Repeated measurements designs - a review

Any experiment in which one or more of the experimental units is used more than once is called a repeated measurements experiment. The associated design of a repeated measurements experiment is referred to as a repeated measurements design. This review covers some known results on repeated measurements designs. Emphasis is placed on the impact of optimal design theory. Some construction methods for these designs are presented. Hedayat and Afsarinejad (1975) has an extensive bibliography of earlier literature. A bibliography of these designs published after 1974 is provided at the end of this paper.     

New class of location-parameter discrete probability distributions and their characterizations

A new class of location-parameter discrete probability distributions (LDPD) has been defined where the population mean is the location parameter. It has been shown that some single parameter discrete distributions do not belong to this class and all discrete probability distributions belonging to this class can be characterized by their variances only. Expressions are given for the first four central moments and a recurrence formula for higher central moments has been obtained. Eight theorems are given to characterize the various distributions in the LDPD class.     

Bayes estimators of the average failure rates

In the present paper we have proposed a Bayesian approach for making inferences from accelerated life tests which do not require distributional assumptions     

Comparison of estimators of the location parameter using pitman's closeness criterion

Necessary and sufficient conditions for a linear estimator to dominate another linear estimator of a location parameter under the Pitman's criterion of comparison are discussed. Consequently it is demonstrated that a linear biased estimator can not dominate a linear unbiased estimator under Pitman's criterion and that the sample mean is the Closest Linear Unbiased Estimator (CLUE). It is also shown that the ridge regression estimator with a known biasing constant can not dominate the ordinary least squares estimator. If an estimator δdominates an estimator δin the average loss sense then sufficient conditions are obtained under which δis also preferred over δunder Pitman's criterion. Further we obtain sufficient conditions under which preference under the Pitman's criterion will lead to preference under the mean squared error sense.     

Characterizations of the poisson process using,the variance

Let γ(t) be the residual life at time t of the renewal process {A(t), t > 0}, which has F as the common distribution function of the inter-arrival times. In this article we prove that if Var(γ(t)) is constant, then F will be exponentially or geometrically distributed under the assumption F is continuous or discrete respectively. An application and a related example also are given.     

A class of distributions with the linear mean residual quantile function and it’s generalizations

In the present paper, we introduce and study a class of distributions that has the linear mean residual quantile function. Various distributional properties and reliability characteristics of the class are studied. Some characterizations of the class of distributions are presented. We then present generalizations of this class of distributions using the relationship between various quantile based reliability measures. The method of L-moments is employed to estimate parameters of the class of distributions. Finally, we apply the proposed class of distributions to a real data set.     

Some results on generalized ageing classes

In this paper we provide new results about generalized ageing classes on the excess lifetime of a renewal process. We also obtain some characterizations of generalized ageing classes by means of the residual life at random time.     

On cumulative entropies

In analogy with the cumulative residual entropy recently proposed by Wang et al. [2003a. A new and robust information theoretic measure and its application to image alignment. In: Information Processing in Medical Imaging. Lecture Notes in Computer Science, vol. 2732, Springer, Heidelberg, pp. 388–400; 2003b. Cumulative residual entropy, a new measure of information and its application to image alignment. In: Proceedings on the Ninth IEEE International Conference on Computer Vision (ICCV’03), vol. 1, IEEE Computer Society Press, Silver Spring, MD, pp. 548–553], we introduce and study the cumulative entropy, which is a new measure of information alternative to the classical differential entropy. We show that the cumulative entropy of a random lifetime X can be expressed as the expectation of its mean inactivity time evaluated at X. Hence, our measure is particularly suitable to describe the information in problems related to ageing properties of reliability theory based on the past and on the inactivity times. Our results include various bounds to the cumulative entropy, its connection to the proportional reversed hazards model, and the study of its dynamic version that is shown to be increasing if the mean inactivity time is increasing. The empirical cumulative entropy is finally proposed to estimate the new information measure.     

Missing item imputation for quality-of-life instruments with application to asthma quality-of-life questionnaires

There has been increasing use of quality-of-life (QoL) instruments in drug development. Missing item values often occur in QoL data. A common approach to solve this problem is to impute the missing values before scoring. Several imputation procedures, such as imputing with the most correlated item and imputing with a row/column model or an item response model, have been proposed. We examine these procedures using data from two clinical trials, in which the original asthma quality-of-life questionnaire (AQLQ) and the miniAQLQ were used. We propose two modifications to existing procedures: truncating the imputed values to eliminate outliers and using the proportional odds model as the item response model for imputation. We also propose a novel imputation method based on a semi-parametric beta regression so that the imputed value is always in the correct range and illustrate how this approach can easily be implemented in commonly used statistical software. To compare these approaches, we deleted 5% of item values in the data according to three different missingness mechanisms, imputed them using these approaches and compared the imputed values with the true values. Our comparison showed that the row/column-model-based imputation with truncation generally performed better, whereas our new approach had better performance under a number scenarios.     

A new estimation method for Weibull-type tails based on the mean excess function

Studying the right tail of a distribution, one can classify the distributions into three classes based on the extreme value index γ$\gamma$. The class γ>0$\gamma >0$ corresponds to Pareto-type or heavy tailed distributions, while γ<0$\gamma <0$ indicates that the underlying distribution has a finite endpoint. The Weibull-type distributions form an important subgroup within the Gumbel class with γ=0$\gamma =0$. The tail behaviour can then be specified using the Weibull tail index. Classical estimators of this index show severe bias. In this paper we present a new estimation approach based on the mean excess function, which exhibits improved bias and mean squared error. The asserted properties are supported by simulation experiments and asymptotic results. Illustrations with real life data sets are provided.