高校党建与课程思政建设有效融合探究

党的建设和课程思政建设都是高校思想政治工作体系建设的重要组成部分。党建与课程思政有效融合的逻辑起点在于目标上高度一致、内容上相互交织、效果上相得益彰。现实困境主要表现在顶层设计的系统性不足、党建工作的效用发挥不够、工作队伍的能力素质不强等方面。促进党建与课程思政建设有效融合，要坚持把习近平新时代中国特色社会主义思想作为根本遵循，积极构建多方协同发力的体制机制，科学编制课程思政建设规划和行动指南，努力打造高素质的干部和教师队伍。     

A comparative study of adaptive trial designs for dose optimization

Recently, the US Food and Drug Administration Oncology Center of Excellence initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. The agency pointed out that the current paradigm for dose selection—based on the maximum tolerated dose (MTD)—is not sufficient for molecularly targeted therapies and immunotherapies, for which efficacy may not increase after the dose reaches a certain level. In these cases, it is more appropriate to identify the optimal biological dose (OBD) that optimizes the risk–benefit tradeoff of the drug. Project Optimus has spurred tremendous interest and urgent need for guidance on designing dose optimization trials. In this article, we review several representative dose optimization designs, including model-based and model-assisted designs, and compare their operating characteristics based on 10,000 randomly generated scenarios with various dose-toxicity and dose-efficacy curves and some fixed representative scenarios. The results show that, compared with model-based designs, model-assisted methods have advantages of easy-to-implement, robustness, and high accuracy to identify OBD. Some guidance is provided to help biostatisticians and clinicians to choose appropriate dose optimization methods in practice.     

我国网络意识形态安全长效机制的构建

20世纪90年代以来，随着网络信息技术的迅猛发展，以美国为首的西方国家凭借其网络霸权地位，加紧对广大发展中国家尤其是社会主义中国进行意识形态的渗透，使我国意识形态安全面临严峻挑战。因此，在分析维护我国网络意识形态安全长效机制的基本要素及其相互关系的基础上，从领导监管、预警反馈、信息疏滤、内容“保鲜”等层面构建维护我国网络意识形态安全机制的框架体系，并分析机制运行的条件、策略和保障，有利于用社会主义意识形态占领网络思想文化阵地，抵制西方国家意识形态的网络渗透，维护我国意识形态安全。     

旅游型村庄的制度赋能、社会资本和自治有效——以陕西省袁家村为例

随着乡村振兴战略的全面推进和乡村旅游的不断发展,旅游型村庄越来越多,但其如何才能自治有效尚未得到充分讨论。构建了制度赋能 社会资本激活 自治有效的递进式分析框架,并以陕西省袁家村为例对所构建的框架进行验证。研究发现,旅游型村庄自治有效的实现离不开制度对社会资本的激活,被激活的社会资本能提高村民自治主体的积极性、自治过程的效率以及自治结果的效能:党建引领、协商决策和监督保障的政治制度能加强村庄内部主体间的信任;有序竞争、科学分配和共享互助的市场体系能打造村庄利益共同体,从而赋能规范;强化个体培训、培育社会组织和实施村规民约的社会治理机制极大地推动了村庄人际网络的建设。     

计算机产业贸易保护测度及"入世"后的政策选择

我国计算机产业过去主要依靠关税保护和实施"进口替代" 战略而得以发展,经过初步计算,目前关税有效保护率仍高达13.89%。由于我国计算机产业尚处于产业成长初期,"入世"后,应加强对非关税贸易壁垒和技术引进效率的研究,以促进我国民族计算机产业在竞争激烈的国际市场上健康、迅速地发展壮大。,The development of Chinese computer indust ry was benefit from trade protection and "import substitution" strategy in the past. In the paper, several methods to measure the trade protection degree are provided. And the present effective protection degree of computer industury is c alculated to be 13.89%. The result shows that it is necessary to take some prote cting measures to accelerate computer industry growing in the international mark et.