Estimated Generalized Estimating Equation for Correlated Failure Time Data with Auxiliary Covariates

In this article, we study a marginal hazard model with common baseline hazard for correlated failure time data. We assume that the true covariate is measured precisely in a subset of the whole study cohort, whereas an auxiliary information for the true covariate is available for the whole cohort. We first estimate the relative risk function empirically. Then we obtain the estimator for the regression parameter by replacing the relative risk function with its estimator in a generalized estimating equation (GEE) proposed by Cai (1992 Cai , J. ( 1992 ). Generalized estimation equations for censored multivariate failure time data. Ph.D. thesis, University of Washington, Seattle, Washington . [Google Scholar]). A key feature of this method is that it is nonparametric with respect to the association between the missing covariate and the observed auxiliary covariate. The proposed estimator is shown to be consistent and asymptotically normal. Furthermore, we present a corrected Breslow-type estimator for the cumulative hazard function. Simulation studies are conducted to evaluate the proposed method.     

EWMA Control Charts for Monitoring High Yield Processes

The main objective of this article is to scrutinize the efficiency and verify the performance superiority of the one-sided EWMA control chart on high-yield processes. The proposed control chart is designed to detect both upward and downward shifts of the fraction of non conforming products and is developed based on non transformed geometric counts. Its algorithmic function is theoretically established and numerous performance measures are extracted using analytical methods based on the Markov modeling of the chart. Comparisons with traditional high yield control charts are conducted. Optimality tables and nomograms are included to help graphical determination of the optimal chart parameters.     

A unified approach to marginal equivalence in the general framework of group invariance

ABSTRACT

Two Bayesian models with different sampling densities are said to be marginally equivalent if the joint distribution of observables and the parameter of interest is the same for both models. We discuss marginal equivalence in the general framework of group invariance. We introduce a class of sampling models and derive marginal equivalence when the prior for the nuisance parameter is relatively invariant. We also obtain some robustness properties of invariant statistics under our sampling models. Besides the prototypical example of v-spherical distributions, we apply our general results to two examples—analysis of affine shapes and principal component analysis.     

The Performance of Two Data-Generation Processes for Data with Specified Marginal Treatment Odds Ratios

Monte Carlo simulation methods are increasingly being used to evaluate the property of statistical estimators in a variety of settings. The utility of these methods depends upon the existence of an appropriate data-generating process. Observational studies are increasingly being used to estimate the effects of exposures and interventions on outcomes. Conventional regression models allow for the estimation of conditional or adjusted estimates of treatment effects. There is an increasing interest in statistical methods for estimating marginal or average treatment effects. However, in many settings, conditional treatment effects can differ from marginal treatment effects. Therefore, existing data-generating processes for conditional treatment effects are of little use in assessing the performance of methods for estimating marginal treatment effects. In the current study, we describe and evaluate the performance of two different data-generation processes for generating data with a specified marginal odds ratio. The first process is based upon computing Taylor Series expansions of the probabilities of success for treated and untreated subjects. The expansions are then integrated over the distribution of the random variables to determine the marginal probabilities of success for treated and untreated subjects. The second process is based upon an iterative process of evaluating marginal odds ratios using Monte Carlo integration. The second method was found to be computationally simpler and to have superior performance compared to the first method.     

企业安全投资效益的影响因素分析

通过对企业安全程度水平变化的边际效益和边际成本进行比较,寻找企业安全投资最优的安全投入。提出合理地有效的安全投资是提高企业安全生产水平和创造经济效益的重要手段。在此基础上分析了企业对安全投资的认识水平、企业员工的安全意识及安全行为的规范和政府规制等具体因素对企业安全投资效益的影响。     

中国省际资本边际报酬估算

 资本边际报酬是决定投资和资本配置的重要因素。本文利用中国省际宏观数据,估算了1990-2006年中国各省的资本边际报酬。结果显示,我国各省、直辖市的资本边际报酬呈现出东部沿海地区较高,而中西部地区较低的状况。同时,部分较落后地区的资本边际报酬不断增加,甚至已经超过了大部分沿海省份,而沿海省份的资本边际报酬增长趋势不再明显,很多省份呈现持平甚至下降趋势。这一结果说明,我国固定资本投资极不平衡的现象与中国省际的资本边际报酬估算结果是一致的,但是根据资本边际报酬的变化趋势,该问题在今后或许可以得到缓解。     

Likelihood‐based and marginal inference methods for recurrent event data with covariate measurement error

Recurrent event data arise commonly in medical and public health studies. The analysis of such data has received extensive research attention and various methods have been developed in the literature. Depending on the focus of scientific interest, the methods may be broadly classified as intensity‐based counting process methods, mean function‐based estimating equation methods, and the analysis of times to events or times between events. These methods and models cover a wide variety of practical applications. However, there is a critical assumption underlying those methods–variables need to be correctly measured. Unfortunately, this assumption is frequently violated in practice. It is quite common that some covariates are subject to measurement error. It is well known that covariate measurement error can substantially distort inference results if it is not properly taken into account. In the literature, there has been extensive research concerning measurement error problems in various settings. However, with recurrent events, there is little discussion on this topic. It is the objective of this paper to address this important issue. In this paper, we develop inferential methods which account for measurement error in covariates for models with multiplicative intensity functions or rate functions. Both likelihood‐based inference and robust inference based on estimating equations are discussed. The Canadian Journal of Statistics 40: 530–549; 2012 © 2012 Statistical Society of Canada     

A comparison of population average and random-effect models for the analysis of longitudinal count data with base-line information

The generalized estimating equation (GEE) approach to the analysis of longitudinal data has many attractive robustness properties and can provide a 'population average' characterization of interest, for example, to clinicians who have to treat patients on the basis of their observed characteristics. However, these methods have limitations which restrict their usefulness in both the social and the medical sciences. This conclusion is based on the premise that the main motivations for longitudinal analysis are insight into microlevel dynamics and improved control for omitted or unmeasured variables. We claim that to address these issues a properly formulated random-effects model is required. In addition to a theoretical assessment of some of the issues, we illustrate this by reanalysing data on polyp counts. In this example, the covariates include a base-line outcome, and the effectiveness of the treatment seems to vary by base-line. We compare the random-effects approach with the GEE approach and conclude that the GEE approach is inappropriate for assessing the treatment effects for these data.     

Parameter change test for zero-inflated generalized Poisson autoregressive models

In this paper, we consider the problem of testing for parameter change in zero-inflated generalized Poisson (ZIGP) autoregressive models. We verify that the ZIGP process is stationary and ergodic and that the conditional maximum likelihood estimator (CMLE) is strongly consistent and asymptotically normal. Based on these results, we construct CMLE- and residual-based cumulative sum tests and show that their limiting null distributions are a function of independent Brownian bridges. The simulation results are provided for illustration. A real data analysis is performed on some crime data of Australia.     

A mixed poisson–inverse-gaussian regression model

The mixed Poisson–inverse-Gaussian distribution has been used by Holla, Sankaran, Sichel, and others in univariate problems involving counts. We propose a Poisson–inverse-Gaussian regression model which can be used for regression analysis of counts. The model provides an attractive framework for incorporating random effects in Poisson regression models and in handling extra-Poisson variation. Maximum-likelihood and quasilikelihood-moment estimation is investigated and illustrated with an example involving motor-insurance claims.