Regression models for analyzing clustered binary and continuous outcomes under an assumption of exchangeability

Scientific experiments commonly result in clustered discrete and continuous data. Existing methods for analyzing such data include the use of quasi-likelihood procedures and generalized estimating equations to estimate marginal mean response parameters. In applications to areas such as developmental toxicity studies, where discrete and continuous measurements are recorded on each fetus, or clinical ophthalmologic trials, where different types of observations are made on each eye, the assumption that data within cluster are exchangeable is often very reasonable. We use this assumption to formulate fully parametric regression models for clusters of bivariate data with binary and continuous components. The regression models proposed have marginal interpretations and reproducible model structures. Tractable expressions for likelihood equations are derived and iterative schemes are given for computing efficient estimates (MLEs) of the marginal mean, correlations, variances and higher moments. We demonstrate the use the ‘exchangeable’ procedure with an application to a developmental toxicity study involving fetal weight and malformation data.     

李土司家族的婚姻关系及其社会影响

李土司家族是河湟地区最著名的土司家族之一,婚姻在其家族的发展中曾发挥十分重要的作用。本文旨在分析和阐释其婚姻关系及其所产生的社会影响。     

Empirical likelihood for the difference of quantiles under censorship

In this paper, we use a smoothed empirical likelihood method to investigate the difference of quantiles under censorship. An empirical log-likelihood ratio is derived and its asymptotic distribution is shown to be chi-squared. Approximate confidence regions based on this method are constructed. Simulation studies are used to compare the empirical likelihood and the normal approximation method in terms of its coverage accuracy. It is found that the empirical likelihood method provides a much better performance. The research is supported by NSFC (10231030) and RFDP.     

Confidence intervals on intraclass correlation coefficients in a balanced two-factor random design

A modified large-sample (MLS) approach and a generalized confidence interval (GCI) approach are proposed for constructing confidence intervals for intraclass correlation coefficients. Two particular intraclass correlation coefficients are considered in a reliability study. Both subjects and raters are assumed to be random effects in a balanced two-factor design, which includes subject-by-rater interaction. Computer simulation is used to compare the coverage probabilities of the proposed MLS approach (GiTTCH) and GCI approaches with the Leiva and Graybill [1986. Confidence intervals for variance components in the balanced two-way model with interaction. Comm. Statist. Simulation Comput. 15, 301–322] method. The competing approaches are illustrated with data from a gauge repeatability and reproducibility study. The GiTTCH method maintains at least the stated confidence level for interrater reliability. For intrarater reliability, the coverage is accurate in several circumstances but can be liberal in some circumstances. The GCI approach provides reasonable coverage for lower confidence bounds on interrater reliability, but its corresponding upper bounds are too liberal. Regarding intrarater reliability, the GCI approach is not recommended because the lower bound coverage is liberal. Comparing the overall performance of the three methods across a wide array of scenarios, the proposed modified large-sample approach (GiTTCH) provides the most accurate coverage for both interrater and intrarater reliability.     

Some properties of a linear combination CUSUM statistic for controlling a multivariate mean vector

We develop a class of new multivariate procedures for monitoring quality by detecting a change in the level of a multivariate process. Following the ideas of S.N. Roy, we first consider a linear combination statistic which results from projecting the multivariate observations onto a unit vector and then maximizing a selected univariate statistic over all directions.     

Designs for cropping systems research

The present article establishes equivalence between extended group divisible (EGD) designs and designs for crop sequence experiments. This equivalence has encouraged the agricultural experimenters to use EGD designs for their experimentation. Some real life applications of EGD designs have been given. It has also been shown that several existing association schemes are special cases of EGD association scheme. Some methods of construction of EGD designs are also given. A catalogue of EGD designs obtainable through methods of construction along with efficiency factors of various factorial effects is also presented. In some crop sequence experiments that are conducted to develop suitable integrated nutrient supply system of a crop sequence, the treatments do not comprise of a complete factorial structure. The experimenter is interested in estimating the residual and direct effect of the treatments along with their cumulative effects. For such experimental settings block designs with two sets of treatments applied in succession are the appropriate designs. The correspondence established between row–column designs and block designs for two stage experiments by Parsad et al. [2003. Structurally incomplete row–column designs. Comm. Statist. Theory Methods 32(1), 239–261] has been exploited in obtaining designs for such experimental situations. Some open problems related to designing of crop sequence experiments are also given.     

Asymptotic distributions of statistics and parameter estimates for mixed Poisson processes

Mixed Poisson processes have been used as natural models for events occurring in continuous or discrete time. Our main result is the derivation of the joint asymptotic distributions of statistics, including parameter estimators, computed in different time intervals from data generated by mixed Poisson processes. These distributions can be used, for example, to test the hypothesis about the adequacy of the mixed Poisson process against data. We provide some simulation results and test the model on actual market research data.     

湘语“V+X+N（L）”的结构形式及来源

湖南境内湘语“V+X+N（L）”的结构形式共有四种：“V+在+N（L）”、“V+到+N（L）”，“V+体貌助词+N（L）”和“V+体貌助词+在+N（L）”。“V+体貌助词+在+N（L）”的来源于六朝时期就已常见的“（S-P）在NL”结构。     

On representing maximin efficient designs by Taylor series

This paper considers exponential and rational regression models that are nonlinear in some parameters. Recently, locally D-optimal designs for such models were investigated in [Melas, V. B., 2005. On the functional approach to optimal designs for nonlinear models. J. Statist. Plann. Inference 132, 93–116] based upon a functional approach. In this article a similar method is applied to construct maximin efficient D-optimal designs. This approach allows one to represent the support points of the designs by Taylor series, which gives us the opportunity to construct the designs by hand using tables of the coefficients of the series. Such tables are provided here for models with two nonlinear parameters. Furthermore, the recurrent formulas for constructing the tables for arbitrary numbers of parameters are introduced.     

Optimal crossover designs when carryover effects are proportional to direct effects

Crossover designs are used for a variety of different applications. While these designs have a number of attractive features, they also induce a number of special problems and concerns. One of these is the possible presence of carryover effects. Even with the use of washout periods, which are for many applications widely accepted as an indispensable component, the effect of a treatment from a previous period may not be completely eliminated. A model that has recently received renewed attention in the literature is the model in which first-order carryover effects are assumed to be proportional to direct treatment effects. Under this model, assuming that the constant of proportionality is known, we identify optimal and efficient designs for the direct effects for different values of the constant of proportionality. We also consider the implication of these results for the case that the constant of proportionality is not known.