式在文化理论中的确立,而且要求我们在文化实践和社会实践中展开对权力话语的批判。     

科学执政、民主执政中的依法执政基本途径

依法执政或依法行政,作为执政方式最为直接、最为具体的基本实践环节或途径,在相当范围内反映着科学执政、民主执政的实现程度。这取决于《行政许可法》不打折扣地坚决实施,政府的依法执政职能方式从重管制向重服务转变;职能范围从“全能”向“有限”回归;职能性质由“专断”走向真正“民主”;职能习惯从主观随意转向严格的法治。     

On the preservation of copula structure under truncation

The author characterizes the copula associated with the bivariate survival model of Clayton (1978) as the only absolutely continuous copula that is preserved under bivariate truncation.     

关系化用工:农业规模经营的社会基础

农业规模经营是中国乡村振兴进程中的关键议题。农业规模经营在快速发展的同时也呈现出用工效益的差异,从而使一些规模农业经营主体陷入困境。采用嵌入性视角探讨农业规模经营中用工模式嵌入社会关系的逻辑及其影响。研究发现,农业规模经营陷入困境的主要原因在于市场化用工无法有效解决农业规模经营中的劳动监督问题。而将市场规则嵌入关系规则的关系化用工使得雇佣双方产生了利他倾向,进而在很大程度上调动了工人内在的劳动积极性,从而使农业规模经营主体摆脱经营失败困境。关系化用工的实现依赖于农业规模经营主体在用工选择、生产管理和日常生活中充分发挥社会关系的积极作用,但社会关系范围和程度都是有限度的。因此,农业规模经营的健康发展不仅需要处理好经济关系,而且需要处理好社会关系。     

泰乐松注射液的毒理学试验研究

为提供泰乐松注射液的安全性毒理学评价资料,本试验采用改进Karber法测定小鼠LD_(50);以剂量递增法测定小鼠蓄积性和耐受性;分别以剂量340、130、30mg／kg为3个试验组．设阴性和阳性对照组进行小鼠骨髓微核试验;分别以剂量500、250、120mg／kg为3个剂量组．设阴性和阳性对照组进行小鼠精于畸形试验。结果表明：其LD_(50)为669．80mg／kg,蓄积系数大于5．3,无明显蓄积毒性和耐受性（P＞0．05）,小鼠骨髓微核试验和精子畸形试验结果均为阴性。