Notes on Interval Estimation of Odds Ratio in Matched Pairs under Stratified Sampling

We develop four asymptotic interval estimators and one exact interval estimator for the odds ratio (OR) under stratified random sampling with matched pairs. We apply Monte Carlo simulation to evaluate the performance of these five interval estimators. We note that the conditional score test-based interval estimator with a monotonic transformation and the interval estimator based on the Mantel–Haenszel (MH) type point estimator with the logarithmic transformation are generally preferable to the others considered here. We also note that the conditional exact confidence interval can be of use when the total number of matched pairs with discordant responses is small.     

Limit theorems for dependent Bernoulli variables with statistical inference

We consider a class of dependent Bernoulli variables where the conditional success probability is a linear combination of the last few trials and the original success probability. We obtain its limit theorems including the strong law of large numbers, weak invariance principle, and law of the iterated logarithm. We also derive some statistical inference results which make the model applicable. Simulation results are exhibited as well to show that with small sample size the convergence rate is satisfying and the proposed estimators behave well.     

Population structure and correlation between auxiliary and target variables may affect precision of estimates in forest inventory

Simulations of forest inventory in several populations compared simple random with “quick probability proportional to size” (QPPS) sampling. The latter may be applied in the absence of a list sampling frame and/or prior measurement of the auxiliary variable. The correlation between the auxiliary and target variables required to render QPPS sampling more efficient than simple random sampling varied over the range 0.3–0.6 and was lower when sampling from populations that were skewed to the right. Two possible analytical estimators of the standard error of the estimate of the mean for QPPS sampling were found to be less reliable than bootstrapping.     

Marginal likelihood estimation from the Metropolis output: tips and tricks for efficient implementation in generalized linear latent variable models

The marginal likelihood can be notoriously difficult to compute, and particularly so in high-dimensional problems. Chib and Jeliazkov employed the local reversibility of the Metropolis–Hastings algorithm to construct an estimator in models where full conditional densities are not available analytically. The estimator is free of distributional assumptions and is directly linked to the simulation algorithm. However, it generally requires a sequence of reduced Markov chain Monte Carlo runs which makes the method computationally demanding especially in cases when the parameter space is large. In this article, we study the implementation of this estimator on latent variable models which embed independence of the responses to the observables given the latent variables (conditional or local independence). This property is employed in the construction of a multi-block Metropolis-within-Gibbs algorithm that allows to compute the estimator in a single run, regardless of the dimensionality of the parameter space. The counterpart one-block algorithm is also considered here, by pointing out the difference between the two approaches. The paper closes with the illustration of the estimator in simulated and real-life data sets.     

Bayes shrinkage estimator for consistency assessment of treatment effects in multi-regional clinical trials

The primary objective of a multi-regional clinical trial is to investigate the overall efficacy of the drug across regions and evaluate the possibility of applying the overall trial result to some specific region. A challenge arises when there is not enough regional sample size. We focus on the problem of evaluating applicability of a drug to a specific region of interest under the criterion of preserving a certain proportion of the overall treatment effect in the region. We propose a variant of James-Stein shrinkage estimator in the empirical Bayes context for the region-specific treatment effect. The estimator has the features of accommodating the between-region variation and finiteness correction of bias. We also propose a truncated version of the proposed shrinkage estimator to further protect risk in the presence of extreme value of regional treatment effect. Based on the proposed estimator, we provide the consistency assessment criterion and sample size calculation for the region of interest. Simulations are conducted to demonstrate the performance of the proposed estimators in comparison with some existing methods. A hypothetical example is presented to illustrate the application of the proposed method.     

Infill asymptotics for adaptive kernel estimators of spatial intensity

We apply the Abramson principle to define adaptive kernel estimators for the intensity function of a spatial point process. We derive asymptotic expansions for the bias and variance under the regime that n independent copies of a simple point process in Euclidean space are superposed. The method is illustrated by means of a simple example and applied to tornado data.     

Smooth tail-index estimation

The two parametric distribution functions appearing in the extreme-value theory – the generalized extreme-value distribution and the generalized Pareto distribution – have log-concave densities if the extreme-value index γ∈[?1, 0]. Replacing the order statistics in tail-index estimators by their corresponding quantiles from the distribution function that is based on the estimated log-concave density ? f _n leads to novel smooth quantile and tail-index estimators. These new estimators aim at estimating the tail index especially in small samples. Acting as a smoother of the empirical distribution function, the log-concave distribution function estimator reduces estimation variability to a much greater extent than it introduces bias. As a consequence, Monte Carlo simulations demonstrate that the smoothed version of the estimators are well superior to their non-smoothed counterparts, in terms of mean-squared error.     

Rank invariant tests with left truncated and interval censored data

Peto and Peto (1972) have studied rank invariant tests to compare two survival curves for right censored data. We apply their tests, including the logrank test and the generalized Wilcoxon test, to left truncated and interval censored data. The significance levels of the tests are approximated by Monte Carlo permutation tests. Simulation studies are conducted to show their size and power under different distributional differences. In particular, the logrank test works well under the Cox proportional hazards alternatives, as for the usual right censored data. The methods are illustrated by the analysis of the Massachusetts Health Care Panel Study dataset.     

Estimating the variance of the sample median

The small-sample bias and root mean squared error of several distribution-free estimators of the variance of the sample median are examined. A new estimator is proposed that is easy to compute and tends to have the smallest bias and root mean squared error.     

On Pitman's measure of closeness of k-records

Pitman closeness of both the upper and lower k-record statistics to the population quantiles of a location–scale family of distributions is studied. For the population median, the Pitman-closest k-record is also determined. In the case of symmetric distributions, the Pitman closeness probabilities of k-record statistics are shown to be distribution-free, and explicit expressions are also derived for these probabilities. Exact expressions are derived for the required probabilities for uniform and exponential distributions. Numerical results are given for these families and also the Pitman-closest k-record is determined.